These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 16046393)

  • 1. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.
    Takahashi K; Nakagawa M; Young SG; Yamanaka S
    J Biol Chem; 2005 Sep; 280(38):32768-74. PubMed ID: 16046393
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
    Hanker AB; Mitin N; Wilder RS; Henske EP; Tamanoi F; Cox AD; Der CJ
    Oncogene; 2010 Jan; 29(3):380-91. PubMed ID: 19838215
    [TBL] [Abstract][Full Text] [Related]  

  • 3. N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.
    Cadwallader KA; Paterson H; Macdonald SG; Hancock JF
    Mol Cell Biol; 1994 Jul; 14(7):4722-30. PubMed ID: 8007974
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
    Alam H; Maizels ET; Park Y; Ghaey S; Feiger ZJ; Chandel NS; Hunzicker-Dunn M
    J Biol Chem; 2004 May; 279(19):19431-40. PubMed ID: 14982927
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.
    Nomura K; Kanemura H; Satoh T; Kataoka T
    J Biol Chem; 2004 May; 279(21):22664-73. PubMed ID: 15031297
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
    Smith EM; Finn SG; Tee AR; Browne GJ; Proud CG
    J Biol Chem; 2005 May; 280(19):18717-27. PubMed ID: 15772076
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.
    Gentry LR; Nishimura A; Cox AD; Martin TD; Tsygankov D; Nishida M; Elston TC; Der CJ
    J Biol Chem; 2015 Sep; 290(37):22851-61. PubMed ID: 26216878
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural basis for the unique biological function of small GTPase RHEB.
    Yu Y; Li S; Xu X; Li Y; Guan K; Arnold E; Ding J
    J Biol Chem; 2005 Apr; 280(17):17093-100. PubMed ID: 15728574
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.
    Yan L; Findlay GM; Jones R; Procter J; Cao Y; Lamb RF
    J Biol Chem; 2006 Jul; 281(29):19793-7. PubMed ID: 16728407
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
    Bergo MO; Ambroziak P; Gregory C; George A; Otto JC; Kim E; Nagase H; Casey PJ; Balmain A; Young SG
    Mol Cell Biol; 2002 Jan; 22(1):171-81. PubMed ID: 11739732
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Localization of Rheb to the endomembrane is critical for its signaling function.
    Buerger C; DeVries B; Stambolic V
    Biochem Biophys Res Commun; 2006 Jun; 344(3):869-80. PubMed ID: 16631613
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL; Kato-Stankiewicz J; Jiang C; Miyamoto S; Guo L; Tamanoi F
    Mol Cancer Ther; 2005 Jun; 4(6):918-26. PubMed ID: 15956249
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.
    Long X; Lin Y; Ortiz-Vega S; Busch S; Avruch J
    J Biol Chem; 2007 Jun; 282(25):18542-18551. PubMed ID: 17470430
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
    Basso AD; Mirza A; Liu G; Long BJ; Bishop WR; Kirschmeier P
    J Biol Chem; 2005 Sep; 280(35):31101-8. PubMed ID: 16006564
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.
    Clark GJ; Kinch MS; Rogers-Graham K; Sebti SM; Hamilton AD; Der CJ
    J Biol Chem; 1997 Apr; 272(16):10608-15. PubMed ID: 9099708
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane.
    Hancock JF; Paterson H; Marshall CJ
    Cell; 1990 Oct; 63(1):133-9. PubMed ID: 2208277
    [TBL] [Abstract][Full Text] [Related]  

  • 17. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.
    Apolloni A; Prior IA; Lindsay M; Parton RG; Hancock JF
    Mol Cell Biol; 2000 Apr; 20(7):2475-87. PubMed ID: 10713171
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Constitutively active Rheb induces oncogenic transformation.
    Jiang H; Vogt PK
    Oncogene; 2008 Sep; 27(43):5729-40. PubMed ID: 18521078
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases.
    Michaelson D; Ali W; Chiu VK; Bergo M; Silletti J; Wright L; Young SG; Philips M
    Mol Biol Cell; 2005 Apr; 16(4):1606-16. PubMed ID: 15659645
    [TBL] [Abstract][Full Text] [Related]  

  • 20. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
    Yamagata K; Sanders LK; Kaufmann WE; Yee W; Barnes CA; Nathans D; Worley PF
    J Biol Chem; 1994 Jun; 269(23):16333-9. PubMed ID: 8206940
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.