150 related articles for article (PubMed ID: 16102965)
1. A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Embrey MW; Wai JS; Funk TW; Homnick CF; Perlow DS; Young SD; Vacca JP; Hazuda DJ; Felock PJ; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Wong BK; Lin JH; Leonard YM; Tsou NN; Zhuang L
Bioorg Med Chem Lett; 2005 Oct; 15(20):4550-4. PubMed ID: 16102965
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Melamed JY; Egbertson MS; Varga S; Vacca JP; Moyer G; Gabryelski L; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Hazuda DJ; Leonard Y; Jin L; Ellis JD; Young SD
Bioorg Med Chem Lett; 2008 Oct; 18(19):5307-10. PubMed ID: 18774711
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
Boros EE; Edwards CE; Foster SA; Fuji M; Fujiwara T; Garvey EP; Golden PL; Hazen RJ; Jeffrey JL; Johns BA; Kawasuji T; Kiyama R; Koble CS; Kurose N; Miller WH; Mote AL; Murai H; Sato A; Thompson JB; Woodward MC; Yoshinaga T
J Med Chem; 2009 May; 52(9):2754-61. PubMed ID: 19374386
[TBL] [Abstract][Full Text] [Related]
4. A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Guare JP; Wai JS; Gomez RP; Anthony NJ; Jolly SM; Cortes AR; Vacca JP; Felock PJ; Stillmock KA; Schleif WA; Moyer G; Gabryelski LJ; Jin L; Chen IW; Hazuda DJ; Young SD
Bioorg Med Chem Lett; 2006 Jun; 16(11):2900-4. PubMed ID: 16554152
[TBL] [Abstract][Full Text] [Related]
5. Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Wai JS; Kim B; Fisher TE; Zhuang L; Embrey MW; Williams PD; Staas DD; Culberson C; Lyle TA; Vacca JP; Hazuda DJ; Felock PJ; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Mallai R; Young SD
Bioorg Med Chem Lett; 2007 Oct; 17(20):5595-9. PubMed ID: 17822898
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Zhuang L; Wai JS; Embrey MW; Fisher TE; Egbertson MS; Payne LS; Guare JP; Vacca JP; Hazuda DJ; Felock PJ; Wolfe AL; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Leonard YM; Lynch JJ; Michelson SR; Young SD
J Med Chem; 2003 Feb; 46(4):453-6. PubMed ID: 12570367
[TBL] [Abstract][Full Text] [Related]
7. Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
Pace P; Di Francesco ME; Gardelli C; Harper S; Muraglia E; Nizi E; Orvieto F; Petrocchi A; Poma M; Rowley M; Scarpelli R; Laufer R; Gonzalez Paz O; Monteagudo E; Bonelli F; Hazuda D; Stillmock KA; Summa V
J Med Chem; 2007 May; 50(9):2225-39. PubMed ID: 17428043
[TBL] [Abstract][Full Text] [Related]
8. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Hazuda DJ; Anthony NJ; Gomez RP; Jolly SM; Wai JS; Zhuang L; Fisher TE; Embrey M; Guare JP; Egbertson MS; Vacca JP; Huff JR; Felock PJ; Witmer MV; Stillmock KA; Danovich R; Grobler J; Miller MD; Espeseth AS; Jin L; Chen IW; Lin JH; Kassahun K; Ellis JD; Wong BK; Xu W; Pearson PG; Schleif WA; Cortese R; Emini E; Summa V; Holloway MK; Young SD
Proc Natl Acad Sci U S A; 2004 Aug; 101(31):11233-8. PubMed ID: 15277684
[TBL] [Abstract][Full Text] [Related]
9. 4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
Summa V; Petrocchi A; Matassa VG; Gardelli C; Muraglia E; Rowley M; Paz OG; Laufer R; Monteagudo E; Pace P
J Med Chem; 2006 Nov; 49(23):6646-9. PubMed ID: 17154493
[TBL] [Abstract][Full Text] [Related]
10. Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
Gardelli C; Nizi E; Muraglia E; Crescenzi B; Ferrara M; Orvieto F; Pace P; Pescatore G; Poma M; Ferreira Mdel R; Scarpelli R; Homnick CF; Ikemoto N; Alfieri A; Verdirame M; Bonelli F; Paz OG; Taliani M; Monteagudo E; Pesci S; Laufer R; Felock P; Stillmock KA; Hazuda D; Rowley M; Summa V
J Med Chem; 2007 Oct; 50(20):4953-75. PubMed ID: 17824681
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Johnson TW; Tanis SP; Butler SL; Dalvie D; Delisle DM; Dress KR; Flahive EJ; Hu Q; Kuehler JE; Kuki A; Liu W; McClellan GA; Peng Q; Plewe MB; Richardson PF; Smith GL; Solowiej J; Tran KT; Wang H; Yu X; Zhang J; Zhu H
J Med Chem; 2011 May; 54(9):3393-417. PubMed ID: 21446745
[TBL] [Abstract][Full Text] [Related]
