119 related articles for article (PubMed ID: 16023344)
1. Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Mellon C; Aspiotis R; Black CW; Bayly CI; Grimm EL; Giroux A; Han Y; Isabel E; McKay DJ; Nicholson DW; Rasper DM; Roy S; Tam J; Thornberry NA; Vaillancourt JP; Xanthoudakis S; Zamboni R
Bioorg Med Chem Lett; 2005 Sep; 15(17):3886-90. PubMed ID: 16023344
[TBL] [Abstract][Full Text] [Related]
2. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.
Cai SX; Guan L; Jia S; Wang Y; Yang W; Tseng B; Drewe J
Bioorg Med Chem Lett; 2004 Nov; 14(21):5295-300. PubMed ID: 15454214
[TBL] [Abstract][Full Text] [Related]
3. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.
Wang Y; Jia S; Tseng B; Drewe J; Cai SX
Bioorg Med Chem Lett; 2007 Nov; 17(22):6178-82. PubMed ID: 17889532
[TBL] [Abstract][Full Text] [Related]
4. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.
Wang Y; Guan L; Jia S; Tseng B; Drewe J; Cai SX
Bioorg Med Chem Lett; 2005 Mar; 15(5):1379-83. PubMed ID: 15713391
[TBL] [Abstract][Full Text] [Related]
5. Nicotinyl aspartyl ketones as inhibitors of caspase-3.
Isabel E; Black WC; Bayly CI; Grimm EL; Janes MK; McKay DJ; Nicholson DW; Rasper DM; Renaud J; Roy S; Tam J; Thornberry NA; Vaillancourt JP; Xanthoudakis S; Zamboni R
Bioorg Med Chem Lett; 2003 Jul; 13(13):2137-40. PubMed ID: 12798321
[TBL] [Abstract][Full Text] [Related]
6. Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Han Y; Giroux A; Grimm EL; Aspiotis R; Francoeur S; Bayly CI; Mckay DJ; Roy S; Xanthoudakis S; Vaillancourt JP; Rasper DM; Tam J; Tawa P; Thornberry NA; Paterson EP; Garcia-Calvo M; Becker JW; Rotonda J; Nicholson DW; Zamboni RJ
Bioorg Med Chem Lett; 2004 Feb; 14(3):805-8. PubMed ID: 14741294
[TBL] [Abstract][Full Text] [Related]
7. Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Wang Y; Huang JC; Zhou ZL; Yang W; Guastella J; Drewe J; Cai SX
Bioorg Med Chem Lett; 2004 Mar; 14(5):1269-72. PubMed ID: 14980679
[TBL] [Abstract][Full Text] [Related]
8. Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.
Ullman BR; Aja T; Chen N; Diaz JL; Gu X; Herrmann J; Kalish VJ; Karanewsky DS; Kodandapani L; Krebs JJ; Linton SD; Meduna SP; Nalley K; Robinson ED; Roggo SP; Sayers RO; Schmitz A; Ternansky RJ; Tomaselli KJ; Wu JC
Bioorg Med Chem Lett; 2005 Aug; 15(15):3632-6. PubMed ID: 15964758
[TBL] [Abstract][Full Text] [Related]
9. Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7.
Goode DR; Sharma AK; Hergenrother PJ
Org Lett; 2005 Aug; 7(16):3529-32. PubMed ID: 16048334
[TBL] [Abstract][Full Text] [Related]
10. Solid phase synthesis of selective caspase-3 peptide inhibitors.
Grimm EL; Roy B; Aspiotis R; Bayly CI; Nicholson DW; Rasper DM; Renaud J; Roy S; Tam J; Tawa P; Vaillancourt JP; Xanthoudakis S; Zamboni RJ
Bioorg Med Chem; 2004 Mar; 12(5):845-51. PubMed ID: 14980595
[TBL] [Abstract][Full Text] [Related]
11. Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD; Aja T; Allegrini PR; Deckwerth TL; Diaz JL; Hengerer B; Herrmann J; Jahangiri KG; Kallen J; Karanewsky DS; Meduna SP; Nalley K; Robinson ED; Roggo S; Rovelli G; Sauter A; Sayers RO; Schmitz A; Smidt R; Ternansky RJ; Tomaselli KJ; Ullman BR; Wiessner C; Wu JC
Bioorg Med Chem Lett; 2004 May; 14(10):2685-91. PubMed ID: 15109679
[TBL] [Abstract][Full Text] [Related]
12. Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.
Black WC; Bayly CI; Davis DE; Desmarais S; Falgueyret JP; Léger S; Li CS; Massé F; McKay DJ; Palmer JT; Percival MD; Robichaud J; Tsou N; Zamboni R
Bioorg Med Chem Lett; 2005 Nov; 15(21):4741-4. PubMed ID: 16154747
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors.
Nedev HN; Klaiman G; LeBlanc A; Saragovi HU
Biochem Biophys Res Commun; 2005 Oct; 336(2):397-400. PubMed ID: 16137654
[TBL] [Abstract][Full Text] [Related]
14. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Becker JW; Rotonda J; Soisson SM; Aspiotis R; Bayly C; Francoeur S; Gallant M; Garcia-Calvo M; Giroux A; Grimm E; Han Y; McKay D; Nicholson DW; Peterson E; Renaud J; Roy S; Thornberry N; Zamboni R
J Med Chem; 2004 May; 47(10):2466-74. PubMed ID: 15115390
[TBL] [Abstract][Full Text] [Related]
15. 1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors.
Kravchenko DV; Kysil VV; Ilyn AP; Tkachenko SE; Maliarchouk S; Okun IM; Ivachtchenko AV
Bioorg Med Chem Lett; 2005 Apr; 15(7):1841-5. PubMed ID: 15780618
[TBL] [Abstract][Full Text] [Related]
16. Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Isabel E; Aspiotis R; Black WC; Colucci J; Fortin R; Giroux A; Grimm EL; Han Y; Mellon C; Nicholson DW; Rasper DM; Renaud J; Roy S; Tam J; Tawa P; Vaillancourt JP; Xanthoudakis S; Zamboni RJ
Bioorg Med Chem Lett; 2007 Mar; 17(6):1671-4. PubMed ID: 17251019
[TBL] [Abstract][Full Text] [Related]
17. In situ assembly of enzyme inhibitors using extended tethering.
Erlanson DA; Lam JW; Wiesmann C; Luong TN; Simmons RL; DeLano WL; Choong IC; Burdett MT; Flanagan WM; Lee D; Gordon EM; O'Brien T
Nat Biotechnol; 2003 Mar; 21(3):308-14. PubMed ID: 12563278
[TBL] [Abstract][Full Text] [Related]
18. Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.
Tawa P; Giroux A; Grimm E; Han Y; Nicholson DW; Xanthoudakis S
Anal Biochem; 2006 Mar; 350(1):32-40. PubMed ID: 16430849
[TBL] [Abstract][Full Text] [Related]
19. Dipeptide nitrile inhibitors of cathepsin K.
Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Lattmann R; Missbach M
Bioorg Med Chem Lett; 2006 May; 16(9):2549-54. PubMed ID: 16480867
[TBL] [Abstract][Full Text] [Related]
20. Novel trifluoromethyl ketones as potent gastric lipase inhibitors.
Kokotos G; Kotsovolou S; Verger R
Chembiochem; 2003 Jan; 4(1):90-5. PubMed ID: 12512081
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
