BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

318 related articles for article (PubMed ID: 16046402)

  • 1. Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage.
    Grujic M; Braga T; Lukinius A; Eloranta ML; Knight SD; Pejler G; Abrink M
    J Biol Chem; 2005 Sep; 280(39):33411-8. PubMed ID: 16046402
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.
    Sutton VR; Brennan AJ; Ellis S; Danne J; Thia K; Jenkins MR; Voskoboinik I; Pejler G; Johnstone RW; Andrews DM; Trapani JA
    FEBS J; 2016 Mar; 283(5):947-61. PubMed ID: 26756195
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.
    Veugelers K; Motyka B; Goping IS; Shostak I; Sawchuk T; Bleackley RC
    Mol Biol Cell; 2006 Feb; 17(2):623-33. PubMed ID: 16280358
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH.
    Masson D; Peters PJ; Geuze HJ; Borst J; Tschopp J
    Biochemistry; 1990 Dec; 29(51):11229-35. PubMed ID: 2125503
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.
    Waterhouse NJ; Sutton VR; Sedelies KA; Ciccone A; Jenkins M; Turner SJ; Bird PI; Trapani JA
    J Cell Biol; 2006 Apr; 173(1):133-44. PubMed ID: 16606695
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
    Metkar SS; Wang B; Aguilar-Santelises M; Raja SM; Uhlin-Hansen L; Podack E; Trapani JA; Froelich CJ
    Immunity; 2002 Mar; 16(3):417-28. PubMed ID: 11911826
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of CTL induction by rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity.
    Makrigiannis AP; Hoskin DW
    J Immunol; 1997 Nov; 159(10):4700-7. PubMed ID: 9366393
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.
    Browne KA; Johnstone RW; Jans DA; Trapani JA
    J Biol Chem; 2000 Dec; 275(50):39262-6. PubMed ID: 11050075
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.
    Simon MM; Hausmann M; Tran T; Ebnet K; Tschopp J; ThaHla R; Müllbacher A
    J Exp Med; 1997 Nov; 186(10):1781-6. PubMed ID: 9362539
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes.
    Sobek V; Balkow S; Körner H; Simon MM
    Eur J Immunol; 2002 Sep; 32(9):2490-9. PubMed ID: 12207333
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
    Raja SM; Metkar SS; Froelich CJ
    Curr Opin Immunol; 2003 Oct; 15(5):528-32. PubMed ID: 14499261
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
    Raja SM; Metkar SS; Höning S; Wang B; Russin WA; Pipalia NH; Menaa C; Belting M; Cao X; Dressel R; Froelich CJ
    J Biol Chem; 2005 May; 280(21):20752-61. PubMed ID: 15788411
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis.
    Veugelers K; Motyka B; Frantz C; Shostak I; Sawchuk T; Bleackley RC
    Blood; 2004 May; 103(10):3845-53. PubMed ID: 14739229
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Virally infected hepatocytes are resistant to perforin-dependent CTL effector mechanisms.
    Kafrouni MI; Brown GR; Thiele DL
    J Immunol; 2001 Aug; 167(3):1566-74. PubMed ID: 11466378
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules.
    Krähenbühl O; Gattesco S; Tschopp J
    Immunobiology; 1992 Apr; 184(4-5):392-401. PubMed ID: 1350566
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.
    Zelinskyy G; Balkow S; Schimmer S; Schepers K; Simon MM; Dittmer U
    Virology; 2004 Dec; 330(2):365-74. PubMed ID: 15567431
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin.
    Grujic M; Christensen JP; Sørensen MR; Abrink M; Pejler G; Thomsen AR
    J Immunol; 2008 Jul; 181(2):1043-51. PubMed ID: 18606656
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of perforin, granzymes and the proliferative state of the target cells in apoptosis and necrosis mediated by bispecific-antibody-activated cytotoxic T cells.
    Renner C; Held G; Ohnesorge S; Bauer S; Gerlach K; Pfitzenmeier JP; Pfreundschuh M
    Cancer Immunol Immunother; 1997 Apr; 44(2):70-6. PubMed ID: 9177467
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.
    Johnson BJ; Costelloe EO; Fitzpatrick DR; Haanen JB; Schumacher TN; Brown LE; Kelso A
    Proc Natl Acad Sci U S A; 2003 Mar; 100(5):2657-62. PubMed ID: 12601154
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
    Graubert TA; DiPersio JF; Russell JH; Ley TJ
    J Clin Invest; 1997 Aug; 100(4):904-11. PubMed ID: 9259590
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.