BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 15999993)

  • 1. Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.
    Harper S; Avolio S; Pacini B; Di Filippo M; Altamura S; Tomei L; Paonessa G; Di Marco S; Carfi A; Giuliano C; Padron J; Bonelli F; Migliaccio G; De Francesco R; Laufer R; Rowley M; Narjes F
    J Med Chem; 2005 Jul; 48(14):4547-57. PubMed ID: 15999993
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
    Harper S; Pacini B; Avolio S; Di Filippo M; Migliaccio G; Laufer R; De Francesco R; Rowley M; Narjes F
    J Med Chem; 2005 Mar; 48(5):1314-7. PubMed ID: 15743173
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
    Narjes F; Crescenzi B; Ferrara M; Habermann J; Colarusso S; Ferreira Mdel R; Stansfield I; Mackay AC; Conte I; Ercolani C; Zaramella S; Palumbi MC; Meuleman P; Leroux-Roels G; Giuliano C; Fiore F; Di Marco S; Baiocco P; Koch U; Migliaccio G; Altamura S; Laufer R; De Francesco R; Rowley M
    J Med Chem; 2011 Jan; 54(1):289-301. PubMed ID: 21141896
    [TBL] [Abstract][Full Text] [Related]  

  • 4. N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
    Beaulieu PL; Jolicoeur E; Gillard J; Brochu C; Coulombe R; Dansereau N; Duan J; Garneau M; Jakalian A; Kühn P; Lagacé L; LaPlante S; McKercher G; Perrault S; Poirier M; Poupart MA; Stammers T; Thauvette L; Thavonekham B; Kukolj G
    Bioorg Med Chem Lett; 2010 Feb; 20(3):857-61. PubMed ID: 20074949
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
    Laporte MG; Jackson RW; Draper TL; Gaboury JA; Galie K; Herbertz T; Hussey AR; Rippin SR; Benetatos CA; Chunduru SK; Christensen JS; Coburn GA; Rizzo CJ; Rhodes G; O'Connell J; Howe AY; Mansour TS; Collett MS; Pevear DC; Young DC; Gao T; Tyrrell DL; Kneteman NM; Burns CJ; Condon SM
    ChemMedChem; 2008 Oct; 3(10):1508-15. PubMed ID: 18729128
    [No Abstract]   [Full Text] [Related]  

  • 6. Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
    Lemm JA; Liu M; Gentles RG; Ding M; Voss S; Pelosi LA; Wang YK; Rigat KL; Mosure KW; Bender JA; Knipe JO; Colonno R; Meanwell NA; Kadow JF; Santone KS; Roberts SB; Gao M
    Antimicrob Agents Chemother; 2014 Jun; 58(6):3485-95. PubMed ID: 24733465
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.
    Jin G; Lee S; Choi M; Son S; Kim GW; Oh JW; Lee C; Lee K
    Eur J Med Chem; 2014 Mar; 75():413-25. PubMed ID: 24561671
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
    McGowan D; Vendeville S; Lin TI; Tahri A; Hu L; Cummings MD; Amssoms K; Berke JM; Canard M; Cleiren E; Dehertogh P; Last S; Fransen E; Van Der Helm E; Van den Steen I; Vijgen L; Rouan MC; Fanning G; Nyanguile O; Van Emelen K; Simmen K; Raboisson P
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4431-6. PubMed ID: 22542193
    [TBL] [Abstract][Full Text] [Related]  

  • 9. NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
    Bessa LM; Launay H; Dujardin M; Cantrelle FX; Lippens G; Landrieu I; Schneider R; Hanoulle X
    J Biol Chem; 2017 Nov; 292(44):18024-18043. PubMed ID: 28912275
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
    Beaulieu PL; Gillard J; Bykowski D; Brochu C; Dansereau N; Duceppe JS; Haché B; Jakalian A; Lagacé L; LaPlante S; McKercher G; Moreau E; Perreault S; Stammers T; Thauvette L; Warrington J; Kukolj G
    Bioorg Med Chem Lett; 2006 Oct; 16(19):4987-93. PubMed ID: 16908138
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.
    Ikegashira K; Oka T; Hirashima S; Noji S; Yamanaka H; Hara Y; Adachi T; Tsuruha J; Doi S; Hase Y; Noguchi T; Ando I; Ogura N; Ikeda S; Hashimoto H
    J Med Chem; 2006 Nov; 49(24):6950-3. PubMed ID: 17125247
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase.
    Martin Hernando JI; Ontoria JM; Malancona S; Attenni B; Fiore F; Bonelli F; Koch U; Di Marco S; Colarusso S; Ponzi S; Gennari N; Vignetti SE; Del Rosario Rico Ferreira M; Habermann J; Rowley M; Narjes F
    ChemMedChem; 2009 Oct; 4(10):1695-713. PubMed ID: 19672916
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.
    Rigat KL; Lu H; Wang YK; Argyrou A; Fanslau C; Beno B; Wang Y; Marcinkeviciene J; Ding M; Gentles RG; Gao M; Abell LM; Roberts SB
    J Biol Chem; 2014 Nov; 289(48):33456-68. PubMed ID: 25301950
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
    Gopalsamy A; Lim K; Ciszewski G; Park K; Ellingboe JW; Bloom J; Insaf S; Upeslacis J; Mansour TS; Krishnamurthy G; Damarla M; Pyatski Y; Ho D; Howe AY; Orlowski M; Feld B; O'Connell J
    J Med Chem; 2004 Dec; 47(26):6603-8. PubMed ID: 15588095
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.
    Vandyck K; Cummings MD; Nyanguile O; Boutton CW; Vendeville S; McGowan D; Devogelaere B; Amssoms K; Last S; Rombauts K; Tahri A; Lory P; Hu L; Beauchamp DA; Simmen K; Raboisson P
    J Med Chem; 2009 Jul; 52(14):4099-102. PubMed ID: 19507864
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
    Schoenfeld RC; Bourdet DL; Brameld KA; Chin E; de Vicente J; Fung A; Harris SF; Lee EK; Le Pogam S; Leveque V; Li J; Lui AS; Najera I; Rajyaguru S; Sangi M; Steiner S; Talamas FX; Taygerly JP; Zhao J
    J Med Chem; 2013 Oct; 56(20):8163-82. PubMed ID: 24069953
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
    Sofia MJ; Chang W; Furman PA; Mosley RT; Ross BS
    J Med Chem; 2012 Mar; 55(6):2481-531. PubMed ID: 22185586
    [No Abstract]   [Full Text] [Related]  

  • 18. Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.
    Hirashima S; Suzuki T; Ishida T; Noji S; Yata S; Ando I; Komatsu M; Ikeda S; Hashimoto H
    J Med Chem; 2006 Jul; 49(15):4721-36. PubMed ID: 16854079
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
    Chen KX; Vibulbhan B; Yang W; Sannigrahi M; Velazquez F; Chan TY; Venkatraman S; Anilkumar GN; Zeng Q; Bennet F; Jiang Y; Lesburg CA; Duca J; Pinto P; Gavalas S; Huang Y; Wu W; Selyutin O; Agrawal S; Feld B; Huang HC; Li C; Cheng KC; Shih NY; Kozlowski JA; Rosenblum SB; Njoroge FG
    J Med Chem; 2012 Jan; 55(2):754-65. PubMed ID: 22148957
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ligand-induced changes in hepatitis C virus NS5B polymerase structure.
    Rigat K; Wang Y; Hudyma TW; Ding M; Zheng X; Gentles RG; Beno BR; Gao M; Roberts SB
    Antiviral Res; 2010 Nov; 88(2):197-206. PubMed ID: 20813137
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.