183 related articles for article (PubMed ID: 16033266)
1. Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
Moreira R; Santana AB; Iley J; Neres J; Douglas KT; Horton PN; Hursthouse MB
J Med Chem; 2005 Jul; 48(15):4861-70. PubMed ID: 16033266
[TBL] [Abstract][Full Text] [Related]
2. 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Mulchande J; Oliveira R; Carrasco M; Gouveia L; Guedes RC; Iley J; Moreira R
J Med Chem; 2010 Jan; 53(1):241-53. PubMed ID: 19904934
[TBL] [Abstract][Full Text] [Related]
3. Binding pockets on the surface of human leukocyte elastase and human leukocyte cathepsin G. Implications to the design of inhibitors derived from human C-reactive protein.
Yavin EJ; Eisenstein M; Fridkin M
Biomed Pept Proteins Nucleic Acids; 1996-1997; 2(3):71-8. PubMed ID: 9575343
[TBL] [Abstract][Full Text] [Related]
4. Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.
Mulchande J; Guedes RC; Tsang WY; Page MI; Moreira R; Iley J
J Med Chem; 2008 Mar; 51(6):1783-90. PubMed ID: 18290604
[TBL] [Abstract][Full Text] [Related]
5. Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives.
Portevin B; Lonchampt M; Canet E; De Nanteuil G
J Med Chem; 1997 Jun; 40(12):1906-18. PubMed ID: 9191969
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors.
Gérard S; Galleni M; Dive G; Marchand-Brynaert J
Bioorg Med Chem; 2004 Jan; 12(1):129-38. PubMed ID: 14697778
[TBL] [Abstract][Full Text] [Related]
7. 4-Alkyliden-beta-lactams conjugated to polyphenols: synthesis and inhibitory activity.
Cainelli G; Galletti P; Garbisa S; Giacomini D; Sartor L; Quintavalla A
Bioorg Med Chem; 2005 Nov; 13(22):6120-32. PubMed ID: 16084102
[TBL] [Abstract][Full Text] [Related]
8. 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Plantan I; Selic L; Mesar T; Anderluh PS; Oblak M; Prezelj A; Hesse L; Andrejasic M; Vilar M; Turk D; Kocijan A; Prevec T; Vilfan G; Kocjan D; Copar A; Urleb U; Solmajer T
J Med Chem; 2007 Aug; 50(17):4113-21. PubMed ID: 17665896
[TBL] [Abstract][Full Text] [Related]
9. Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.
Estácio SG; Moreira R; Guedes RC
J Chem Inf Model; 2011 Jul; 51(7):1690-702. PubMed ID: 21639142
[TBL] [Abstract][Full Text] [Related]
10. Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones.
Finke PE; Shah SK; Fletcher DS; Ashe BM; Brause KA; Chandler GO; Dellea PS; Hand KM; Maycock AL; Osinga DG
J Med Chem; 1995 Jun; 38(13):2449-62. PubMed ID: 7608910
[TBL] [Abstract][Full Text] [Related]
11. In vitro evaluation of the antielastase activity of polycyclic β-lactams.
Monleón LM; Díez-García F; Zamora H; Anaya J; Grande M; de Diego JG; Rodríguez FD
Bioorg Chem; 2012 Dec; 45():29-35. PubMed ID: 23064125
[TBL] [Abstract][Full Text] [Related]
12. Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase.
Gütschow M; Neumann U
J Med Chem; 1998 May; 41(10):1729-40. PubMed ID: 9572899
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones.
Macchia B; Gentili D; Macchia M; Mamone F; Martinelli A; Orlandini E; Rossello A; Cercignani G; Pierotti R; Allegretti M; Asti C; Caselli G
Eur J Med Chem; 2000 Jan; 35(1):53-67. PubMed ID: 10733603
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase.
Mulchande J; Simões SI; Gaspar MM; Eleutério CV; Oliveira R; Cruz ME; Moreira R; Iley J
J Enzyme Inhib Med Chem; 2011 Apr; 26(2):169-75. PubMed ID: 20545486
[TBL] [Abstract][Full Text] [Related]
15. Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process.
Wei L; Lai Z; Gan X; Alliston KR; Zhong J; Epp JB; Tu J; Perera AB; Van Stipdonk M; Groutas WC
Arch Biochem Biophys; 2004 Sep; 429(1):60-70. PubMed ID: 15288810
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
Borthwick AD; Davies DE; Ertl PF; Exall AM; Haley TM; Hart GJ; Jackson DL; Parry NR; Patikis A; Trivedi N; Weingarten GG; Woolven JM
J Med Chem; 2003 Oct; 46(21):4428-49. PubMed ID: 14521407
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and mechanism of action of novel thiocarbamate inhibitors of human leukocyte elastase.
Li-Pan ZS; Joshi HV; Digenis GA
J Enzyme Inhib; 2000; 15(1):63-77. PubMed ID: 10850955
[TBL] [Abstract][Full Text] [Related]
18. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.
Buynak JD; Rao AS; Ford GP; Carver C; Adam G; Geng B; Bachmann B; Shobassy S; Lackey S
J Med Chem; 1997 Oct; 40(21):3423-33. PubMed ID: 9341917
[TBL] [Abstract][Full Text] [Related]
19. Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
Chen KX; Njoroge FG; Arasappan A; Venkatraman S; Vibulbhan B; Yang W; Parekh TN; Pichardo J; Prongay A; Cheng KC; Butkiewicz N; Yao N; Madison V; Girijavallabhan V
J Med Chem; 2006 Feb; 49(3):995-1005. PubMed ID: 16451065
[TBL] [Abstract][Full Text] [Related]
20. Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
Wilmouth RC; Kassamally S; Westwood NJ; Sheppard RJ; Claridge TD; Aplin RT; Wright PA; Pritchard GJ; Schofield CJ
Biochemistry; 1999 Jun; 38(25):7989-98. PubMed ID: 10387042
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
