129 related articles for article (PubMed ID: 16078833)
1. 6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.
Chordia MD; Zigler M; Murphree LJ; Figler H; Macdonald TL; Olsson RA; Linden J
J Med Chem; 2005 Aug; 48(16):5131-9. PubMed ID: 16078833
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.
Baraldi PG; Romagnoli R; Pavani MG; Nuñez Mdel C; Tabrizi MA; Shryock JC; Leung E; Moorman AR; Uluoglu C; Iannotta V; Merighi S; Borea PA
J Med Chem; 2003 Feb; 46(5):794-809. PubMed ID: 12593659
[TBL] [Abstract][Full Text] [Related]
3. 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.
Aurelio L; Figler H; Flynn BL; Linden J; Scammells PJ
Bioorg Med Chem; 2008 Feb; 16(3):1319-27. PubMed ID: 17980606
[TBL] [Abstract][Full Text] [Related]
4. 2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.
Lütjens H; Zickgraf A; Figler H; Linden J; Olsson RA; Scammells PJ
J Med Chem; 2003 May; 46(10):1870-7. PubMed ID: 12723950
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.
van den Nieuwendijk AM; Pietra D; Heitman L; Göblyös A; IJzerman AP
J Med Chem; 2004 Jan; 47(3):663-72. PubMed ID: 14736246
[TBL] [Abstract][Full Text] [Related]
6. The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.
Aurelio L; Christopoulos A; Flynn BL; Scammells PJ; Sexton PM; Valant C
Bioorg Med Chem Lett; 2011 Jun; 21(12):3704-7. PubMed ID: 21612922
[TBL] [Abstract][Full Text] [Related]
7. Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.
Aurelio L; Valant C; Flynn BL; Sexton PM; Christopoulos A; Scammells PJ
J Med Chem; 2009 Jul; 52(14):4543-7. PubMed ID: 19514747
[TBL] [Abstract][Full Text] [Related]
8. A1 adenosine receptor antagonists, agonists, and allosteric enhancers.
Kiesman WF; Elzein E; Zablocki J
Handb Exp Pharmacol; 2009; (193):25-58. PubMed ID: 19639278
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.
Romagnoli R; Baraldi PG; Carrion MD; Cara CL; Cruz-Lopez O; Iaconinoto MA; Preti D; Shryock JC; Moorman AR; Vincenzi F; Varani K; Andrea Borea P
J Med Chem; 2008 Sep; 51(18):5875-9. PubMed ID: 18729349
[TBL] [Abstract][Full Text] [Related]
10. Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.
Aurelio L; Valant C; Flynn BL; Sexton PM; White JM; Christopoulos A; Scammells PJ
J Med Chem; 2010 Sep; 53(18):6550-9. PubMed ID: 20806896
[TBL] [Abstract][Full Text] [Related]
11. Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.
Narlawar R; Lane JR; Doddareddy M; Lin J; Brussee J; Ijzerman AP
J Med Chem; 2010 Apr; 53(8):3028-37. PubMed ID: 20345101
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers.
Göblyös A; Santiago SN; Pietra D; Mulder-Krieger T; von Frijtag Drabbe Künzel J; Brussee J; Ijzerman AP
Bioorg Med Chem; 2005 Mar; 13(6):2079-87. PubMed ID: 15727861
[TBL] [Abstract][Full Text] [Related]
13. 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.
Chang LC; Spanjersberg RF; von Frijtag Drabbe Künzel JK; Mulder-Krieger T; van den Hout G; Beukers MW; Brussee J; Ijzerman AP
J Med Chem; 2004 Dec; 47(26):6529-40. PubMed ID: 15588088
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A₁ adenosine receptor.
Romagnoli R; Baraldi PG; Carrion MD; Cruz-Lopez O; Cara CL; Saponaro G; Preti D; Tabrizi MA; Baraldi S; Moorman AR; Vincenzi F; Borea PA; Varani K
Bioorg Med Chem; 2014 Jan; 22(1):148-66. PubMed ID: 24332652
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action.
Göblyös A; de Vries H; Brussee J; Ijzerman AP
J Med Chem; 2005 Feb; 48(4):1145-51. PubMed ID: 15715480
[TBL] [Abstract][Full Text] [Related]
16. 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.
Chang LC; Spanjersberg RF; von Frijtag Drabbe Künzel JK; Mulder-Krieger T; Brussee J; Ijzerman AP
J Med Chem; 2006 May; 49(10):2861-7. PubMed ID: 16686529
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity.
Bevan N; Butchers PR; Cousins R; Coates J; Edgar EV; Morrison V; Sheehan MJ; Reeves J; Wilson DJ
Eur J Pharmacol; 2007 Jun; 564(1-3):219-25. PubMed ID: 17382926
[TBL] [Abstract][Full Text] [Related]
18. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.
Kiesman WF; Zhao J; Conlon PR; Dowling JE; Petter RC; Lutterodt F; Jin X; Smits G; Fure M; Jayaraj A; Kim J; Sullivan G; Linden J
J Med Chem; 2006 Nov; 49(24):7119-31. PubMed ID: 17125264
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.
Baraldi PG; Pavani MG; Shryock JC; Moorman AR; Iannotta V; Borea PA; Romagnoli R
Eur J Med Chem; 2004 Oct; 39(10):855-65. PubMed ID: 15464619
[TBL] [Abstract][Full Text] [Related]
20. Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Cosimelli B; Greco G; Ehlardo M; Novellino E; Da Settimo F; Taliani S; La Motta C; Bellandi M; Tuccinardi T; Martinelli A; Ciampi O; Trincavelli ML; Martini C
J Med Chem; 2008 Mar; 51(6):1764-70. PubMed ID: 18269230
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
