BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 16162500)

  • 1. Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
    Parra JL; Buxadé M; Proud CG
    J Biol Chem; 2005 Nov; 280(45):37623-33. PubMed ID: 16162500
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
    Scheper GC; Morrice NA; Kleijn M; Proud CG
    Mol Cell Biol; 2001 Feb; 21(3):743-54. PubMed ID: 11154262
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
    Waskiewicz AJ; Flynn A; Proud CG; Cooper JA
    EMBO J; 1997 Apr; 16(8):1909-20. PubMed ID: 9155017
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo.
    Parra-Palau JL; Scheper GC; Harper DE; Proud CG
    Biochem J; 2005 Feb; 385(Pt 3):695-702. PubMed ID: 15487973
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.
    Ueda T; Watanabe-Fukunaga R; Fukuyama H; Nagata S; Fukunaga R
    Mol Cell Biol; 2004 Aug; 24(15):6539-49. PubMed ID: 15254222
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling.
    Parra-Palau JL; Scheper GC; Wilson ML; Proud CG
    J Biol Chem; 2003 Nov; 278(45):44197-204. PubMed ID: 12949082
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.
    Basnet SK; Diab S; Schmid R; Yu M; Yang Y; Gillam TA; Teo T; Li P; Peat T; Albrecht H; Wang S
    Mol Pharmacol; 2015 Nov; 88(5):935-48. PubMed ID: 26268528
    [TBL] [Abstract][Full Text] [Related]  

  • 8. MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
    Hu SI; Katz M; Chin S; Qi X; Cruz J; Ibebunjo C; Zhao S; Chen A; Glass DJ
    Sci Signal; 2012 Feb; 5(211):ra14. PubMed ID: 22337810
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.
    Shiers S; Sahn JJ; Price TJ
    Neuroscience; 2023 Apr; 515():96-107. PubMed ID: 36764601
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
    Scheper GC; Parra JL; Wilson M; Van Kollenburg B; Vertegaal AC; Han ZG; Proud CG
    Mol Cell Biol; 2003 Aug; 23(16):5692-705. PubMed ID: 12897141
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
    Matsui Y; Yasumatsu I; Yoshida KI; Iimura S; Ikeno Y; Nawano T; Fukano H; Ubukata O; Hanzawa H; Tanzawa F; Isoyama T
    Acta Crystallogr F Struct Biol Commun; 2018 Mar; 74(Pt 3):156-160. PubMed ID: 29497019
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.
    Dolniak B; Katsoulidis E; Carayol N; Altman JK; Redig AJ; Tallman MS; Ueda T; Watanabe-Fukunaga R; Fukunaga R; Platanias LC
    J Biol Chem; 2008 May; 283(18):12034-42. PubMed ID: 18299328
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
    Shveygert M; Kaiser C; Bradrick SS; Gromeier M
    Mol Cell Biol; 2010 Nov; 30(21):5160-7. PubMed ID: 20823271
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
    Korneeva NL; Song A; Gram H; Edens MA; Rhoads RE
    J Biol Chem; 2016 Feb; 291(7):3455-67. PubMed ID: 26668315
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity.
    Goto S; Yao Z; Proud CG
    Biochem J; 2009 Sep; 423(2):279-90. PubMed ID: 19650764
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
    Jauch R; Jäkel S; Netter C; Schreiter K; Aicher B; Jäckle H; Wahl MC
    Structure; 2005 Oct; 13(10):1559-68. PubMed ID: 16216586
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.
    Kannan S; Poulsen A; Yang HY; Ho M; Ang SH; Eldwin TS; Jeyaraj DA; Chennamaneni LR; Liu B; Hill J; Verma CS; Nacro K
    Biochemistry; 2015 Jan; 54(1):32-46. PubMed ID: 25431995
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis.
    Xie J; Shen K; Jones AT; Yang J; Tee AR; Shen MH; Yu M; Irani S; Wong D; Merrett JE; Lenchine RV; De Poi S; Jensen KB; Trim PJ; Snel MF; Kamei M; Martin SK; Fitter S; Tian S; Wang X; Butler LM; Zannettino ACW; Proud CG
    Cell Mol Life Sci; 2021 Jan; 78(1):249-270. PubMed ID: 32170339
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
    Orton KC; Ling J; Waskiewicz AJ; Cooper JA; Merrick WC; Korneeva NL; Rhoads RE; Sonenberg N; Traugh JA
    J Biol Chem; 2004 Sep; 279(37):38649-57. PubMed ID: 15234964
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors.
    Dreas A; Mikulski M; Milik M; Fabritius CH; Brzózka K; Rzymski T
    Curr Med Chem; 2017; 24(28):3025-3053. PubMed ID: 28164761
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.