BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

261 related articles for article (PubMed ID: 16027727)

  • 1. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
    Steinman HA; Hoover KM; Keeler ML; Sands AT; Jones SN
    Oncogene; 2005 Nov; 24(53):7935-40. PubMed ID: 16027727
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
    Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G
    Mol Cell Biol; 2006 Jan; 26(1):192-8. PubMed ID: 16354690
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
    Parant J; Chavez-Reyes A; Little NA; Yan W; Reinke V; Jochemsen AG; Lozano G
    Nat Genet; 2001 Sep; 29(1):92-5. PubMed ID: 11528400
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
    Chandler DS; Singh RK; Caldwell LC; Bitler JL; Lozano G
    Cancer Res; 2006 Oct; 66(19):9502-8. PubMed ID: 17018606
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
    Chavez-Reyes A; Parant JM; Amelse LL; de Oca Luna RM; Korsmeyer SJ; Lozano G
    Cancer Res; 2003 Dec; 63(24):8664-9. PubMed ID: 14695178
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.
    Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G
    J Pathol; 2012 Nov; 228(3):416-28. PubMed ID: 22821713
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
    Iwakuma T; Parant JM; Fasulo M; Zwart E; Jacks T; de Vries A; Lozano G
    Oncogene; 2004 Oct; 23(46):7644-50. PubMed ID: 15361844
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
    Xiong S; Van Pelt CS; Elizondo-Fraire AC; Liu G; Lozano G
    Proc Natl Acad Sci U S A; 2006 Feb; 103(9):3226-31. PubMed ID: 16492743
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.
    Qi DL; Cobrinik D
    Oncogene; 2017 Mar; 36(13):1760-1769. PubMed ID: 27748758
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
    Francoz S; Froment P; Bogaerts S; De Clercq S; Maetens M; Doumont G; Bellefroid E; Marine JC
    Proc Natl Acad Sci U S A; 2006 Feb; 103(9):3232-7. PubMed ID: 16492744
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mdm2 and Mdm4 loss regulates distinct p53 activities.
    Barboza JA; Iwakuma T; Terzian T; El-Naggar AK; Lozano G
    Mol Cancer Res; 2008 Jun; 6(6):947-54. PubMed ID: 18567799
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mouse models of Mdm2 and Mdm4 and their clinical implications.
    Xiong S
    Chin J Cancer; 2013 Jul; 32(7):371-5. PubMed ID: 23327795
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
    Terzian T; Wang Y; Van Pelt CS; Box NF; Travis EL; Lozano G
    Mol Cell Biol; 2007 Aug; 27(15):5479-85. PubMed ID: 17526734
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells.
    Imanishi M; Yamamoto Y; Wang X; Sugaya A; Hirose M; Endo S; Natori Y; Yamato K; Hyodo I
    Cancer Sci; 2019 Feb; 110(2):639-649. PubMed ID: 30488540
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
    Toledo F; Krummel KA; Lee CJ; Liu CW; Rodewald LW; Tang M; Wahl GM
    Cancer Cell; 2006 Apr; 9(4):273-85. PubMed ID: 16616333
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
    Pant V; Xiong S; Iwakuma T; Quintás-Cardama A; Lozano G
    Proc Natl Acad Sci U S A; 2011 Jul; 108(29):11995-2000. PubMed ID: 21730132
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death.
    Boesten LS; Zadelaar SM; De Clercq S; Francoz S; van Nieuwkoop A; Biessen EA; Hofmann F; Feil S; Feil R; Jochemsen AG; Zurcher C; Havekes LM; van Vlijmen BJ; Marine JC
    Cell Death Differ; 2006 Dec; 13(12):2089-98. PubMed ID: 16729027
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.
    Swetzig WM; Wang J; Das GM
    Oncotarget; 2016 Mar; 7(13):16049-69. PubMed ID: 26909605
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.
    Giglio S; Mancini F; Pellegrino M; Di Conza G; Puxeddu E; Sacchi A; Pontecorvi A; Moretti F
    Oncogene; 2010 Nov; 29(44):5935-45. PubMed ID: 20697359
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish.
    Chua JS; Liew HP; Guo L; Lane DP
    Oncogene; 2015 Nov; 34(48):5933-41. PubMed ID: 25746004
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.