199 related articles for article (PubMed ID: 16134944)
1. Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Elsner J; Boeckler F; Heinemann FW; Hübner H; Gmeiner P
J Med Chem; 2005 Sep; 48(18):5771-9. PubMed ID: 16134944
[TBL] [Abstract][Full Text] [Related]
2. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
Grundt P; Carlson EE; Cao J; Bennett CJ; McElveen E; Taylor M; Luedtke RR; Newman AH
J Med Chem; 2005 Feb; 48(3):839-48. PubMed ID: 15689168
[TBL] [Abstract][Full Text] [Related]
3. CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.
Boeckler F; Ohnmacht U; Lehmann T; Utz W; Hübner H; Gmeiner P
J Med Chem; 2005 Apr; 48(7):2493-508. PubMed ID: 15801839
[TBL] [Abstract][Full Text] [Related]
4. N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.
Hackling A; Ghosh R; Perachon S; Mann A; Höltje HD; Wermuth CG; Schwartz JC; Sippl W; Sokoloff P; Stark H
J Med Chem; 2003 Aug; 46(18):3883-99. PubMed ID: 12930150
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors.
Dutta AK; Venkataraman SK; Fei XS; Kolhatkar R; Zhang S; Reith ME
Bioorg Med Chem; 2004 Aug; 12(16):4361-73. PubMed ID: 15265488
[TBL] [Abstract][Full Text] [Related]
6. Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.
Tuccinardi T; Schenone S; Bondavalli F; Brullo C; Bruno O; Mosti L; Zizzari AT; Tintori C; Manetti F; Ciampi O; Trincavelli ML; Martini C; Martinelli A; Botta M
ChemMedChem; 2008 Jun; 3(6):898-913. PubMed ID: 18338422
[TBL] [Abstract][Full Text] [Related]
7. Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist.
Lenz C; Haubmann C; Hübner H; Boeckler F; Gmeiner P
Bioorg Med Chem; 2005 Jan; 13(1):185-91. PubMed ID: 15582463
[TBL] [Abstract][Full Text] [Related]
8. Antiparkinson concentrations of pramipexole and PHNO occupy dopamine D2(high) and D3(high) receptors.
Seeman P; Ko F; Willeit M; McCormick P; Ginovart N
Synapse; 2005 Nov; 58(2):122-8. PubMed ID: 16088951
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).
van Vliet LA; Rodenhuis N; Dijkstra D; Wikström H; Pugsley TA; Serpa KA; Meltzer LT; Heffner TG; Wise LD; Lajiness ME; Huff RM; Svensson K; Sundell S; Lundmark M
J Med Chem; 2000 Jul; 43(15):2871-82. PubMed ID: 10956195
[TBL] [Abstract][Full Text] [Related]
10. High affinity binding for pramipexole, a dopamine D3 receptor ligand, in rat striatum.
Piercey MF; Walker EL; Feldpausch DL; Camacho-Ochoa M
Neurosci Lett; 1996 Nov; 219(2):138-40. PubMed ID: 8971799
[TBL] [Abstract][Full Text] [Related]
11. 1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.
Huber D; Hübner H; Gmeiner P
J Med Chem; 2009 Nov; 52(21):6860-70. PubMed ID: 19807103
[TBL] [Abstract][Full Text] [Related]
12. Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Tschammer N; Elsner J; Goetz A; Ehrlich K; Schuster S; Ruberg M; Kühhorn J; Thompson D; Whistler J; Hübner H; Gmeiner P
J Med Chem; 2011 Apr; 54(7):2477-91. PubMed ID: 21388142
[TBL] [Abstract][Full Text] [Related]
13. [3H]Pramipexole: a selective radioligand for the high affinity dopamine D2 receptor in bovine striatal membranes.
Ohnmacht U; Tränkle C; Mohr K; Gmeiner P
Pharmazie; 1999 Apr; 54(4):294-7. PubMed ID: 10234741
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.
Blagg J; Allerton CM; Batchelor DV; Baxter AD; Burring DJ; Carr CL; Cook AS; Nichols CL; Phipps J; Sanderson VG; Verrier H; Wong S
Bioorg Med Chem Lett; 2007 Dec; 17(24):6691-6. PubMed ID: 17976986
[TBL] [Abstract][Full Text] [Related]
15. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
Glennon JC; Van Scharrenburg G; Ronken E; Hesselink MB; Reinders JH; Van Der Neut M; Long SK; Feenstra RW; McCreary AC
Synapse; 2006 Dec; 60(8):599-608. PubMed ID: 17001660
[TBL] [Abstract][Full Text] [Related]
16. Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors.
Peglion JL; Poitevin C; Mannoury La Cour C; Dupuis D; Millan MJ
Bioorg Med Chem Lett; 2009 Apr; 19(8):2133-8. PubMed ID: 19324548
[TBL] [Abstract][Full Text] [Related]
17. New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.
Mewshaw RE; Webb MB; Marquis KL; McGaughey GB; Shi X; Wasik T; Scerni R; Brennan JA; Andree TH
J Med Chem; 1999 Jun; 42(11):2007-20. PubMed ID: 10354409
[TBL] [Abstract][Full Text] [Related]
18. Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Bettinetti L; Schlotter K; Hübner H; Gmeiner P
J Med Chem; 2002 Oct; 45(21):4594-7. PubMed ID: 12361386
[TBL] [Abstract][Full Text] [Related]
19. 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms.
Grubbs RA; Lewis MM; Owens-Vance C; Gay EA; Jassen AK; Mailman RB; Nichols DE
Bioorg Med Chem; 2004 Mar; 12(6):1403-12. PubMed ID: 15018913
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.
Chen J; Collins GT; Zhang J; Yang CY; Levant B; Woods J; Wang S
J Med Chem; 2008 Oct; 51(19):5905-8. PubMed ID: 18785726
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
