281 related articles for article (PubMed ID: 16008527)
1. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
Ariyanayagam MR; Oza SL; Guther ML; Fairlamb AH
Biochem J; 2005 Oct; 391(Pt 2):425-32. PubMed ID: 16008527
[TBL] [Abstract][Full Text] [Related]
2. Trypanothione biosynthesis in Leishmania major.
Oza SL; Shaw MP; Wyllie S; Fairlamb AH
Mol Biochem Parasitol; 2005 Jan; 139(1):107-16. PubMed ID: 15610825
[TBL] [Abstract][Full Text] [Related]
3. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Wyllie S; Oza SL; Patterson S; Spinks D; Thompson S; Fairlamb AH
Mol Microbiol; 2009 Nov; 74(3):529-40. PubMed ID: 19558432
[TBL] [Abstract][Full Text] [Related]
4. Validation of Trypanosoma brucei trypanothione synthetase as drug target.
Comini MA; Guerrero SA; Haile S; Menge U; Lünsdorf H; Flohé L
Free Radic Biol Med; 2004 May; 36(10):1289-302. PubMed ID: 15110394
[TBL] [Abstract][Full Text] [Related]
5. Properties of trypanothione synthetase from Trypanosoma brucei.
Oza SL; Ariyanayagam MR; Aitcheson N; Fairlamb AH
Mol Biochem Parasitol; 2003 Sep; 131(1):25-33. PubMed ID: 12967709
[TBL] [Abstract][Full Text] [Related]
6. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
Oza SL; Tetaud E; Ariyanayagam MR; Warnon SS; Fairlamb AH
J Biol Chem; 2002 Sep; 277(39):35853-61. PubMed ID: 12121990
[TBL] [Abstract][Full Text] [Related]
7. Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.
Sousa AF; Gomes-Alves AG; Benítez D; Comini MA; Flohé L; Jaeger T; Passos J; Stuhlmann F; Tomás AM; Castro H
Free Radic Biol Med; 2014 Aug; 73():229-38. PubMed ID: 24853758
[TBL] [Abstract][Full Text] [Related]
8. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
González-Chávez Z; Vázquez C; Mejia-Tlachi M; Márquez-Dueñas C; Manning-Cela R; Encalada R; Rodríguez-Enríquez S; Michels PAM; Moreno-Sánchez R; Saavedra E
Redox Biol; 2019 Sep; 26():101231. PubMed ID: 31203195
[TBL] [Abstract][Full Text] [Related]
9. Trypanothione synthesis in crithidia revisited.
Comini M; Menge U; Wissing J; Flohé L
J Biol Chem; 2005 Feb; 280(8):6850-60. PubMed ID: 15537651
[TBL] [Abstract][Full Text] [Related]
10. Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei.
Shahi SK; Krauth-Siegel RL; Clayton CE
Mol Microbiol; 2002 Mar; 43(5):1129-38. PubMed ID: 11918801
[TBL] [Abstract][Full Text] [Related]
11. Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
Zimmermann S; Oufir M; Leroux A; Krauth-Siegel RL; Becker K; Kaiser M; Brun R; Hamburger M; Adams M
Bioorg Med Chem; 2013 Nov; 21(22):7202-9. PubMed ID: 24080104
[TBL] [Abstract][Full Text] [Related]
12. Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.
Fairlamb AH; Carter NS; Cunningham M; Smith K
Mol Biochem Parasitol; 1992 Jul; 53(1-2):213-22. PubMed ID: 1501641
[TBL] [Abstract][Full Text] [Related]
13. A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes.
Ebersoll S; Bogacz M; Günter LM; Dick TP; Krauth-Siegel RL
Elife; 2020 Jan; 9():. PubMed ID: 32003744
[TBL] [Abstract][Full Text] [Related]
14. Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Nishimura K; Yanase T; Araki N; Ohnishi Y; Kozaki S; Shima K; Asakura M; Samosomsuk W; Yamasaki S
J Parasitol; 2006 Apr; 92(2):211-7. PubMed ID: 16729674
[TBL] [Abstract][Full Text] [Related]
15. Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
Huynh TT; Huynh VT; Harmon MA; Phillips MA
J Biol Chem; 2003 Oct; 278(41):39794-800. PubMed ID: 12888552
[TBL] [Abstract][Full Text] [Related]
16. Preparative enzymatic synthesis of trypanothione and trypanothione analogues.
Comini MA; Dirdjaja N; Kaschel M; Krauth-Siegel RL
Int J Parasitol; 2009 Aug; 39(10):1059-62. PubMed ID: 19477177
[TBL] [Abstract][Full Text] [Related]
17. Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase.
Koch O; Cappel D; Nocker M; Jäger T; Flohé L; Sotriffer CA; Selzer PM
PLoS One; 2013; 8(2):e56788. PubMed ID: 23451087
[TBL] [Abstract][Full Text] [Related]
18. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.
Fairlamb AH; Henderson GB; Bacchi CJ; Cerami A
Mol Biochem Parasitol; 1987 Jun; 24(2):185-91. PubMed ID: 3114634
[TBL] [Abstract][Full Text] [Related]
19. Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
Augustyns K; Amssoms K; Yamani A; Rajan PK; Haemers A
Curr Pharm Des; 2001 Aug; 7(12):1117-41. PubMed ID: 11472257
[TBL] [Abstract][Full Text] [Related]
20. Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.
Benítez D; Medeiros A; Fiestas L; Panozzo-Zenere EA; Maiwald F; Prousis KC; Roussaki M; Calogeropoulou T; Detsi A; Jaeger T; Šarlauskas J; Peterlin Mašič L; Kunick C; Labadie GR; Flohé L; Comini MA
PLoS Negl Trop Dis; 2016 Apr; 10(4):e0004617. PubMed ID: 27070550
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]