12. A potent and orally active HIV-1 integrase inhibitor.
Egbertson MS; Moritz HM; Melamed JY; Han W; Perlow DS; Kuo MS; Embrey M; Vacca JP; Zrada MM; Cortes AR; Wallace A; Leonard Y; Hazuda DJ; Miller MD; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Gabryelski LJ; Moyer G; Ellis JD; Jin L; Xu W; Braun MP; Kassahun K; Tsou NN; Young SD
Bioorg Med Chem Lett; 2007 Mar; 17(5):1392-8. PubMed ID: 17194584
[TBL] [Abstract][Full Text] [Related]
13. 6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
Nagasawa JY; Song J; Chen H; Kim HW; Blazel J; Ouk S; Groschel B; Borges V; Ong V; Yeh LT; Girardet JL; Vernier JM; Raney AK; Pinkerton AB
Bioorg Med Chem Lett; 2011 Jan; 21(2):760-3. PubMed ID: 21185178
[TBL] [Abstract][Full Text] [Related]
14. 5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
Peese KM; Allard CW; Connolly T; Johnson BL; Li C; Patel M; Sorensen ME; Walker MA; Meanwell NA; McAuliffe B; Minassian B; Krystal M; Parker DD; Lewis HA; Kish K; Zhang P; Nolte RT; Simmermacher J; Jenkins S; Cianci C; Naidu BN
J Med Chem; 2019 Feb; 62(3):1348-1361. PubMed ID: 30609350
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Langford HM; Williams PD; Homnick CF; Vacca JP; Felock PJ; Stillmock KA; Witmer MV; Hazuda DJ; Gabryelski LJ; Schleif WA
Bioorg Med Chem Lett; 2008 Jan; 18(2):721-5. PubMed ID: 18078751
[TBL] [Abstract][Full Text] [Related]
16. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Zeng LF; Wang Y; Kazemi R; Xu S; Xu ZL; Sanchez TW; Yang LM; Debnath B; Odde S; Xie H; Zheng YT; Ding J; Neamati N; Long YQ
J Med Chem; 2012 Nov; 55(22):9492-509. PubMed ID: 23098137
[TBL] [Abstract][Full Text] [Related]
17. 8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Fisher TE; Kim B; Staas DD; Lyle TA; Young SD; Vacca JP; Zrada MM; Hazuda DJ; Felock PJ; Schleif WA; Gabryelski LJ; Anari MR; Kochansky CJ; Wai JS
Bioorg Med Chem Lett; 2007 Dec; 17(23):6511-5. PubMed ID: 17931865
[TBL] [Abstract][Full Text] [Related]
18. The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP; Johns BA; Gartland MJ; Foster SA; Miller WH; Ferris RG; Hazen RJ; Underwood MR; Boros EE; Thompson JB; Weatherhead JG; Koble CS; Allen SH; Schaller LT; Sherrill RG; Yoshinaga T; Kobayashi M; Wakasa-Morimoto C; Miki S; Nakahara K; Noshi T; Sato A; Fujiwara T
Antimicrob Agents Chemother; 2008 Mar; 52(3):901-8. PubMed ID: 18160521
[TBL] [Abstract][Full Text] [Related]
19. The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Johns BA; Weatherhead JG; Allen SH; Thompson JB; Garvey EP; Foster SA; Jeffrey JL; Miller WH
Bioorg Med Chem Lett; 2009 Mar; 19(6):1802-6. PubMed ID: 19217781
[TBL] [Abstract][Full Text] [Related]
20. QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors.
Ravichandran V; Shalini S; Sundram K; Sokkalingam AD
Eur J Med Chem; 2010 Jul; 45(7):2791-7. PubMed ID: 20347187
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
