214 related articles for article (PubMed ID: 16133793)
1. Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.
Benbrook DM; Kamelle SA; Guruswamy SB; Lightfoot SA; Rutledge TL; Gould NS; Hannafon BN; Dunn ST; Berlin KD
Invest New Drugs; 2005 Oct; 23(5):417-28. PubMed ID: 16133793
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line.
Gnanasekaran KK; Benbrook DM; Nammalwar B; Thavathiru E; Bunce RA; Berlin KD
Eur J Med Chem; 2015; 96():209-17. PubMed ID: 25880346
[TBL] [Abstract][Full Text] [Related]
3. CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.
Lin YD; Chen S; Yue P; Zou W; Benbrook DM; Liu S; Le TC; Berlin KD; Khuri FR; Sun SY
Cancer Res; 2008 Jul; 68(13):5335-44. PubMed ID: 18593935
[TBL] [Abstract][Full Text] [Related]
4. Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.
Zacheis D; Dhar A; Lu S; Madler MM; Klucik J; Brown CW; Liu S; Clement F; Subramanian S; Weerasekare GM; Berlin KD; Gold MA; Houck JR; Fountain KR; Benbrook DM
J Med Chem; 1999 Oct; 42(21):4434-45. PubMed ID: 10543887
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780.
Nammalwar B; Bunce RA; Berlin KD; Benbrook DM; Toal C
Eur J Med Chem; 2019 May; 170():16-27. PubMed ID: 30878829
[TBL] [Abstract][Full Text] [Related]
6. Differential regulation of human ectocervical epithelial cell line proliferation and differentiation by retinoid X receptor- and retinoic acid receptor-specific retinoids.
Agarwal C; Chandraratna RA; Teng M; Nagpal S; Rorke EA; Eckert RL
Cell Growth Differ; 1996 Apr; 7(4):521-30. PubMed ID: 9052993
[TBL] [Abstract][Full Text] [Related]
7. Development of flexible-heteroarotinoids for kidney cancer.
Liu T; Masamha CP; Chengedza S; Berlin KD; Lightfoot S; He F; Benbrook DM
Mol Cancer Ther; 2009 May; 8(5):1227-38. PubMed ID: 19417155
[TBL] [Abstract][Full Text] [Related]
8. Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.
Gnanasekaran KK; Pouland T; Bunce RA; Darrell Berlin K; Abuskhuna S; Bhandari D; Mashayekhi M; Zhou DH; Benbrook DM
Bioorg Med Chem; 2020 Jan; 28(1):115244. PubMed ID: 31831296
[TBL] [Abstract][Full Text] [Related]
9. The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.
Chun KH; Benbrook DM; Berlin KD; Hong WK; Lotan R
Cancer Res; 2003 Jul; 63(13):3826-32. PubMed ID: 12839980
[TBL] [Abstract][Full Text] [Related]
10. Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo.
Myers T; Chengedza S; Lightfoot S; Pan Y; Dedmond D; Cole L; Tang Y; Benbrook DM
Invest New Drugs; 2009 Aug; 27(4):304-18. PubMed ID: 18802666
[TBL] [Abstract][Full Text] [Related]
11. Regulation of retinoid-induced differentiation in embryonal carcinoma PCC4.aza1R cells: effects of retinoid-receptor selective ligands.
Mills KJ; Vollberg TM; Nervi C; Grippo JF; Dawson MI; Jetten AM
Cell Growth Differ; 1996 Mar; 7(3):327-37. PubMed ID: 8838863
[TBL] [Abstract][Full Text] [Related]
12. Activation of retinoic acid receptor alpha is sufficient for full induction of retinoid responses in SK-BR-3 and T47D human breast cancer cells.
Schneider SM; Offterdinger M; Huber H; Grunt TW
Cancer Res; 2000 Oct; 60(19):5479-87. PubMed ID: 11034091
[TBL] [Abstract][Full Text] [Related]
13. Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2.
Watts FM; Pouland T; Bunce RA; Berlin KD; Benbrook DM; Mashayekhi M; Bhandari D; Zhou D
Eur J Med Chem; 2018 Oct; 158():720-732. PubMed ID: 30245396
[TBL] [Abstract][Full Text] [Related]
14. Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
Muccio DD; Brouillette WJ; Alam M; Vaezi MF; Sani BP; Venepally P; Reddy L; Li E; Norris AW; Simpson-Herren L; Hill DL
J Med Chem; 1996 Sep; 39(19):3625-35. PubMed ID: 8809153
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids.
Dhar A; Liu S; Klucik J; Berlin KD; Madler MM; Lu S; Ivey RT; Zacheis D; Brown CW; Nelson EC; Birckbichler PJ; Benbrook DM
J Med Chem; 1999 Sep; 42(18):3602-14. PubMed ID: 10479291
[TBL] [Abstract][Full Text] [Related]
16. Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid.
Wu S; Zhang D; Zhang ZP; Soprano DR; Soprano KJ
Oncogene; 1998 Dec; 17(22):2839-49. PubMed ID: 9879990
[TBL] [Abstract][Full Text] [Related]
17. Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells.
Liu S; Brown CW; Berlin KD; Dhar A; Guruswamy S; Brown D; Gardner GJ; Birrer MJ; Benbrook DM
J Med Chem; 2004 Feb; 47(4):999-1007. PubMed ID: 14761202
[TBL] [Abstract][Full Text] [Related]
18. Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells.
Ginn E; Baek J; Zou H; Fallatah MMJ; Liu S; Sevigny MB; Louie M
Eur J Pharmacol; 2019 Nov; 862():172634. PubMed ID: 31494077
[TBL] [Abstract][Full Text] [Related]
19. Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.
Sun SY; Yue P; Mao L; Dawson MI; Shroot B; Lamph WW; Heyman RA; Chandraratna RA; Shudo K; Hong WK; Lotan R
Clin Cancer Res; 2000 Apr; 6(4):1563-73. PubMed ID: 10778990
[TBL] [Abstract][Full Text] [Related]
20. Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma.
Guruswamy S; Lightfoot S; Gold MA; Hassan R; Berlin KD; Ivey RT; Benbrook DM
J Natl Cancer Inst; 2001 Apr; 93(7):516-25. PubMed ID: 11287445
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
