551 related articles for article (PubMed ID: 16150933)
1. Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents.
Cookson JC; Dai F; Smith V; Heald RA; Laughton CA; Stevens MF; Burger AM
Mol Pharmacol; 2005 Dec; 68(6):1551-8. PubMed ID: 16150933
[TBL] [Abstract][Full Text] [Related]
2. Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C; Amodei S; D'Angelo C; Rizzo A; Benassi B; Antonelli A; Elli R; Stevens MF; D'Incalci M; Zupi G; Biroccio A
Mol Pharmacol; 2004 Nov; 66(5):1138-46. PubMed ID: 15304549
[TBL] [Abstract][Full Text] [Related]
3. Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
Gowan SM; Heald R; Stevens MF; Kelland LR
Mol Pharmacol; 2001 Nov; 60(5):981-8. PubMed ID: 11641426
[TBL] [Abstract][Full Text] [Related]
4. PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.
Salvati E; Scarsella M; Porru M; Rizzo A; Iachettini S; Tentori L; Graziani G; D'Incalci M; Stevens MF; Orlandi A; Passeri D; Gilson E; Zupi G; Leonetti C; Biroccio A
Oncogene; 2010 Nov; 29(47):6280-93. PubMed ID: 20802516
[TBL] [Abstract][Full Text] [Related]
5. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
Phatak P; Cookson JC; Dai F; Smith V; Gartenhaus RB; Stevens MF; Burger AM
Br J Cancer; 2007 Apr; 96(8):1223-33. PubMed ID: 17406367
[TBL] [Abstract][Full Text] [Related]
6. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
Moore MJ; Schultes CM; Cuesta J; Cuenca F; Gunaratnam M; Tanious FA; Wilson WD; Neidle S
J Med Chem; 2006 Jan; 49(2):582-99. PubMed ID: 16420044
[TBL] [Abstract][Full Text] [Related]
7. RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
Lagah S; Tan IL; Radhakrishnan P; Hirst RA; Ward JH; O'Callaghan C; Smith SJ; Stevens MF; Grundy RG; Rahman R
PLoS One; 2014; 9(1):e86187. PubMed ID: 24454961
[TBL] [Abstract][Full Text] [Related]
8. Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.
Izbicka E; Wheelhouse RT; Raymond E; Davidson KK; Lawrence RA; Sun D; Windle BE; Hurley LH; Von Hoff DD
Cancer Res; 1999 Feb; 59(3):639-44. PubMed ID: 9973212
[TBL] [Abstract][Full Text] [Related]
9. Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects.
Kelland LR
Eur J Cancer; 2005 May; 41(7):971-9. PubMed ID: 15862745
[TBL] [Abstract][Full Text] [Related]
10. G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
Huang FC; Chang CC; Lou PJ; Kuo IC; Chien CW; Chen CT; Shieh FY; Chang TC; Lin JJ
Mol Cancer Res; 2008 Jun; 6(6):955-64. PubMed ID: 18515756
[TBL] [Abstract][Full Text] [Related]
11. G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.
Leonetti C; Scarsella M; Riggio G; Rizzo A; Salvati E; D'Incalci M; Staszewsky L; Frapolli R; Stevens MF; Stoppacciaro A; Mottolese M; Antoniani B; Gilson E; Zupi G; Biroccio A
Clin Cancer Res; 2008 Nov; 14(22):7284-91. PubMed ID: 19010844
[TBL] [Abstract][Full Text] [Related]
12. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines.
Zhou JM; Zhu XF; Lu YJ; Deng R; Huang ZS; Mei YP; Wang Y; Huang WL; Liu ZC; Gu LQ; Zeng YX
Oncogene; 2006 Jan; 25(4):503-11. PubMed ID: 16170347
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of human telomerase enhances the effect of chemotherapeutic agents in lung cancer cells.
Misawa M; Tauchi T; Sashida G; Nakajima A; Abe K; Ohyashiki JH; Ohyashiki K
Int J Oncol; 2002 Nov; 21(5):1087-92. PubMed ID: 12370759
[TBL] [Abstract][Full Text] [Related]
14. Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase.
Gomez D; Aouali N; Renaud A; Douarre C; Shin-Ya K; Tazi J; Martinez S; Trentesaux C; Morjani H; Riou JF
Cancer Res; 2003 Oct; 63(19):6149-53. PubMed ID: 14559794
[TBL] [Abstract][Full Text] [Related]
15. Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway.
Kelland L
Clin Cancer Res; 2007 Sep; 13(17):4960-3. PubMed ID: 17785545
[TBL] [Abstract][Full Text] [Related]
16. Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
Rha SY; Izbicka E; Lawrence R; Davidson K; Sun D; Moyer MP; Roodman GD; Hurley L; Von Hoff D
Clin Cancer Res; 2000 Mar; 6(3):987-93. PubMed ID: 10741725
[TBL] [Abstract][Full Text] [Related]
17. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Burger AM; Dai F; Schultes CM; Reszka AP; Moore MJ; Double JA; Neidle S
Cancer Res; 2005 Feb; 65(4):1489-96. PubMed ID: 15735037
[TBL] [Abstract][Full Text] [Related]
18. Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells.
Binz N; Shalaby T; Rivera P; Shin-ya K; Grotzer MA
Eur J Cancer; 2005 Dec; 41(18):2873-81. PubMed ID: 16253503
[TBL] [Abstract][Full Text] [Related]
19. The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Kim MY; Gleason-Guzman M; Izbicka E; Nishioka D; Hurley LH
Cancer Res; 2003 Jun; 63(12):3247-56. PubMed ID: 12810655
[TBL] [Abstract][Full Text] [Related]
20. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Martins C; Gunaratnam M; Stuart J; Makwana V; Greciano O; Reszka AP; Kelland LR; Neidle S
Bioorg Med Chem Lett; 2007 Apr; 17(8):2293-8. PubMed ID: 17276687
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]