BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 1617622)

  • 1. Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
    Chen SF; Perrella FW; Behrens DL; Papp LM
    Cancer Res; 1992 Jul; 52(13):3521-7. PubMed ID: 1617622
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationship of quinoline carboxylic acids. A new class of inhibitors of dihydroorotate dehydrogenase.
    Chen SF; Papp LM; Ardecky RJ; Rao GV; Hesson DP; Forbes M; Dexter DL
    Biochem Pharmacol; 1990 Aug; 40(4):709-14. PubMed ID: 2386542
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
    Knecht W; Henseling J; Löffler M
    Chem Biol Interact; 2000 Jan; 124(1):61-76. PubMed ID: 10658902
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differential susceptibility of dihydroorotate dehydrogenase/oxidase to Brequinar Sodium (NSC 368 390) in vitro.
    Lakaschus G; Löffler M
    Biochem Pharmacol; 1992 Mar; 43(5):1025-30. PubMed ID: 1313236
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives.
    Knecht W; Löffler M
    Biochem Pharmacol; 1998 Nov; 56(9):1259-64. PubMed ID: 9802339
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
    Peters GJ; Schwartsmann G; Nadal JC; Laurensse EJ; van Groeningen CJ; van der Vijgh WJ; Pinedo HM
    Cancer Res; 1990 Aug; 50(15):4644-9. PubMed ID: 2164443
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.
    Chen SF; Ruben RL; Dexter DL
    Cancer Res; 1986 Oct; 46(10):5014-9. PubMed ID: 3019518
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
    Hurt DE; Sutton AE; Clardy J
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1610-5. PubMed ID: 16406782
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor.
    Peters GJ
    Nucleosides Nucleotides Nucleic Acids; 2018; 37(12):666-678. PubMed ID: 30663496
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
    Cleaveland ES; Zaharevitz DW; Kelley JA; Paull K; Cooney DA; Ford H
    Biochem Biophys Res Commun; 1996 Jun; 223(3):654-9. PubMed ID: 8687451
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Histidine to alanine mutants of human dihydroorotate dehydrogenase. Identification of a brequinar-resistant mutant enzyme.
    Davis JP; Copeland RA
    Biochem Pharmacol; 1997 Aug; 54(4):459-65. PubMed ID: 9313772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
    Walse B; Dufe VT; Svensson B; Fritzson I; Dahlberg L; Khairoullina A; Wellmar U; Al-Karadaghi S
    Biochemistry; 2008 Aug; 47(34):8929-36. PubMed ID: 18672895
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase.
    Boa AN; Canavan SP; Hirst PR; Ramsey C; Stead AM; McConkey GA
    Bioorg Med Chem; 2005 Mar; 13(6):1945-67. PubMed ID: 15727850
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).
    Peters GJ; Sharma SL; Laurensse E; Pinedo HM
    Invest New Drugs; 1987; 5(3):235-44. PubMed ID: 2822596
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells.
    Knecht W; Altekruse D; Rotgeri A; Gonski S; Löffler M
    Protein Expr Purif; 1997 Jun; 10(1):89-99. PubMed ID: 9179295
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
    McLean JE; Neidhardt EA; Grossman TH; Hedstrom L
    Biochemistry; 2001 Feb; 40(7):2194-200. PubMed ID: 11329288
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans.
    Zameitat E; Gojković Z; Knecht W; Piskur J; Löffler M
    FEBS J; 2006 Jul; 273(14):3183-91. PubMed ID: 16774642
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
    Ullrich A; Knecht W; Fries M; Löffler M
    Eur J Biochem; 2001 Mar; 268(6):1861-8. PubMed ID: 11248707
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
    Bader B; Knecht W; Fries M; Löffler M
    Protein Expr Purif; 1998 Aug; 13(3):414-22. PubMed ID: 9693067
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
    He T; Haapa-Paananen S; Kaminskyy VO; Kohonen P; Fey V; Zhivotovsky B; Kallioniemi O; Perälä M
    Oncogene; 2014 Jul; 33(27):3538-49. PubMed ID: 24013224
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.