BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 16128566)

  • 1. Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation.
    Monien BH; Krishnasamy C; Olson ST; Desai UR
    Biochemistry; 2005 Sep; 44(35):11660-8. PubMed ID: 16128566
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The role of Arg46 and Arg47 of antithrombin in heparin binding.
    Arocas V; Bock SC; Olson ST; Björk I
    Biochemistry; 1999 Aug; 38(31):10196-204. PubMed ID: 10433728
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.
    Schedin-Weiss S; Desai UR; Bock SC; Olson ST; Björk I
    Biochemistry; 2004 Jan; 43(3):675-83. PubMed ID: 14730971
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites.
    Desai UR; Petitou M; Björk I; Olson ST
    Biochemistry; 1998 Sep; 37(37):13033-41. PubMed ID: 9737884
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation.
    Chuang YJ; Swanson R; Raja SM; Bock SC; Olson ST
    Biochemistry; 2001 Jun; 40(22):6670-9. PubMed ID: 11380262
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability.
    Quinsey NS; Fitton HL; Coughlin P; Whisstock JC; Dafforn TR; Carrell RW; Bottomley SP; Pike RN
    Biochemistry; 2003 Sep; 42(34):10169-73. PubMed ID: 12939144
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change.
    Turk B; Brieditis I; Bock SC; Olson ST; Björk I
    Biochemistry; 1997 Jun; 36(22):6682-91. PubMed ID: 9184148
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin.
    Rezaie AR; Yang L; Manithody C
    Biochemistry; 2004 Mar; 43(10):2898-905. PubMed ID: 15005625
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation.
    Richard B; Swanson R; Olson ST
    J Biol Chem; 2009 Oct; 284(40):27054-64. PubMed ID: 19661062
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding.
    Arocas V; Bock SC; Raja S; Olson ST; Bjork I
    J Biol Chem; 2001 Nov; 276(47):43809-17. PubMed ID: 11567021
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Importance of lysine 125 for heparin binding and activation of antithrombin.
    Schedin-Weiss S; Desai UR; Bock SC; Gettins PG; Olson ST; Björk I
    Biochemistry; 2002 Apr; 41(15):4779-88. PubMed ID: 11939772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin.
    Huntington JA; Gettins PG
    Biochemistry; 1998 Mar; 37(10):3272-7. PubMed ID: 9521646
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
    Dementiev A; Petitou M; Herbert JM; Gettins PG
    Nat Struct Mol Biol; 2004 Sep; 11(9):863-7. PubMed ID: 15311268
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Insights into the induced fit mechanism in antithrombin-heparin interaction using molecular dynamics simulations.
    Verli H; Guimarães JA
    J Mol Graph Model; 2005 Dec; 24(3):203-12. PubMed ID: 16146701
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.
    Whisstock JC; Pike RN; Jin L; Skinner R; Pei XY; Carrell RW; Lesk AM
    J Mol Biol; 2000 Sep; 301(5):1287-305. PubMed ID: 10966821
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of arginine 129 in heparin binding and activation of antithrombin.
    Desai U; Swanson R; Bock SC; Bjork I; Olson ST
    J Biol Chem; 2000 Jun; 275(25):18976-84. PubMed ID: 10764763
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes.
    Schedin-Weiss S; Richard B; Olson ST
    Arch Biochem Biophys; 2010 Dec; 504(2):169-76. PubMed ID: 20816747
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of heparin with internally quenched fluorogenic peptides derived from heparin-binding consensus sequences, kallistatin and anti-thrombin III.
    Pimenta DC; Nantes IL; de Souza ES; Le Bonniec B; Ito AS; Tersariol IL; Oliveira V; Juliano MA; Juliano L
    Biochem J; 2002 Sep; 366(Pt 2):435-46. PubMed ID: 12000310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction.
    Rezaie AR
    Biochemistry; 1996 Feb; 35(6):1918-24. PubMed ID: 8639675
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement.
    Olson ST; Björk I; Sheffer R; Craig PA; Shore JD; Choay J
    J Biol Chem; 1992 Jun; 267(18):12528-38. PubMed ID: 1618758
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.