BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

741 related articles for article (PubMed ID: 15987702)

  • 1. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
    Pollard PJ; Brière JJ; Alam NA; Barwell J; Barclay E; Wortham NC; Hunt T; Mitchell M; Olpin S; Moat SJ; Hargreaves IP; Heales SJ; Chung YL; Griffiths JR; Dalgleish A; McGrath JA; Gleeson MJ; Hodgson SV; Poulsom R; Rustin P; Tomlinson IP
    Hum Mol Genet; 2005 Aug; 14(15):2231-9. PubMed ID: 15987702
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
    Lehtonen HJ; Mäkinen MJ; Kiuru M; Laiho P; Herva R; van Minderhout I; Hogendoorn PC; Cornelisse C; Devilee P; Launonen V; Aaltonen LA
    Int J Cancer; 2007 Sep; 121(6):1386-9. PubMed ID: 17520677
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome.
    Pollard P; Wortham N; Barclay E; Alam A; Elia G; Manek S; Poulsom R; Tomlinson I
    J Pathol; 2005 Jan; 205(1):41-9. PubMed ID: 15586379
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.
    King A; Selak MA; Gottlieb E
    Oncogene; 2006 Aug; 25(34):4675-82. PubMed ID: 16892081
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.
    Ylisaukko-oja SK; Cybulski C; Lehtonen R; Kiuru M; Matyjasik J; Szymañska A; Szymañska-Pasternak J; Dyrskjot L; Butzow R; Orntoft TF; Launonen V; Lubiñski J; Aaltonen LA
    Eur J Hum Genet; 2006 Jul; 14(7):880-3. PubMed ID: 16639410
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.
    Pollard PJ; Wortham NC; Tomlinson IP
    Ann Med; 2003; 35(8):632-9. PubMed ID: 14708972
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.
    Hoekstra AS; de Graaff MA; Briaire-de Bruijn IH; Ras C; Seifar RM; van Minderhout I; Cornelisse CJ; Hogendoorn PC; Breuning MH; Suijker J; Korpershoek E; Kunst HP; Frizzell N; Devilee P; Bayley JP; Bovée JV
    Oncotarget; 2015 Nov; 6(36):38777-88. PubMed ID: 26472283
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.
    Pollard PJ; Spencer-Dene B; Shukla D; Howarth K; Nye E; El-Bahrawy M; Deheragoda M; Joannou M; McDonald S; Martin A; Igarashi P; Varsani-Brown S; Rosewell I; Poulsom R; Maxwell P; Stamp GW; Tomlinson IP
    Cancer Cell; 2007 Apr; 11(4):311-9. PubMed ID: 17418408
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Clinical and molecular progress in hereditary paraganglioma.
    Baysal BE
    J Med Genet; 2008 Nov; 45(11):689-94. PubMed ID: 18978332
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.
    Tomlinson IP; Alam NA; Rowan AJ; Barclay E; Jaeger EE; Kelsell D; Leigh I; Gorman P; Lamlum H; Rahman S; Roylance RR; Olpin S; Bevan S; Barker K; Hearle N; Houlston RS; Kiuru M; Lehtonen R; Karhu A; Vilkki S; Laiho P; Eklund C; Vierimaa O; Aittomäki K; Hietala M; Sistonen P; Paetau A; Salovaara R; Herva R; Launonen V; Aaltonen LA;
    Nat Genet; 2002 Apr; 30(4):406-10. PubMed ID: 11865300
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
    Bayley JP; van Minderhout I; Weiss MM; Jansen JC; Oomen PH; Menko FH; Pasini B; Ferrando B; Wong N; Alpert LC; Williams R; Blair E; Devilee P; Taschner PE
    BMC Med Genet; 2006 Jan; 7():1. PubMed ID: 16405730
    [TBL] [Abstract][Full Text] [Related]  

  • 12. No germline FH mutations in familial breast cancer patients.
    Kiuru M; Lehtonen R; Eerola H; Aittomäki K; Blomqvist C; Nevanlinna H; Aaltonen LA; Launonen V
    Eur J Hum Genet; 2005 Apr; 13(4):506-9. PubMed ID: 15523491
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?
    Laurenti G; Tennant DA
    Biochem Soc Trans; 2016 Aug; 44(4):1111-6. PubMed ID: 27528759
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.
    Vanharanta S; Pollard PJ; Lehtonen HJ; Laiho P; Sjöberg J; Leminen A; Aittomäki K; Arola J; Kruhoffer M; Orntoft TF; Tomlinson IP; Kiuru M; Arango D; Aaltonen LA
    Hum Mol Genet; 2006 Jan; 15(1):97-103. PubMed ID: 16319128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer.
    Alam NA; Olpin S; Leigh IM
    Br J Dermatol; 2005 Jul; 153(1):11-7. PubMed ID: 16029320
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms.
    Schaefer IM; Hornick JL; Bovée JVMG
    Lab Invest; 2018 Apr; 98(4):414-426. PubMed ID: 29339836
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A role for mitochondrial enzymes in inherited neoplasia and beyond.
    Eng C; Kiuru M; Fernandez MJ; Aaltonen LA
    Nat Rev Cancer; 2003 Mar; 3(3):193-202. PubMed ID: 12612654
    [TBL] [Abstract][Full Text] [Related]  

  • 18. No evidence for epigenetic inactivation of fumarate hydratase in leiomyomas and leiomyosarcomas.
    Barker KT; Spendlove HE; Banu NS; Bridge JA; Fisher C; Shipley J; Garrett M; Manyonda I; Houlston RS
    Cancer Lett; 2006 Apr; 235(1):136-40. PubMed ID: 15949892
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
    Xiao M; Yang H; Xu W; Ma S; Lin H; Zhu H; Liu L; Liu Y; Yang C; Xu Y; Zhao S; Ye D; Xiong Y; Guan KL
    Genes Dev; 2012 Jun; 26(12):1326-38. PubMed ID: 22677546
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fumarate hydratase deficiency and cancer: activation of hypoxia signaling?
    Ratcliffe PJ
    Cancer Cell; 2007 Apr; 11(4):303-5. PubMed ID: 17418405
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 38.