BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 16000004)

  • 1. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.
    Evans GB; Furneaux RH; Lenz DH; Painter GF; Schramm VL; Singh V; Tyler PC
    J Med Chem; 2005 Jul; 48(14):4679-89. PubMed ID: 16000004
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
    Evans GB; Furneaux RH; Schramm VL; Singh V; Tyler PC
    J Med Chem; 2004 Jun; 47(12):3275-81. PubMed ID: 15163207
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
    Singh V; Shi W; Evans GB; Tyler PC; Furneaux RH; Almo SC; Schramm VL
    Biochemistry; 2004 Jan; 43(1):9-18. PubMed ID: 14705926
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of a potent transition-state inhibitor of 5'-deoxy-5'-methylthioadenosine phosphorylase.
    Kamath VP; Ananth S; Bantia S; Morris PE
    J Med Chem; 2004 Mar; 47(6):1322-4. PubMed ID: 14998321
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
    Evans GB; Furneaux RH; Lewandowicz A; Schramm VL; Tyler PC
    J Med Chem; 2003 Nov; 46(24):5271-6. PubMed ID: 14613329
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
    Evans GB; Furneaux RH; Greatrex B; Murkin AS; Schramm VL; Tyler PC
    J Med Chem; 2008 Feb; 51(4):948-56. PubMed ID: 18251493
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase.
    Longshaw AI; Adanitsch F; Gutierrez JA; Evans GB; Tyler PC; Schramm VL
    J Med Chem; 2010 Sep; 53(18):6730-46. PubMed ID: 20718423
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.
    Guan R; Ho MC; Brenowitz M; Tyler PC; Evans GB; Almo SC; Schramm VL
    Biochemistry; 2011 Nov; 50(47):10408-17. PubMed ID: 21985704
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase.
    Guan R; Tyler PC; Evans GB; Schramm VL
    Biochemistry; 2013 Nov; 52(46):8313-22. PubMed ID: 24148083
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Transition state analogues in quorum sensing and SAM recycling.
    Schramm VL; Gutierrez JA; Cordovano G; Basu I; Guha C; Belbin TJ; Evans GB; Tyler PC; Furneaux RH
    Nucleic Acids Symp Ser (Oxf); 2008; (52):75-6. PubMed ID: 18776260
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
    Namanja-Magliano HA; Evans GB; Harijan RK; Tyler PC; Schramm VL
    Biochemistry; 2017 Sep; 56(38):5090-5098. PubMed ID: 28836767
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
    Basu I; Locker J; Cassera MB; Belbin TJ; Merino EF; Dong X; Hemeon I; Evans GB; Guha C; Schramm VL
    J Biol Chem; 2011 Feb; 286(6):4902-11. PubMed ID: 21135097
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis.
    Appleby TC; Erion MD; Ealick SE
    Structure; 1999 Jun; 7(6):629-41. PubMed ID: 10404592
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transition state analogue of MTAP extends lifespan of APC
    Firestone RS; Feng M; Basu I; Peregrina K; Augenlicht LH; Schramm VL
    Sci Rep; 2021 Apr; 11(1):8844. PubMed ID: 33893330
    [TBL] [Abstract][Full Text] [Related]  

  • 15. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
    Miles RW; Tyler PC; Furneaux RH; Bagdassarian CK; Schramm VL
    Biochemistry; 1998 Jun; 37(24):8615-21. PubMed ID: 9628722
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
    Lee JE; Settembre EC; Cornell KA; Riscoe MK; Sufrin JR; Ealick SE; Howell PL
    Biochemistry; 2004 May; 43(18):5159-69. PubMed ID: 15122881
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy.
    Chen ZH; Zhang H; Savarese TM
    Cancer Res; 1996 Mar; 56(5):1083-90. PubMed ID: 8640765
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
    Rinaldo-Matthis A; Wing C; Ghanem M; Deng H; Wu P; Gupta A; Tyler PC; Evans GB; Furneaux RH; Almo SC; Wang CC; Schramm VL
    Biochemistry; 2007 Jan; 46(3):659-68. PubMed ID: 17223688
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.
    Chen ZH; Olopade OI; Savarese TM
    Mol Pharmacol; 1997 Nov; 52(5):903-11. PubMed ID: 9351982
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transition states and inhibitors of the purine nucleoside phosphorylase family.
    Taylor Ringia EA; Schramm VL
    Curr Top Med Chem; 2005; 5(13):1237-58. PubMed ID: 16305529
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.