BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

234 related articles for article (PubMed ID: 16046533)

  • 1. Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.
    Thomas M; Gessner A; Vornlocher HP; Hadwiger P; Greil J; Heidenreich O
    Blood; 2005 Nov; 106(10):3559-66. PubMed ID: 16046533
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.
    Gessner A; Thomas M; Castro PG; Büchler L; Scholz A; Brümmendorf TH; Soria NM; Vormoor J; Greil J; Heidenreich O
    Leukemia; 2010 Oct; 24(10):1751-9. PubMed ID: 20686504
    [TBL] [Abstract][Full Text] [Related]  

  • 3. circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression.
    Huang W; Fang K; Chen TQ; Zeng ZC; Sun YM; Han C; Sun LY; Chen ZH; Yang QQ; Pan Q; Luo XQ; Wang WT; Chen YQ
    J Hematol Oncol; 2019 Oct; 12(1):103. PubMed ID: 31623653
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
    Orlovsky K; Kalinkovich A; Rozovskaia T; Shezen E; Itkin T; Alder H; Ozer HG; Carramusa L; Avigdor A; Volinia S; Buchberg A; Mazo A; Kollet O; Largman C; Croce CM; Nakamura T; Lapidot T; Canaani E
    Proc Natl Acad Sci U S A; 2011 May; 108(19):7956-61. PubMed ID: 21518888
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MiR-27a downregulates 14-3-3θ, RUNX1, AF4, and MLL-AF4, crucial drivers of blast transformation in t(4;11) leukemia cells.
    Fioretti T; Zanobio M; Raia M; Errichiello S; Izzo B; Cattaneo F; Ammendola R; Cevenini A; Esposito G
    Cell Biochem Funct; 2022 Oct; 40(7):706-717. PubMed ID: 35981137
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene.
    Dou L; Li J; Zheng D; Li Y; Gao X; Xu C; Gao L; Wang L; Yu L
    Mol Biol Rep; 2013 Dec; 40(12):6811-9. PubMed ID: 24057258
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates
    Fioretti T; Cevenini A; Zanobio M; Raia M; Sarnataro D; Cattaneo F; Ammendola R; Esposito G
    Int J Mol Sci; 2021 Apr; 22(9):. PubMed ID: 33924850
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.
    Bursen A; Schwabe K; Rüster B; Henschler R; Ruthardt M; Dingermann T; Marschalek R
    Blood; 2010 Apr; 115(17):3570-9. PubMed ID: 20194896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation.
    Fioretti T; Cevenini A; Zanobio M; Raia M; Sarnataro D; Salvatore F; Esposito G
    Cell Oncol (Dordr); 2019 Dec; 42(6):829-845. PubMed ID: 31493143
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.
    Montes R; Ayllón V; Gutierrez-Aranda I; Prat I; Hernández-Lamas MC; Ponce L; Bresolin S; Te Kronnie G; Greaves M; Bueno C; Menendez P
    Blood; 2011 May; 117(18):4746-58. PubMed ID: 21389315
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia.
    van der Linden MH; Seslija L; Schneider P; Driessen EM; Castro PG; Stumpel DJ; van Roon E; de Boer J; Williams O; Pieters R; Stam RW
    PLoS One; 2015; 10(3):e0120326. PubMed ID: 25793396
    [TBL] [Abstract][Full Text] [Related]  

  • 12. t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL.
    Kumar AR; Yao Q; Li Q; Sam TA; Kersey JH
    Leuk Res; 2011 Mar; 35(3):305-9. PubMed ID: 20869771
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice.
    Tamai H; Miyake K; Yamaguchi H; Shimada T; Dan K; Inokuchi K
    Bone Marrow Transplant; 2014 May; 49(5):699-703. PubMed ID: 24583627
    [TBL] [Abstract][Full Text] [Related]  

  • 14. FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.
    Bueno C; Ayllón V; Montes R; Navarro-Montero O; Ramos-Mejia V; Real PJ; Romero-Moya D; Araúzo-Bravo MJ; Menendez P
    Blood; 2013 May; 121(19):3867-78, S1-3. PubMed ID: 23479570
    [TBL] [Abstract][Full Text] [Related]  

  • 15. miR-130b and miR-128a are essential lineage-specific codrivers of t(4;11) MLL-AF4 acute leukemia.
    Malouf C; Antunes ETB; O'Dwyer M; Jakobczyk H; Sahm F; Landua SL; Anderson RA; Soufi A; Halsey C; Ottersbach K
    Blood; 2021 Nov; 138(21):2066-2092. PubMed ID: 34111240
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression.
    Dou L; Zheng D; Li J; Li Y; Gao L; Wang L; Yu L
    Oncogene; 2012 Jan; 31(4):507-17. PubMed ID: 21706045
    [TBL] [Abstract][Full Text] [Related]  

  • 17. MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.
    Godfrey L; Kerry J; Thorne R; Repapi E; Davies JO; Tapia M; Ballabio E; Hughes JR; Geng H; Konopleva M; Milne TA
    Exp Hematol; 2017 Mar; 47():64-75. PubMed ID: 27856324
    [TBL] [Abstract][Full Text] [Related]  

  • 18. AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice.
    Tamai H; Miyake K; Yamaguchi H; Takatori M; Dan K; Inokuchi K; Shimada T
    Blood; 2012 Jan; 119(1):64-71. PubMed ID: 22025528
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.
    Uckun FM; Herman-Hatten K; Crotty ML; Sensel MG; Sather HN; Tuel-Ahlgren L; Sarquis MB; Bostrom B; Nachman JB; Steinherz PG; Gaynon PS; Heerema N
    Blood; 1998 Aug; 92(3):810-21. PubMed ID: 9680349
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.
    Bueno C; Montes R; Catalina P; Rodríguez R; Menendez P
    Leukemia; 2011 Mar; 25(3):400-10. PubMed ID: 21135858
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.