BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 16095294)

  • 1. Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids.
    Hanessian S; Yun H; Hou Y; Tintelnot-Blomley M
    J Org Chem; 2005 Aug; 70(17):6746-56. PubMed ID: 16095294
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids.
    Hanessian S; Hou Y; Bayrakdarian M; Tintelnot-Blomley M
    J Org Chem; 2005 Aug; 70(17):6735-45. PubMed ID: 16095293
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.
    Kimura T; Shuto D; Hamada Y; Igawa N; Kasai S; Liu P; Hidaka K; Hamada T; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2005 Jan; 15(1):211-5. PubMed ID: 15582441
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.
    Hanessian S; Yun H; Hou Y; Yang G; Bayrakdarian M; Therrien E; Moitessier N; Roggo S; Veenstra S; Tintelnot-Blomley M; Rondeau JM; Ostermeier C; Strauss A; Ramage P; Paganetti P; Neumann U; Betschart C
    J Med Chem; 2005 Aug; 48(16):5175-90. PubMed ID: 16078837
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Highly diastereoselective synthesis of substituted pyrrolidines using a sequence of azomethine ylide cycloaddition and nucleophilic cyclization.
    Bélanger G; Darsigny V; Doré M; Lévesque F
    Org Lett; 2010 Apr; 12(7):1396-9. PubMed ID: 20192221
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.
    Vidal P; Timm D; Broughton H; Chen SH; Martín JA; Rivera-Sagredo A; McCarthy JR; Shapiro MJ; Espinosa JF
    J Med Chem; 2005 Dec; 48(24):7623-7. PubMed ID: 16302802
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1).
    Manzenrieder F; Frank AO; Huber T; Dorner-Ciossek C; Kessler H
    Bioorg Med Chem; 2007 Jun; 15(12):4136-43. PubMed ID: 17433698
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.
    Shimokawa J; Ishiwata T; Shirai K; Koshino H; Tanatani A; Nakata T; Hashimoto Y; Nagasawa K
    Chemistry; 2005 Nov; 11(23):6878-88. PubMed ID: 16161173
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.
    Nöteberg D; Schaal W; Hamelink E; Vrang L; Larhed M
    J Comb Chem; 2003; 5(4):456-64. PubMed ID: 12857114
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions.
    Liu H; Dou G; Shi D
    J Comb Chem; 2010 Mar; 12(2):292-4. PubMed ID: 20155893
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
    Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
    Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.
    Ziora Z; Kasai S; Hidaka K; Nagamine A; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1629-33. PubMed ID: 17251016
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease.
    Specker E; Böttcher J; Brass S; Heine A; Lilie H; Schoop A; Müller G; Griebenow N; Klebe G
    ChemMedChem; 2006 Jan; 1(1):106-17. PubMed ID: 16892342
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lewis acid-catalyzed conjugate addition-cyclization reactions of ethenetricarboxylates with substituted propargyl alcohols: stereoselectivity in the efficient one-pot synthesis of methylenetetrahydrofurans.
    Morikawa S; Yamazaki S; Tsukada M; Izuhara S; Morimoto T; Kakiuchi K
    J Org Chem; 2007 Aug; 72(17):6459-63. PubMed ID: 17636961
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and structural characterisation as 12-helix of the hexamer of a beta-amino acid tethered to a pyrrolidin-2-one ring.
    Menegazzo I; Fries A; Mammi S; Galeazzi R; Martelli G; Orena M; Rinaldi S
    Chem Commun (Camb); 2006 Dec; (47):4915-7. PubMed ID: 17136245
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Asymmetric synthesis of the cis- and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid.
    Bunnage ME; Davies SG; Roberts PM; Smith AD; Withey JM
    Org Biomol Chem; 2004 Oct; 2(19):2763-76. PubMed ID: 15455148
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
    Kimura T; Hamada Y; Stochaj M; Ikari H; Nagamine A; Abdel-Rahman H; Igawa N; Hidaka K; Nguyen JT; Saito K; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2006 May; 16(9):2380-6. PubMed ID: 16481167
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.
    Mateu N; Ciordia M; Delgado O; Sánchez-Roselló M; Trabanco AA; Van Gool M; Tresadern G; Pérez-Benito L; Fustero S
    Chemistry; 2015 Aug; 21(33):11719-26. PubMed ID: 26140617
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of pyrrolidine-containing sphingomimetics.
    Lee S; Lee S; Park HJ; Lee SK; Kim S
    Org Biomol Chem; 2011 Jun; 9(12):4580-6. PubMed ID: 21537513
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Highly enantioselective synthesis of gamma-nitro heteroaromatic ketones in a doubly stereocontrolled manner catalyzed by bifunctional thiourea catalysts based on dehydroabietic amine: a doubly stereocontrolled approach to pyrrolidine carboxylic acids.
    Jiang X; Zhang Y; Chan AS; Wang R
    Org Lett; 2009 Jan; 11(1):153-6. PubMed ID: 19067569
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.