129 related articles for article (PubMed ID: 16153845)
1. Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.
Dropinski JF; Akiyama T; Einstein M; Habulihaz B; Doebber T; Berger JP; Meinke PT; Shi GQ
Bioorg Med Chem Lett; 2005 Nov; 15(22):5035-8. PubMed ID: 16153845
[TBL] [Abstract][Full Text] [Related]
2. Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
Shi Q; Canada EJ; Xu Y; Warshawsky AM; Etgen GJ; Broderick CL; Clutinger CK; Irwin LA; Laurila ME; Montrose-Rafizadeh C; Oldham BA; Wang M; Winneroski LL; Xie C; York JS; Yumibe NP; Zink RW; Mantlo N
Bioorg Med Chem Lett; 2007 Dec; 17(24):6744-9. PubMed ID: 18029178
[TBL] [Abstract][Full Text] [Related]
3. PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.
Kim MK; Chae YN; Kim HS; Choi SH; Son MH; Kim SH; Kim JK; Moon HS; Park SK; Shin YA; Kim JG; Lee CH; Lim JI; Shin CY
Arch Pharm Res; 2009 May; 32(5):721-7. PubMed ID: 19471887
[TBL] [Abstract][Full Text] [Related]
4. Selective PPARgamma modulators with improved pharmacological profiles.
Liu K; Black RM; Acton JJ; Mosley R; Debenham S; Abola R; Yang M; Tschirret-Guth R; Colwell L; Liu C; Wu M; Wang CF; MacNaul KL; McCann ME; Moller DE; Berger JP; Meinke PT; Jones AB; Wood HB
Bioorg Med Chem Lett; 2005 May; 15(10):2437-40. PubMed ID: 15863293
[TBL] [Abstract][Full Text] [Related]
5. Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.
Kuhn B; Hilpert H; Benz J; Binggeli A; Grether U; Humm R; Märki HP; Meyer M; Mohr P
Bioorg Med Chem Lett; 2006 Aug; 16(15):4016-20. PubMed ID: 16737814
[TBL] [Abstract][Full Text] [Related]
6. Benzoyl 2-methyl indoles as selective PPARgamma modulators.
Acton JJ; Black RM; Jones AB; Moller DE; Colwell L; Doebber TW; Macnaul KL; Berger J; Wood HB
Bioorg Med Chem Lett; 2005 Jan; 15(2):357-62. PubMed ID: 15603954
[TBL] [Abstract][Full Text] [Related]
7. A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.
Chang CH; McNamara LA; Wu MS; Muise ES; Tan Y; Wood HB; Meinke PT; Thompson JR; Doebber TW; Berger JP; McCann ME
Eur J Pharmacol; 2008 Apr; 584(1):192-201. PubMed ID: 18346728
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.
Lamotte Y; Martres P; Faucher N; Laroze A; Grillot D; Ancellin N; Saintillan Y; Beneton V; Gampe RT
Bioorg Med Chem Lett; 2010 Feb; 20(4):1399-404. PubMed ID: 20079636
[TBL] [Abstract][Full Text] [Related]
9. Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Debenham SD; Chan A; Lau FW; Liu W; Wood HB; Lemme K; Colwell L; Habulihaz B; Akiyama TE; Einstein M; Doebber TW; Sharma N; Wang CF; Wu M; Berger JP; Meinke PT
Bioorg Med Chem Lett; 2008 Sep; 18(17):4798-801. PubMed ID: 18701276
[TBL] [Abstract][Full Text] [Related]
10. Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).
Dong X; Zhang Z; Wen R; Shen J; Shen X; Jiang H
Bioorg Med Chem Lett; 2006 Nov; 16(22):5913-6. PubMed ID: 17010604
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists.
Gim HJ; Cheon YJ; Ryu JH; Jeon R
Bioorg Med Chem Lett; 2011 May; 21(10):3057-61. PubMed ID: 21482466
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
Suh YG; Kim NJ; Koo BW; Lee KO; Moon SH; Shin DH; Jung JW; Paek SM; Chang DJ; Li F; Kang HJ; Le TV; Chae YN; Shin CY; Kim MK; Lim JI; Ryu JS; Park HJ
J Med Chem; 2008 Oct; 51(20):6318-33. PubMed ID: 18826205
[TBL] [Abstract][Full Text] [Related]
13. Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.
Liu W; Liu K; Wood HB; McCann ME; Doebber TW; Chang CH; Akiyama TE; Einstein M; Berger JP; Meinke PT
J Med Chem; 2009 Jul; 52(14):4443-53. PubMed ID: 19530681
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Zhang H; Ryono DE; Devasthale P; Wang W; O'Malley K; Farrelly D; Gu L; Harrity T; Cap M; Chu C; Locke K; Zhang L; Lippy J; Kunselman L; Morgan N; Flynn N; Moore L; Hosagrahara V; Zhang L; Kadiyala P; Xu C; Doweyko AM; Bell A; Chang C; Muckelbauer J; Zahler R; Hariharan N; Cheng PT
Bioorg Med Chem Lett; 2009 Mar; 19(5):1451-6. PubMed ID: 19201606
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists.
Gim HJ; Li H; Lee E; Ryu JH; Jeon R
Bioorg Med Chem Lett; 2013 Jan; 23(2):513-7. PubMed ID: 23265886
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Ye XY; Li YX; Farrelly D; Flynn N; Gu L; Locke KT; Lippy J; O'Malley K; Twamley C; Zhang L; Ryono DE; Zahler R; Hariharan N; Cheng PT
Bioorg Med Chem Lett; 2008 Jun; 18(12):3545-50. PubMed ID: 18511276
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.
Kim E; Park CS; Han T; Bae MH; Chong W; Lee CH; Shin YA; Ahn BN; Kim MK; Shin CY; Son MH; Kim JK; Moon HS; Shim HJ; Kim EJ; Kim SH; Lim JI; Lee CH
Bioorg Med Chem Lett; 2008 Sep; 18(18):4993-6. PubMed ID: 18771917
[TBL] [Abstract][Full Text] [Related]
18. Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
Humphries PS; Almaden JV; Barnum SJ; Carlson TJ; Do QQ; Fraser JD; Hess M; Kim YH; Ogilvie KM; Sun S
Bioorg Med Chem Lett; 2006 Dec; 16(23):6116-9. PubMed ID: 16979341
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
Pingali H; Jain M; Shah S; Makadia P; Zaware P; Goel A; Patel M; Giri S; Patel H; Patel P
Bioorg Med Chem; 2008 Aug; 16(15):7117-27. PubMed ID: 18625559
[TBL] [Abstract][Full Text] [Related]
20. Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.
Blanc-Delmas E; Lebegue N; Wallez V; Leclerc V; Yous S; Carato P; Farce A; Bennejean C; Renard P; Caignard DH; Audinot-Bouchez V; Chomarat P; Boutin J; Hennuyer N; Louche K; Carmona MC; Staels B; Pénicaud L; Casteilla L; Lonchampt M; Dacquet C; Chavatte P; Berthelot P; Lesieur D
Bioorg Med Chem; 2006 Nov; 14(22):7377-91. PubMed ID: 16887353
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]