BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

294 related articles for article (PubMed ID: 16169856)

  • 1. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
    Ozawa T; Araki N; Yunoue S; Tokuo H; Feng L; Patrakitkomjorn S; Hara T; Ichikawa Y; Matsumoto K; Fujii K; Saya H
    J Biol Chem; 2005 Nov; 280(47):39524-33. PubMed ID: 16169856
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.
    Vallée B; Doudeau M; Godin F; Gombault A; Tchalikian A; de Tauzia ML; Bénédetti H
    PLoS One; 2012; 7(10):e47283. PubMed ID: 23082153
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2.
    Sumi T; Matsumoto K; Takai Y; Nakamura T
    J Cell Biol; 1999 Dec; 147(7):1519-32. PubMed ID: 10613909
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta.
    Vardouli L; Moustakas A; Stournaras C
    J Biol Chem; 2005 Mar; 280(12):11448-57. PubMed ID: 15647284
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.
    Sumi T; Matsumoto K; Nakamura T
    J Biol Chem; 2001 Jan; 276(1):670-6. PubMed ID: 11018042
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.
    Patrakitkomjorn S; Kobayashi D; Morikawa T; Wilson MM; Tsubota N; Irie A; Ozawa T; Aoki M; Arimura N; Kaibuchi K; Saya H; Araki N
    J Biol Chem; 2008 Apr; 283(14):9399-413. PubMed ID: 18218617
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The pre-GAP-related domain of neurofibromin regulates cell migration through the LIM kinase/cofilin pathway.
    Starinsky-Elbaz S; Faigenbloom L; Friedman E; Stein R; Kloog Y
    Mol Cell Neurosci; 2009 Dec; 42(4):278-87. PubMed ID: 19666124
    [TBL] [Abstract][Full Text] [Related]  

  • 8. R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
    Weber SM; Brossier NM; Prechtl A; Barnes S; Wilson LS; Brosius SN; Longo JF; Carroll SL
    Cell Commun Signal; 2021 Sep; 19(1):95. PubMed ID: 34530870
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway.
    Lee S; Helfman DM
    J Biol Chem; 2004 Jan; 279(3):1885-91. PubMed ID: 14559914
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
    Maekawa M; Ishizaki T; Boku S; Watanabe N; Fujita A; Iwamatsu A; Obinata T; Ohashi K; Mizuno K; Narumiya S
    Science; 1999 Aug; 285(5429):895-8. PubMed ID: 10436159
    [TBL] [Abstract][Full Text] [Related]  

  • 11. B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization.
    Klein RM; Spofford LS; Abel EV; Ortiz A; Aplin AE
    Mol Biol Cell; 2008 Feb; 19(2):498-508. PubMed ID: 18045987
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.
    Toshima J; Toshima JY; Amano T; Yang N; Narumiya S; Mizuno K
    Mol Biol Cell; 2001 Apr; 12(4):1131-45. PubMed ID: 11294912
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1.
    Hirata Y; Brems H; Suzuki M; Kanamori M; Okada M; Morita R; Llano-Rivas I; Ose T; Messiaen L; Legius E; Yoshimura A
    J Biol Chem; 2016 Feb; 291(7):3124-34. PubMed ID: 26635368
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Multiple downstream signalling pathways from ROCK, a target molecule of Rho small G protein, in reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells.
    Takaishi K; Matozaki T; Nakano K; Takai Y
    Genes Cells; 2000 Nov; 5(11):929-936. PubMed ID: 11122380
    [TBL] [Abstract][Full Text] [Related]  

  • 15. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505.
    Amano T; Tanabe K; Eto T; Narumiya S; Mizuno K
    Biochem J; 2001 Feb; 354(Pt 1):149-59. PubMed ID: 11171090
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Neurofibromin - protein structure and cellular functions in the context of neurofibromatosis type I pathogenesis].
    Abramowicz A; Gos M
    Postepy Hig Med Dosw (Online); 2015 Dec; 69():1331-48. PubMed ID: 26671924
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
    Nebesio TD; Ming W; Chen S; Clegg T; Yuan J; Yang Y; Estwick SA; Li Y; Li X; Hingtgen CM; Yang FC
    Glia; 2007 Apr; 55(5):527-36. PubMed ID: 17236191
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.
    Thirone AC; Speight P; Zulys M; Rotstein OD; Szászi K; Pedersen SF; Kapus A
    Am J Physiol Cell Physiol; 2009 Mar; 296(3):C463-75. PubMed ID: 19109524
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes.
    Sandsmark DK; Zhang H; Hegedus B; Pelletier CL; Weber JD; Gutmann DH
    Cancer Res; 2007 May; 67(10):4790-9. PubMed ID: 17510408
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.
    Turbyville TJ; Gürsel DB; Tuskan RG; Walrath JC; Lipschultz CA; Lockett SJ; Wiemer DF; Beutler JA; Reilly KM
    Mol Cancer Ther; 2010 May; 9(5):1234-43. PubMed ID: 20442305
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.