BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 1606134)

  • 1. Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase.
    Liu L; Santi DV
    Biochemistry; 1992 Jun; 31(22):5100-4. PubMed ID: 1606134
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
    Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM
    Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel dCMP methylase by engineering thymidylate synthase.
    Agarwalla S; LaPorte S; Liu L; Finer-Moore J; Stroud RM; Santi DV
    Biochemistry; 1997 Dec; 36(50):15909-17. PubMed ID: 9398324
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
    Costi PM; Liu L; Finer-Moore JS; Stroud RM; Santi DV
    Biochemistry; 1996 Apr; 35(13):3944-9. PubMed ID: 8672425
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.
    Kealey JT; Eckstein J; Santi DV
    Chem Biol; 1995 Sep; 2(9):609-14. PubMed ID: 9383465
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis.
    Liu L; Santi DV
    Proc Natl Acad Sci U S A; 1993 Sep; 90(18):8604-8. PubMed ID: 8378336
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase.
    Liu L; Santi DV
    Biochemistry; 1993 Sep; 32(36):9263-7. PubMed ID: 8369294
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity.
    Hardy LW; Nalivaika E
    Proc Natl Acad Sci U S A; 1992 Oct; 89(20):9725-9. PubMed ID: 1409689
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
    Birdsall DL; Huang W; Santi DV; Stroud RM; Finer-Moore J
    Protein Eng; 1998 Mar; 11(3):171-83. PubMed ID: 9613841
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation.
    Carreras CW; Climie SC; Santi DV
    Biochemistry; 1992 Jul; 31(26):6038-44. PubMed ID: 1627546
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis.
    Chiericatti G; Santi DV
    Biochemistry; 1998 Jun; 37(25):9038-42. PubMed ID: 9636048
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase.
    Téllez-Sanz R; Bernier-Villamor V; García-Fuentes L; González-Pacanowska D; Barón C
    FEBS Lett; 1997 Jun; 409(3):385-90. PubMed ID: 9224695
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
    Finer-Moore JS; Liu L; Birdsall DL; Brem R; Apfeld J; Santi DV; Stroud RM
    J Mol Biol; 1998 Feb; 276(1):113-29. PubMed ID: 9514716
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Partial restoration of activity to Lactobacillus casei thymidylate synthase following inactivation by domain deletion.
    Schellenberger U; Balaram P; Francis VS; Shoichet BK; Santi DV
    Biochemistry; 1994 May; 33(18):5623-9. PubMed ID: 8180187
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
    Finer-Moore JS; Fauman EB; Morse RJ; Santi DV; Stroud RM
    Protein Eng; 1996 Jan; 9(1):69-75. PubMed ID: 9053905
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutagenesis, structure and function studies of thymidylate synthase.
    Santi DV
    Nucleic Acids Symp Ser; 1993; (29):103-5. PubMed ID: 8247725
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
    Newby Z; Lee TT; Morse RJ; Liu Y; Liu L; Venkatraman P; Santi DV; Finer-Moore JS; Stroud RM
    Biochemistry; 2006 Jun; 45(24):7415-28. PubMed ID: 16768437
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Use of a purified heterodimer to test negative cooperativity as the basis of substrate inactivation of Escherichia coli thymidylate synthase (Asn177-->Asp).
    Hardy LW; Pacitti DF; Nalivaika E
    Structure; 1994 Sep; 2(9):833-8. PubMed ID: 7812717
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis.
    Zhao G; Chen C; Xiong W; Gao T; Deng Z; Wu G; He X
    Sci Rep; 2016 Dec; 6():39675. PubMed ID: 28000775
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.