BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

245 related articles for article (PubMed ID: 16130521)

  • 21. Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.
    Jiao P; Xue W; Shen Y; Jin N; Liu H
    Mol Biosyst; 2014 Apr; 10(4):767-77. PubMed ID: 24452008
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Nucleoside analog inhibitors of hepatitis C virus replication.
    Carroll SS; Olsen DB
    Infect Disord Drug Targets; 2006 Mar; 6(1):17-29. PubMed ID: 16787301
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The discovery of finger loop inhibitors of the hepatitis C virus NS5B polymerase: status and prospects for novel HCV therapeutics.
    Beaulieu PL
    IDrugs; 2006 Jan; 9(1):39-43. PubMed ID: 16374732
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
    Beaulieu PL; Bös M; Bousquet Y; Fazal G; Gauthier J; Gillard J; Goulet S; LaPlante S; Poupart MA; Lefebvre S; McKercher G; Pellerin C; Austel V; Kukolj G
    Bioorg Med Chem Lett; 2004 Jan; 14(1):119-24. PubMed ID: 14684311
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
    Fenaux M; Eng S; Leavitt SA; Lee YJ; Mabery EM; Tian Y; Byun D; Canales E; Clarke MO; Doerffler E; Lazerwith SE; Lew W; Liu Q; Mertzman M; Morganelli P; Xu L; Ye H; Zhang J; Matles M; Murray BP; Mwangi J; Zhang J; Hashash A; Krawczyk SH; Bidgood AM; Appleby TC; Watkins WJ
    Antimicrob Agents Chemother; 2013 Feb; 57(2):804-10. PubMed ID: 23183437
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Multiple virtual screening approaches for finding new hepatitis C virus RNA-dependent RNA polymerase inhibitors: structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors.
    Elhefnawi M; ElGamacy M; Fares M
    BMC Bioinformatics; 2012; 13 Suppl 17(Suppl 17):S5. PubMed ID: 23282180
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Ligand-induced changes in hepatitis C virus NS5B polymerase structure.
    Rigat K; Wang Y; Hudyma TW; Ding M; Zheng X; Gentles RG; Beno BR; Gao M; Roberts SB
    Antiviral Res; 2010 Nov; 88(2):197-206. PubMed ID: 20813137
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
    Koch U; Narjes F
    Curr Top Med Chem; 2007; 7(13):1302-29. PubMed ID: 17627559
    [TBL] [Abstract][Full Text] [Related]  

  • 29. 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
    Nyanguile O; Pauwels F; Van den Broeck W; Boutton CW; Quirynen L; Ivens T; van der Helm L; Vandercruyssen G; Mostmans W; Delouvroy F; Dehertogh P; Cummings MD; Bonfanti JF; Simmen KA; Raboisson P
    Antimicrob Agents Chemother; 2008 Dec; 52(12):4420-31. PubMed ID: 18852280
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
    Howe AY; Cheng H; Johann S; Mullen S; Chunduru SK; Young DC; Bard J; Chopra R; Krishnamurthy G; Mansour T; O'Connell J
    Antimicrob Agents Chemother; 2008 Sep; 52(9):3327-38. PubMed ID: 18559648
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus.
    Qing J; Luo R; Wang Y; Nong J; Wu M; Shao Y; Tang R; Yu X; Yin Z; Sun Y
    Antiviral Res; 2016 Feb; 126():43-54. PubMed ID: 26724382
    [TBL] [Abstract][Full Text] [Related]  

  • 32. A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.
    Ranjith-Kumar CT; Wen Y; Baxter N; Bhardwaj K; Cheng Kao C
    PLoS One; 2011; 6(7):e22575. PubMed ID: 21799903
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.
    Legrand-Abravanel F; Henquell C; Le Guillou-Guillemette H; Balan V; Mirand A; Dubois M; Lunel-Fabiani F; Payan C; Izopet J
    Antivir Ther; 2009; 14(5):723-30. PubMed ID: 19704176
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation.
    Ryu K; Kim ND; Choi SI; Han CK; Yoon JH; No KT; Kim KH; Seong BL
    Bioorg Med Chem; 2009 Apr; 17(8):2975-82. PubMed ID: 19332375
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Allosteric inhibition of the hepatitis C virus NS5B RNA dependent RNA polymerase.
    Koch U; Narjes F
    Infect Disord Drug Targets; 2006 Mar; 6(1):31-41. PubMed ID: 16787302
    [TBL] [Abstract][Full Text] [Related]  

  • 36. In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors.
    Delang L; Vliegen I; Leyssen P; Neyts J
    J Hepatol; 2012 Jan; 56(1):41-8. PubMed ID: 21703175
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.
    Harper S; Avolio S; Pacini B; Di Filippo M; Altamura S; Tomei L; Paonessa G; Di Marco S; Carfi A; Giuliano C; Padron J; Bonelli F; Migliaccio G; De Francesco R; Laufer R; Rowley M; Narjes F
    J Med Chem; 2005 Jul; 48(14):4547-57. PubMed ID: 15999993
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
    Le Pogam S; Kang H; Harris SF; Leveque V; Giannetti AM; Ali S; Jiang WR; Rajyaguru S; Tavares G; Oshiro C; Hendricks T; Klumpp K; Symons J; Browner MF; Cammack N; Nájera I
    J Virol; 2006 Jun; 80(12):6146-54. PubMed ID: 16731953
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
    Laporte MG; Jackson RW; Draper TL; Gaboury JA; Galie K; Herbertz T; Hussey AR; Rippin SR; Benetatos CA; Chunduru SK; Christensen JS; Coburn GA; Rizzo CJ; Rhodes G; O'Connell J; Howe AY; Mansour TS; Collett MS; Pevear DC; Young DC; Gao T; Tyrrell DL; Kneteman NM; Burns CJ; Condon SM
    ChemMedChem; 2008 Oct; 3(10):1508-15. PubMed ID: 18729128
    [No Abstract]   [Full Text] [Related]  

  • 40. Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.
    Sims KD; Lemm J; Eley T; Liu M; Berglind A; Sherman D; Lawitz E; Vutikullird AB; Tebas P; Gao M; Pasquinelli C; Grasela DM
    Antimicrob Agents Chemother; 2014 Jun; 58(6):3496-503. PubMed ID: 24733462
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.