190 related articles for article (PubMed ID: 1617665)
1. Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.
Paull KD; Lin CM; Malspeis L; Hamel E
Cancer Res; 1992 Jul; 52(14):3892-900. PubMed ID: 1617665
[TBL] [Abstract][Full Text] [Related]
2. Tubulin-dependent hydrolysis of guanosine triphosphate as a screening test to identify new antitubulin compounds with potential as antimitotic agents: application to carbamates of aromatic amines.
Chi DM; Shahrik LK; Ho HH; Hamel E
Cancer Res; 1989 Mar; 49(6):1344-8. PubMed ID: 2924291
[TBL] [Abstract][Full Text] [Related]
3. Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
J Med Chem; 1997 Sep; 40(19):3049-56. PubMed ID: 9301667
[TBL] [Abstract][Full Text] [Related]
4. Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
J Med Chem; 1997 Jul; 40(14):2266-75. PubMed ID: 9216846
[TBL] [Abstract][Full Text] [Related]
5. Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.
Batra JK; Powers LJ; Hess FD; Hamel E
Cancer Res; 1986 Apr; 46(4 Pt 2):1889-93. PubMed ID: 3948171
[TBL] [Abstract][Full Text] [Related]
6. Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Prinz H; Ishii Y; Hirano T; Stoiber T; Camacho Gomez JA; Schmidt P; Düssmann H; Burger AM; Prehn JH; Günther EG; Unger E; Umezawa K
J Med Chem; 2003 Jul; 46(15):3382-94. PubMed ID: 12852768
[TBL] [Abstract][Full Text] [Related]
7. Tubulin-perturbing naphthoquinone spiroketals.
Balachandran R; Hopkins TD; Thomas CA; Wipf P; Day BW
Chem Biol Drug Des; 2008 Feb; 71(2):117-24. PubMed ID: 18194192
[TBL] [Abstract][Full Text] [Related]
8. A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.
Tahir SK; Han EK; Credo B; Jae HS; Pietenpol JA; Scatena CD; Wu-Wong JR; Frost D; Sham H; Rosenberg SH; Ng SC
Cancer Res; 2001 Jul; 61(14):5480-5. PubMed ID: 11454695
[TBL] [Abstract][Full Text] [Related]
9. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
Kuo CC; Hsieh HP; Pan WY; Chen CP; Liou JP; Lee SJ; Chang YL; Chen LT; Chen CT; Chang JY
Cancer Res; 2004 Jul; 64(13):4621-8. PubMed ID: 15231674
[TBL] [Abstract][Full Text] [Related]
10. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
Gupta K; Bishop J; Peck A; Brown J; Wilson L; Panda D
Biochemistry; 2004 Jun; 43(21):6645-55. PubMed ID: 15157098
[TBL] [Abstract][Full Text] [Related]
11. Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Ouyang X; Piatnitski EL; Pattaropong V; Chen X; He HY; Kiselyov AS; Velankar A; Kawakami J; Labelle M; Smith L; Lohman J; Lee SP; Malikzay A; Fleming J; Gerlak J; Wang Y; Rosler RL; Zhou K; Mitelman S; Camara M; Surguladze D; Doody JF; Tuma MC
Bioorg Med Chem Lett; 2006 Mar; 16(5):1191-6. PubMed ID: 16377187
[TBL] [Abstract][Full Text] [Related]
12. Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.
Batra JK; Jurd L; Hamel E
Mol Pharmacol; 1985 Jan; 27(1):94-102. PubMed ID: 3965931
[TBL] [Abstract][Full Text] [Related]
13. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Bai RL; Paull KD; Herald CL; Malspeis L; Pettit GR; Hamel E
J Biol Chem; 1991 Aug; 266(24):15882-9. PubMed ID: 1874739
[TBL] [Abstract][Full Text] [Related]
14. Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.
Kim ND; Park ES; Kim YH; Moon SK; Lee SS; Ahn SK; Yu DY; No KT; Kim KH
Bioorg Med Chem; 2010 Oct; 18(19):7092-100. PubMed ID: 20810285
[TBL] [Abstract][Full Text] [Related]
15. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.
Beckers T; Reissmann T; Schmidt M; Burger AM; Fiebig HH; Vanhoefer U; Pongratz H; Hufsky H; Hockemeyer J; Frieser M; Mahboobi S
Cancer Res; 2002 Jun; 62(11):3113-9. PubMed ID: 12036922
[TBL] [Abstract][Full Text] [Related]
16. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
Bai R; Cichacz ZA; Herald CL; Pettit GR; Hamel E
Mol Pharmacol; 1993 Oct; 44(4):757-66. PubMed ID: 8232226
[TBL] [Abstract][Full Text] [Related]
17. Structure-activity requirements for flavone cytotoxicity and binding to tubulin.
Beutler JA; Hamel E; Vlietinck AJ; Haemers A; Rajan P; Roitman JN; Cardellina JH; Boyd MR
J Med Chem; 1998 Jun; 41(13):2333-8. PubMed ID: 9632366
[TBL] [Abstract][Full Text] [Related]
18. Tricyclic pyrone analogs: a new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo.
Perchellet EM; Ladesich JB; Magill MJ; Chen Y; Hua DH; Perchellet JP
Anticancer Drugs; 1999 Jun; 10(5):489-504. PubMed ID: 10477169
[TBL] [Abstract][Full Text] [Related]
19. Biological evaluation on different human cancer cell lines of novel colchicine analogs.
De Vincenzo R; Ferlini C; Distefano M; Gaggini C; Riva A; Bombardelli E; Morazzoni P; Danieli B; Capelli G; Mancuso S; Scambia G
Oncol Res; 1999; 11(3):145-52. PubMed ID: 10527074
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Romagnoli R; Baraldi PG; Carrion MD; Cara CL; Cruz-Lopez O; Preti D; Tolomeo M; Grimaudo S; Di Cristina A; Zonta N; Balzarini J; Brancale A; Sarkar T; Hamel E
Bioorg Med Chem; 2008 May; 16(10):5367-76. PubMed ID: 18440234
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]