170 related articles for article (PubMed ID: 16114893)
1. An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.
Kornacker MG; Lai Z; Witmer M; Ma J; Hendrick J; Lee VG; Riexinger DJ; Mapelli C; Metzler W; Copeland RA
Biochemistry; 2005 Aug; 44(34):11567-73. PubMed ID: 16114893
[TBL] [Abstract][Full Text] [Related]
2. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
Sauder JM; Arthur JW; Dunbrack RL
J Mol Biol; 2000 Jul; 300(2):241-8. PubMed ID: 10873463
[TBL] [Abstract][Full Text] [Related]
3. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
Tanahashi H; Tabira T
Neurosci Lett; 2007 Nov; 428(2-3):103-8. PubMed ID: 17961921
[TBL] [Abstract][Full Text] [Related]
4. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
[TBL] [Abstract][Full Text] [Related]
5. Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
Nawrot B
Acta Biochim Pol; 2004; 51(2):431-44. PubMed ID: 15218540
[TBL] [Abstract][Full Text] [Related]
6. Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
Mancini F; Naldi M; Cavrini V; Andrisano V
J Chromatogr A; 2007 Dec; 1175(2):217-26. PubMed ID: 17991476
[TBL] [Abstract][Full Text] [Related]
7. Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.
Parsons RB; Austen BM
Biochem Soc Trans; 2007 Nov; 35(Pt 5):974-9. PubMed ID: 17956258
[TBL] [Abstract][Full Text] [Related]
8. Progress toward the discovery and development of efficacious BACE inhibitors.
Durham TB; Shepherd TA
Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
[TBL] [Abstract][Full Text] [Related]
9. Evidence for dimeric BACE-mediated APP processing.
Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Fälting J; Berg S; Lundkvist J; Lendahl U
Biochem Biophys Res Commun; 2010 Feb; 393(1):21-7. PubMed ID: 20097169
[TBL] [Abstract][Full Text] [Related]
10. Expression, purification and activity measurement of soluble BACE protein in E.coli.
Wei XC; Li H; Ji JG; Li R; Ren YF; Feng JH; Hao FY
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai); 2002 Jul; 34(4):498-501. PubMed ID: 12098775
[TBL] [Abstract][Full Text] [Related]
11. Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
Saric A; Brügge Lz; Müller-Pompalla D; Rysiok T; Ousson S; Permanne B; Quattropani A; Busch M; Beher D; Hussain I
J Biomol Screen; 2013 Mar; 18(3):277-85. PubMed ID: 23023105
[TBL] [Abstract][Full Text] [Related]
12. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
[TBL] [Abstract][Full Text] [Related]
13. Tyramine fragment binding to BACE-1.
Kuglstatter A; Stahl M; Peters JU; Huber W; Stihle M; Schlatter D; Benz J; Ruf A; Roth D; Enderle T; Hennig M
Bioorg Med Chem Lett; 2008 Feb; 18(4):1304-7. PubMed ID: 18226904
[TBL] [Abstract][Full Text] [Related]
14. Design and development of BACE-1 inhibitors.
Cumming JN; Iserloh U; Kennedy ME
Curr Opin Drug Discov Devel; 2004 Jul; 7(4):536-56. PubMed ID: 15338962
[TBL] [Abstract][Full Text] [Related]
15. Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Yang W; Fucini RV; Fahr BT; Randal M; Lind KE; Lam MB; Lu W; Lu Y; Cary DR; Romanowski MJ; Colussi D; Pietrak B; Allison TJ; Munshi SK; Penny DM; Pham P; Sun J; Thomas AE; Wilkinson JM; Jacobs JW; McDowell RS; Ballinger MD
Biochemistry; 2009 Jun; 48(21):4488-96. PubMed ID: 19284778
[TBL] [Abstract][Full Text] [Related]
16. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Baxter EW; Conway KA; Kennis L; Bischoff F; Mercken MH; Winter HL; Reynolds CH; Tounge BA; Luo C; Scott MK; Huang Y; Braeken M; Pieters SM; Berthelot DJ; Masure S; Bruinzeel WD; Jordan AD; Parker MH; Boyd RE; Qu J; Alexander RS; Brenneman DE; Reitz AB
J Med Chem; 2007 Sep; 50(18):4261-4. PubMed ID: 17685503
[TBL] [Abstract][Full Text] [Related]
17. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
Pietrak BL; Crouthamel MC; Tugusheva K; Lineberger JE; Xu M; DiMuzio JM; Steele T; Espeseth AS; Stachel SJ; Coburn CA; Graham SL; Vacca JP; Shi XP; Simon AJ; Hazuda DJ; Lai MT
Anal Biochem; 2005 Jul; 342(1):144-51. PubMed ID: 15958191
[TBL] [Abstract][Full Text] [Related]
18. BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
Evin G; Barakat A; Masters CL
Int J Biochem Cell Biol; 2010 Dec; 42(12):1923-6. PubMed ID: 20817005
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
[TBL] [Abstract][Full Text] [Related]
20. Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.
Kopcho LM; Ma J; Marcinkeviciene J; Lai Z; Witmer MR; Cheng J; Yanchunas J; Tredup J; Corbett M; Calambur D; Wittekind M; Paruchuri M; Kothari D; Lee G; Ganguly S; Ramamurthy V; Morin PE; Camac DM; King RW; Lasut AL; Ross OH; Hillman MC; Fish B; Shen K; Dowling RL; Kim YB; Graciani NR; Collins D; Combs AP; George H; Thompson LA; Copeland RA
Arch Biochem Biophys; 2003 Feb; 410(2):307-16. PubMed ID: 12573291
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
