130 related articles for article (PubMed ID: 16039122)
1. Influence of acid surrogates toward potency of VLA-4 antagonist.
Venkatraman S; Lim J; Cramer M; Gardner MF; James J; Alves K; Lingham RB; Mumford RA; Munoz B
Bioorg Med Chem Lett; 2005 Sep; 15(18):4053-6. PubMed ID: 16039122
[TBL] [Abstract][Full Text] [Related]
2. A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Muro F; Iimura S; Yoneda Y; Chiba J; Watanabe T; Setoguchi M; Takayama G; Yokoyama M; Takashi T; Nakayama A; Machinaga N
Bioorg Med Chem; 2009 Feb; 17(3):1232-43. PubMed ID: 19124247
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.
Chiba J; Iimura S; Yoneda Y; Watanabe T; Muro F; Tsubokawa M; Iigou Y; Satoh A; Takayama G; Yokoyama M; Takashi T; Nakayama A; Machinaga N
Bioorg Med Chem; 2007 Feb; 15(4):1679-93. PubMed ID: 17194595
[TBL] [Abstract][Full Text] [Related]
4. Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.
Lin LS; Lanza TJ; Castonguay LA; Kamenecka T; McCauley E; Van Riper G; Egger LA; Mumford RA; Tong X; MacCoss M; Schmidt JA; Hagmann WK
Bioorg Med Chem Lett; 2004 May; 14(9):2331-4. PubMed ID: 15081035
[TBL] [Abstract][Full Text] [Related]
5. Imidazopyridines as VLA-4 integrin antagonists.
Phillips DJ; Davenport RJ; Demaude TA; Galleway FP; Jones MW; Knerr L; Perry BG; Ratcliffe AJ
Bioorg Med Chem Lett; 2008 Jul; 18(14):4146-9. PubMed ID: 18539454
[TBL] [Abstract][Full Text] [Related]
6. Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.
Dyatkin AB; Gong Y; Miskowski TA; Kimball ES; Prouty SM; Fisher MC; Santulli RJ; Schneider CR; Wallace NH; Hornby PJ; Diamond C; Kinney WA; Maryanoff BE; Damiano BP; He W
Bioorg Med Chem; 2005 Dec; 13(24):6693-702. PubMed ID: 16112583
[TBL] [Abstract][Full Text] [Related]
7. Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Venkatraman S; Lebsack AD; Alves K; Gardner MF; James J; Lingham RB; Maniar S; Mumford RA; Si Q; Stock N; Treonze KM; Wang B; Zunic J; Munoz B
Bioorg Med Chem Lett; 2009 Oct; 19(19):5803-6. PubMed ID: 19713111
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Chiba J; Takayama G; Takashi T; Yokoyama M; Nakayama A; Baldwin JJ; McDonald E; Moriarty KJ; Sarko CR; Saionz KW; Swanson R; Hussain Z; Wong A; Machinaga N
Bioorg Med Chem; 2006 Apr; 14(8):2725-46. PubMed ID: 16377201
[TBL] [Abstract][Full Text] [Related]
9. Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.
Chiba J; Machinaga N; Takashi T; Ejima A; Takayama G; Yokoyama M; Nakayama A; Baldwin JJ; McDonald E; Moriarty KJ; Sarko CR; Saionz KW; Swanson R; Hussain Z; Wong A
Bioorg Med Chem Lett; 2005 Jan; 15(1):41-5. PubMed ID: 15582407
[TBL] [Abstract][Full Text] [Related]
10. N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists.
Gutteridge CE; de Laszlo SE; Kamenecka TM; McCauley E; van Riper G; Mumford RA; Kidambi U; Egger LA; Tong S; Hagmann WK
Bioorg Med Chem Lett; 2003 Mar; 13(5):885-90. PubMed ID: 12617914
[TBL] [Abstract][Full Text] [Related]
11. Pyridone derivatives as potent and selective VLA-4 integrin antagonists.
Witherington J; Bordas V; Gaiba A; Green PM; Naylor A; Parr N; Smith DG; Takle AK; Ward RW
Bioorg Med Chem Lett; 2006 Apr; 16(8):2256-9. PubMed ID: 16455247
[TBL] [Abstract][Full Text] [Related]
12. Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.
Muro F; Iimura S; Yoneda Y; Chiba J; Watanabe T; Setoguchi M; Iigou Y; Takayama G; Yokoyama M; Takashi T; Nakayama A; Machinaga N
Bioorg Med Chem; 2008 Dec; 16(23):9991-10000. PubMed ID: 18952443
[TBL] [Abstract][Full Text] [Related]
13. Constraining the amide bond in N-sulfonylated dipeptide VLA-4 antagonists.
Chang LL; Yang GX; McCauley E; Mumford RA; Schmidt JA; Hagmann WK
Bioorg Med Chem Lett; 2008 Mar; 18(5):1688-91. PubMed ID: 18242984
[TBL] [Abstract][Full Text] [Related]
14. Synthetic study of VLA-4/VCAM-1 inhibitors: synthesis and structure-activity relationship of piperazinylphenylalanine derivatives.
Saku O; Ohta K; Arai E; Nomoto Y; Miura H; Nakamura H; Fuse E; Nakasato Y
Bioorg Med Chem Lett; 2008 Feb; 18(3):1053-7. PubMed ID: 18160288
[TBL] [Abstract][Full Text] [Related]
15. Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.
Witherington J; Blaney EL; Bordas V; Elliott RL; Gaiba A; Garton N; Green PM; Naylor A; Smith DG; Spalding DJ; Takle AK; Ward RW
Bioorg Med Chem Lett; 2006 Nov; 16(21):5538-41. PubMed ID: 16931004
[TBL] [Abstract][Full Text] [Related]
16. N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.
Li B; de Laszlo SE; Kamenecka TM; Kopka IE; Durette PL; Lanza T; MacCoss M; Tong S; Mumford RA; McCauley ED; Van Riper G; Schmidt JA; Hagmann WK
Bioorg Med Chem Lett; 2002 Aug; 12(16):2141-4. PubMed ID: 12127523
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists.
Rehman A; Soni A; Naik K; Nair S; Palle VP; Dastidar S; Ray A; Alam MS; Salman M; Cliffe IA; Sattigeri V
Bioorg Med Chem Lett; 2010 Sep; 20(18):5514-20. PubMed ID: 20705461
[TBL] [Abstract][Full Text] [Related]
18. 2,6-Quinolinyl derivatives as potent VLA-4 antagonists.
Lassoie MA; Broeders F; Collart P; Defrère L; de Laveleye-Defais F; Demaude T; Gassama A; Guillaumet G; Hayez JC; Kiss L; Knerr L; Nicolas JM; Norsikian S; Quéré L; Routier S; Verbois V; Provins L
Bioorg Med Chem Lett; 2007 Jan; 17(1):142-6. PubMed ID: 17035017
[TBL] [Abstract][Full Text] [Related]
19. The discovery of VLA-4 antagonists.
Tilley JW; Chen L; Sidduri A; Fotouhi N
Curr Top Med Chem; 2004; 4(14):1509-23. PubMed ID: 15544541
[TBL] [Abstract][Full Text] [Related]
20. Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.
DiMauro EF; Buchanan JL; Cheng A; Emkey R; Hitchcock SA; Huang L; Huang MY; Janosky B; Lee JH; Li X; Martin MW; Tomlinson SA; White RD; Zheng XM; Patel VF; Fremeau RT
Bioorg Med Chem Lett; 2008 Aug; 18(15):4267-74. PubMed ID: 18640038
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
