BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 16076505)

  • 1. The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices.
    Rutten K; Vente JD; Sik A; Ittersum MM; Prickaerts J; Blokland A
    Behav Brain Res; 2005 Oct; 164(1):11-6. PubMed ID: 16076505
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord.
    de Vente J; Markerink-van Ittersum M; Vles JS
    J Chem Neuroanat; 2006 Jun; 31(4):275-303. PubMed ID: 16621445
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors.
    Rutten K; Prickaerts J; Hendrix M; van der Staay FJ; Sik A; Blokland A
    Eur J Pharmacol; 2007 Mar; 558(1-3):107-12. PubMed ID: 17207788
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphodiesterase type 5 inhibition improves early memory consolidation of object information.
    Prickaerts J; Sik A; van Staveren WC; Koopmans G; Steinbusch HW; van der Staay FJ; de Vente J; Blokland A
    Neurochem Int; 2004 Nov; 45(6):915-28. PubMed ID: 15312986
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
    Blount MA; Beasley A; Zoraghi R; Sekhar KR; Bessay EP; Francis SH; Corbin JD
    Mol Pharmacol; 2004 Jul; 66(1):144-52. PubMed ID: 15213306
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sildenafil reduces cardiovascular remodeling associated with hypertensive cardiomyopathy in NOS inhibitor-treated rats.
    Ferreira-Melo SE; Yugar-Toledo JC; Coelho OR; De Luca IM; Tanus-Santos JE; Hyslop S; Irigoyen MC; Moreno H
    Eur J Pharmacol; 2006 Aug; 542(1-3):141-7. PubMed ID: 16806160
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.
    Corbin JD; Blount MA; Weeks JL; Beasley A; Kuhn KP; Ho YS; Saidi LF; Hurley JH; Kotera J; Francis SH
    Mol Pharmacol; 2003 Jun; 63(6):1364-72. PubMed ID: 12761347
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation.
    Gudmundsdóttir IJ; McRobbie SJ; Robinson SD; Newby DE; Megson IL
    Biochem Biophys Res Commun; 2005 Nov; 337(1):382-5. PubMed ID: 16185664
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
    Patil CS; Jain NK; Singh VP; Kulkarni SK
    Indian J Exp Biol; 2004 Apr; 42(4):361-7. PubMed ID: 15088685
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat.
    Prickaerts J; van Staveren WC; Sik A; Markerink-van Ittersum M; Niewöhner U; van der Staay FJ; Blokland A; de Vente J
    Neuroscience; 2002; 113(2):351-61. PubMed ID: 12127092
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle.
    Park K; Moreland RB; Goldstein I; Atala A; Traish A
    Biochem Biophys Res Commun; 1998 Aug; 249(3):612-7. PubMed ID: 9731184
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation.
    Prickaerts J; Sik A; van der Staay FJ; de Vente J; Blokland A
    Psychopharmacology (Berl); 2005 Feb; 177(4):381-90. PubMed ID: 15630588
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion.
    Sopory S; Kaur T; Visweswariah SS
    Cell Signal; 2004 Jun; 16(6):681-92. PubMed ID: 15093609
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway.
    Moreno L; Losada B; Cogolludo Al; Lodi F; Lugnier C; Villamor E; Moro M; Tamargo J; Pérez-Vizcaíno F
    Pediatr Res; 2004 Oct; 56(4):563-70. PubMed ID: 15295092
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP.
    Wang M; Urenjak J; Fedele E; Obrenovitch TP
    Biochem Pharmacol; 2004 Apr; 67(8):1619-27. PubMed ID: 15041479
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery.
    Pauvert O; Lugnier C; Keravis T; Marthan R; Rousseau E; Savineau JP
    Br J Pharmacol; 2003 Jun; 139(3):513-22. PubMed ID: 12788811
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition.
    Yuan Z; Hein TW; Rosa RH; Kuo L
    Invest Ophthalmol Vis Sci; 2008 Feb; 49(2):720-5. PubMed ID: 18235020
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5.
    Dunkern TR; Hatzelmann A
    Cell Signal; 2005 Mar; 17(3):331-9. PubMed ID: 15567064
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells.
    Wharton J; Strange JW; Møller GM; Growcott EJ; Ren X; Franklyn AP; Phillips SC; Wilkins MR
    Am J Respir Crit Care Med; 2005 Jul; 172(1):105-13. PubMed ID: 15817798
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
    Blount MA; Zoraghi R; Ke H; Bessay EP; Corbin JD; Francis SH
    Mol Pharmacol; 2006 Nov; 70(5):1822-31. PubMed ID: 16926278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.