465 related articles for article (PubMed ID: 16087724)
21. Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.
Frick C; Atanasov AG; Arnold P; Ozols J; Odermatt A
J Biol Chem; 2004 Jul; 279(30):31131-8. PubMed ID: 15152005
[TBL] [Abstract][Full Text] [Related]
22. Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1.
Meyer A; Vuorinen A; Zielinska AE; Da Cunha T; Strajhar P; Lavery GG; Schuster D; Odermatt A
Biochem Pharmacol; 2013 May; 85(9):1370-8. PubMed ID: 23419873
[TBL] [Abstract][Full Text] [Related]
23. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
Julian LD; Wang Z; Bostick T; Caille S; Choi R; DeGraffenreid M; Di Y; He X; Hungate RW; Jaen JC; Liu J; Monshouwer M; McMinn D; Rew Y; Sudom A; Sun D; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
J Med Chem; 2008 Jul; 51(13):3953-60. PubMed ID: 18553955
[TBL] [Abstract][Full Text] [Related]
24. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
Shah U; Boyle CD; Chackalamannil S; Baker H; Kowalski T; Lee J; Terracina G; Zhang L
Bioorg Med Chem Lett; 2010 Mar; 20(5):1551-4. PubMed ID: 20149650
[TBL] [Abstract][Full Text] [Related]
25. Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice.
Park JS; Rhee SD; Jung WH; Kang NS; Kim HY; Kang SK; Ahn JH; Kim KY
Eur J Pharmacol; 2012 Sep; 691(1-3):19-27. PubMed ID: 22760069
[TBL] [Abstract][Full Text] [Related]
26. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
Hermanowski-Vosatka A; Balkovec JM; Cheng K; Chen HY; Hernandez M; Koo GC; Le Grand CB; Li Z; Metzger JM; Mundt SS; Noonan H; Nunes CN; Olson SH; Pikounis B; Ren N; Robertson N; Schaeffer JM; Shah K; Springer MS; Strack AM; Strowski M; Wu K; Wu T; Xiao J; Zhang BB; Wright SD; Thieringer R
J Exp Med; 2005 Aug; 202(4):517-27. PubMed ID: 16103409
[TBL] [Abstract][Full Text] [Related]
27. Effects of bile acids on rat hepatic microsomal type I 11beta-hydroxysteroid dehydrogenase.
Maeda Y; Naganuma S; Niina I; Shinohara A; Koshimoto C; Kondo K; Chijiiwa K
Steroids; 2010 Feb; 75(2):164-8. PubMed ID: 19948178
[TBL] [Abstract][Full Text] [Related]
28. 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors with oleanan and ursan scaffolds.
Blum A; Favia AD; Maser E
Mol Cell Endocrinol; 2009 Mar; 301(1-2):132-6. PubMed ID: 18822345
[TBL] [Abstract][Full Text] [Related]
29. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target.
Wamil M; Seckl JR
Drug Discov Today; 2007 Jul; 12(13-14):504-20. PubMed ID: 17631244
[TBL] [Abstract][Full Text] [Related]
30. Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Xiang J; Wan ZK; Li HQ; Ipek M; Binnun E; Nunez J; Chen L; McKew JC; Mansour TS; Xu X; Suri V; Tam M; Xing Y; Li X; Hahm S; Tobin J; Saiah E
J Med Chem; 2008 Jul; 51(14):4068-71. PubMed ID: 18578516
[TBL] [Abstract][Full Text] [Related]
31. H6PDH interacts directly with 11beta-HSD1: implications for determining the directionality of glucocorticoid catalysis.
Zhang YL; Zhong X; Gjoka Z; Li Y; Stochaj W; Stahl M; Kriz R; Tobin JF; Erbe D; Suri V
Arch Biochem Biophys; 2009 Mar; 483(1):45-54. PubMed ID: 19121282
[TBL] [Abstract][Full Text] [Related]
32. 5Alpha-androstane-3beta,7alpha,17beta-triol and 5alpha-androstane-3beta,7beta,17beta-triol as substrates for the human 11beta-hydroxysteroid dehydrogenase type 1.
Hennebert O; Le Mée S; Pernelle C; Morfin R
Steroids; 2007 Nov; 72(13):855-64. PubMed ID: 17825335
[TBL] [Abstract][Full Text] [Related]
33. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
Wan ZK; Chenail E; Xiang J; Li HQ; Ipek M; Bard J; Svenson K; Mansour TS; Xu X; Tian X; Suri V; Hahm S; Xing Y; Johnson CE; Li X; Qadri A; Panza D; Perreault M; Tobin JF; Saiah E
J Med Chem; 2009 Sep; 52(17):5449-61. PubMed ID: 19673466
[TBL] [Abstract][Full Text] [Related]
34. In vivo activity of 11β-hydroxysteroid dehydrogenase type 1 in man: effects of prednisolone and chenodesoxycholic acid.
Diederich S; Quinkler M; Mai K; Schöneshöfer M; Baehr V; Pfeiffer A; Oelkers W; Eigendorff E
Horm Metab Res; 2011 Jan; 43(1):66-71. PubMed ID: 20925019
[TBL] [Abstract][Full Text] [Related]
35. The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding.
Kim KW; Wang Z; Busby J; Tsuruda T; Chen M; Hale C; Castro VM; Svensson S; Nybo R; Xiong F; Wang M
FEBS Lett; 2007 Mar; 581(5):995-9. PubMed ID: 17306259
[TBL] [Abstract][Full Text] [Related]
36. Upregulation of adipose 11-beta-hydroxysteroid dehydrogenase type 1 expression in ovariectomized rats is due to obesity rather than lack of estrogen.
Paulsen SK; Nielsen MP; Richelsen B; Bruun JM; Flyvbjerg A; Pedersen SB
Obesity (Silver Spring); 2008 Apr; 16(4):731-5. PubMed ID: 18379559
[TBL] [Abstract][Full Text] [Related]
37. The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate.
Kim KW; Wang Z; Busby J; Tsuruda T; Chen M; Hale C; Castro VM; Svensson S; Nybo R; Xiong F; Wang M
Biochim Biophys Acta; 2006 Apr; 1764(4):824-30. PubMed ID: 16580270
[TBL] [Abstract][Full Text] [Related]
38. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy.
Wang M
Handb Exp Pharmacol; 2011; (203):127-46. PubMed ID: 21484570
[TBL] [Abstract][Full Text] [Related]
39. 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action.
Draper N; Stewart PM
J Endocrinol; 2005 Aug; 186(2):251-71. PubMed ID: 16079253
[TBL] [Abstract][Full Text] [Related]
40. 11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
Tomlinson JW
Minerva Endocrinol; 2005 Mar; 30(1):37-46. PubMed ID: 15877012
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
