BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 15990302)

  • 1. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase.
    Sammond DM; Nailor KE; Veal JM; Nolte RT; Wang L; Knick VB; Rudolph SK; Truesdale AT; Nartey EN; Stafford JA; Kumar R; Cheung M
    Bioorg Med Chem Lett; 2005 Aug; 15(15):3519-23. PubMed ID: 15990302
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
    Dai Y; Guo Y; Frey RR; Ji Z; Curtin ML; Ahmed AA; Albert DH; Arnold L; Arries SS; Barlozzari T; Bauch JL; Bouska JJ; Bousquet PF; Cunha GA; Glaser KB; Guo J; Li J; Marcotte PA; Marsh KC; Moskey MD; Pease LJ; Stewart KD; Stoll VS; Tapang P; Wishart N; Davidsen SK; Michaelides MR
    J Med Chem; 2005 Sep; 48(19):6066-83. PubMed ID: 16162008
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.
    Miyazaki Y; Matsunaga S; Tang J; Maeda Y; Nakano M; Philippe RJ; Shibahara M; Liu W; Sato H; Wang L; Nolte RT
    Bioorg Med Chem Lett; 2005 May; 15(9):2203-7. PubMed ID: 15837294
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.
    Hughes TV; Emanuel SL; Beck AK; Wetter SK; Connolly PJ; Karnachi P; Reuman M; Seraj J; Fuentes-Pesquera AR; Gruninger RH; Middleton SA; Lin R; Davis JM; Moffat DF
    Bioorg Med Chem Lett; 2007 Jun; 17(12):3266-70. PubMed ID: 17481894
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups.
    Gaudette F; Raeppel S; Nguyen H; Beaulieu N; Beaulieu C; Dupont I; Macleod AR; Besterman JM; Vaisburg A
    Bioorg Med Chem Lett; 2010 Feb; 20(3):848-52. PubMed ID: 20071170
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
    Liu M; Wang S; Clampit JE; Gum RJ; Haasch DL; Rondinone CM; Trevillyan JM; Abad-Zapatero C; Fry EH; Sham HL; Liu G
    Bioorg Med Chem Lett; 2007 Feb; 17(3):668-72. PubMed ID: 17107797
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.
    Huang PP; Randolph JT; Klein LL; Vasavanonda S; Dekhtyar T; Stoll VS; Kempf DJ
    Bioorg Med Chem Lett; 2004 Aug; 14(15):4075-8. PubMed ID: 15225729
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors.
    Maeda Y; Nakano M; Sato H; Miyazaki Y; Schweiker SL; Smith JL; Truesdale AT
    Bioorg Med Chem Lett; 2004 Aug; 14(15):3907-11. PubMed ID: 15225695
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2.
    Miyazaki Y; Tang J; Maeda Y; Nakano M; Wang L; Nolte RT; Sato H; Sugai M; Okamoto Y; Truesdale AT; Hassler DF; Nartey EN; Patrick DR; Ho ML; Ozawa K
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1773-8. PubMed ID: 17276055
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
    Hamby JM; Connolly CJ; Schroeder MC; Winters RT; Showalter HD; Panek RL; Major TC; Olsewski B; Ryan MJ; Dahring T; Lu GH; Keiser J; Amar A; Shen C; Kraker AJ; Slintak V; Nelson JM; Fry DW; Bradford L; Hallak H; Doherty AM
    J Med Chem; 1997 Jul; 40(15):2296-303. PubMed ID: 9240345
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Isoindolinone ureas: a novel class of KDR kinase inhibitors.
    Curtin ML; Frey RR; Heyman HR; Sarris KA; Steinman DH; Holmes JH; Bousquet PF; Cunha GA; Moskey MD; Ahmed AA; Pease LJ; Glaser KB; Stewart KD; Davidsen SK; Michaelides MR
    Bioorg Med Chem Lett; 2004 Sep; 14(17):4505-9. PubMed ID: 15357981
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
    Claridge S; Raeppel F; Granger MC; Bernstein N; Saavedra O; Zhan L; Llewellyn D; Wahhab A; Deziel R; Rahil J; Beaulieu N; Nguyen H; Dupont I; Barsalou A; Beaulieu C; Chute I; Gravel S; Robert MF; Lefebvre S; Dubay M; Pascal R; Gillespie J; Jin Z; Wang J; Besterman JM; MacLeod AR; Vaisburg A
    Bioorg Med Chem Lett; 2008 May; 18(9):2793-8. PubMed ID: 18434145
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.
    Getman DP; DeCrescenzo GA; Heintz RM; Reed KL; Talley JJ; Bryant ML; Clare M; Houseman KA; Marr JJ; Mueller RA
    J Med Chem; 1993 Jan; 36(2):288-91. PubMed ID: 8423599
    [No Abstract]   [Full Text] [Related]  

  • 14. Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors.
    Becknell NC; Zulli AL; Angeles TS; Yang S; Albom MS; Aimone LD; Robinson C; Chang H; Hudkins RL
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5368-72. PubMed ID: 16890434
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1-P2 scaffold.
    Kazmierski WM; Furfine E; Gray-Nunez Y; Spaltenstein A; Wright L
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5685-7. PubMed ID: 15482948
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thienopyridine urea inhibitors of KDR kinase.
    Heyman HR; Frey RR; Bousquet PF; Cunha GA; Moskey MD; Ahmed AA; Soni NB; Marcotte PA; Pease LJ; Glaser KB; Yates M; Bouska JJ; Albert DH; Black-Schaefer CL; Dandliker PJ; Stewart KD; Rafferty P; Davidsen SK; Michaelides MR; Curtin ML
    Bioorg Med Chem Lett; 2007 Mar; 17(5):1246-9. PubMed ID: 17188869
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
    Schroeder MC; Hamby JM; Connolly CJ; Grohar PJ; Winters RT; Barvian MR; Moore CW; Boushelle SL; Crean SM; Kraker AJ; Driscoll DL; Vincent PW; Elliott WL; Lu GH; Batley BL; Dahring TK; Major TC; Panek RL; Doherty AM; Showalter HD
    J Med Chem; 2001 Jun; 44(12):1915-26. PubMed ID: 11384237
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
    Xin Z; Zhao H; Serby MD; Liu B; Liu M; Szczepankiewicz BG; Nelson LT; Smith HT; Suhar TS; Janis RS; Cao N; Camp HS; Collins CA; Sham HL; Surowy TK; Liu G
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4298-302. PubMed ID: 18632269
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.
    Bilodeau MT; Rodman LD; McGaughey GB; Coll KE; Koester TJ; Hoffman WF; Hungate RW; Kendall RL; McFall RC; Rickert KW; Rutledge RZ; Thomas KA
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2941-5. PubMed ID: 15125964
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
    Huang S; Li R; Connolly PJ; Xu G; Gaul MD; Emanuel SL; Lamontagne KR; Greenberger LM
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6063-6. PubMed ID: 16979339
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.