483 related articles for article (PubMed ID: 16007177)
1. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells.
Wallick CJ; Gamper I; Thorne M; Feith DJ; Takasaki KY; Wilson SM; Seki JA; Pegg AE; Byus CV; Bachmann AS
Oncogene; 2005 Aug; 24(36):5606-18. PubMed ID: 16007177
[TBL] [Abstract][Full Text] [Related]
2. AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.
Samal K; Zhao P; Kendzicky A; Yco LP; McClung H; Gerner E; Burns M; Bachmann AS; Sholler G
Int J Cancer; 2013 Sep; 133(6):1323-33. PubMed ID: 23457004
[TBL] [Abstract][Full Text] [Related]
3. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
Koomoa DL; Geerts D; Lange I; Koster J; Pegg AE; Feith DJ; Bachmann AS
Int J Oncol; 2013 Apr; 42(4):1219-28. PubMed ID: 23440295
[TBL] [Abstract][Full Text] [Related]
4. Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.
Koomoa DL; Yco LP; Borsics T; Wallick CJ; Bachmann AS
Cancer Res; 2008 Dec; 68(23):9825-31. PubMed ID: 19047162
[TBL] [Abstract][Full Text] [Related]
5. Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.
Kramer DL; Chang BD; Chen Y; Diegelman P; Alm K; Black AR; Roninson IB; Porter CW
Cancer Res; 2001 Nov; 61(21):7754-62. PubMed ID: 11691789
[TBL] [Abstract][Full Text] [Related]
6. Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.
Rounbehler RJ; Li W; Hall MA; Yang C; Fallahi M; Cleveland JL
Cancer Res; 2009 Jan; 69(2):547-53. PubMed ID: 19147568
[TBL] [Abstract][Full Text] [Related]
7. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
Schultz CR; Geerts D; Mooney M; El-Khawaja R; Koster J; Bachmann AS
Biochem J; 2018 Jan; 475(2):531-545. PubMed ID: 29295892
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.
Koomoa DL; Borsics T; Feith DJ; Coleman CC; Wallick CJ; Gamper I; Pegg AE; Bachmann AS
Mol Cancer Ther; 2009 Jul; 8(7):2067-75. PubMed ID: 19584241
[TBL] [Abstract][Full Text] [Related]
9. Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes.
Ravanko K; Järvinen K; Paasinen-Sohns A; Hölttä E
Cancer Res; 2000 Sep; 60(18):5244-53. PubMed ID: 11016654
[TBL] [Abstract][Full Text] [Related]
10. Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest.
Yaari S; Jacob-Hirsch J; Amariglio N; Haklai R; Rechavi G; Kloog Y
Clin Cancer Res; 2005 Jun; 11(12):4321-30. PubMed ID: 15958613
[TBL] [Abstract][Full Text] [Related]
11. Increased expression of p27Kip1 arrests neuroblastoma cell growth.
Matsuo T; Seth P; Thiele CJ
Med Pediatr Oncol; 2001 Jan; 36(1):97-9. PubMed ID: 11464914
[TBL] [Abstract][Full Text] [Related]
12. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Matters GL; Manni A; Bond JS
Clin Exp Metastasis; 2005; 22(4):331-9. PubMed ID: 16170669
[TBL] [Abstract][Full Text] [Related]
13. ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.
Hogarty MD; Norris MD; Davis K; Liu X; Evageliou NF; Hayes CS; Pawel B; Guo R; Zhao H; Sekyere E; Keating J; Thomas W; Cheng NC; Murray J; Smith J; Sutton R; Venn N; London WB; Buxton A; Gilmour SK; Marshall GM; Haber M
Cancer Res; 2008 Dec; 68(23):9735-45. PubMed ID: 19047152
[TBL] [Abstract][Full Text] [Related]
14. Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.
Hu X; Washington S; Verderame MF; Demers LM; Mauger D; Manni A
Int J Oncol; 2004 Dec; 25(6):1831-8. PubMed ID: 15547724
[TBL] [Abstract][Full Text] [Related]
15. CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.
Gogolin S; Ehemann V; Becker G; Brueckner LM; Dreidax D; Bannert S; Nolte I; Savelyeva L; Bell E; Westermann F
Cell Cycle; 2013 Apr; 12(7):1091-104. PubMed ID: 23462184
[TBL] [Abstract][Full Text] [Related]
16. SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.
Evans L; Chen L; Milazzo G; Gherardi S; Perini G; Willmore E; Newell DR; Tweddle DA
Cancer Lett; 2015 Jul; 363(1):37-45. PubMed ID: 25843293
[TBL] [Abstract][Full Text] [Related]
17. The role of polyamines in human cancer: prospects for drug combination therapies.
Bachmann AS
Hawaii Med J; 2004 Dec; 63(12):371-4. PubMed ID: 15704548
[TBL] [Abstract][Full Text] [Related]
18. Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle.
Yamashita T; Nishimura K; Saiki R; Okudaira H; Tome M; Higashi K; Nakamura M; Terui Y; Fujiwara K; Kashiwagi K; Igarashi K
Int J Biochem Cell Biol; 2013 Jun; 45(6):1042-50. PubMed ID: 23500523
[TBL] [Abstract][Full Text] [Related]
19. Effects of antisense RNA targeting of ODC and AdoMetDC on the synthesis of polyamine synthesis and cell growth in prostate cancer cells using a prostatic androgen-dependent promoter in adenovirus.
Li W; Liu X; Wang W; Sun H; Hu Y; Lei H; Liu G; Gao Y
Prostate; 2008 Sep; 68(12):1354-61. PubMed ID: 18548481
[TBL] [Abstract][Full Text] [Related]
20. MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.
Petroni M; Veschi V; Prodosmo A; Rinaldo C; Massimi I; Carbonari M; Dominici C; McDowell HP; Rinaldi C; Screpanti I; Frati L; Bartolazzi A; Gulino A; Soddu S; Giannini G
Mol Cancer Res; 2011 Jan; 9(1):67-77. PubMed ID: 21173028
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]