316 related articles for article (PubMed ID: 16181553)
1. [Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].
Liang P; Pan YX; Zhao XM; Du HZ; Zhang JM
Zhonghua Bing Li Xue Za Zhi; 2005 May; 34(5):297-301. PubMed ID: 16181553
[TBL] [Abstract][Full Text] [Related]
2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
3. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
[TBL] [Abstract][Full Text] [Related]
4. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
[TBL] [Abstract][Full Text] [Related]
5. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
[TBL] [Abstract][Full Text] [Related]
6. γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
Hedskog L; Petersen CA; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
J Cell Mol Med; 2011 Oct; 15(10):2150-63. PubMed ID: 21054783
[TBL] [Abstract][Full Text] [Related]
7. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
Pintchovski SA; Schenk DB; Basi GS
Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
[TBL] [Abstract][Full Text] [Related]
8. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
9. Insulin-Like Growth Factor-1 Alleviates Expression of Aβ
Song F; Liu T; Meng S; Li F; Zhang Y; Jiang L
J Mol Neurosci; 2018 Dec; 66(4):595-603. PubMed ID: 30414017
[TBL] [Abstract][Full Text] [Related]
10. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
Ma L; Ohyagi Y; Miyoshi K; Sakae N; Motomura K; Taniwaki T; Furuya H; Takeda K; Tabira T; Kira J
J Alzheimers Dis; 2009; 16(3):565-75. PubMed ID: 19276551
[TBL] [Abstract][Full Text] [Related]
11. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
Wang J; Lu R; Yang J; Li H; He Z; Jing N; Wang X; Wang Y
Nat Commun; 2015 Nov; 6():8876. PubMed ID: 26581893
[TBL] [Abstract][Full Text] [Related]
12. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
Octave JN; Essalmani R; Tasiaux B; Menager J; Czech C; Mercken L
J Biol Chem; 2000 Jan; 275(3):1525-8. PubMed ID: 10636839
[TBL] [Abstract][Full Text] [Related]
13. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
14. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
Pitsi D; Kienlen-Campard P; Octave JN
J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
[TBL] [Abstract][Full Text] [Related]
15. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
16. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
Kim M; Bezprozvanny I
Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
[TBL] [Abstract][Full Text] [Related]
17. An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity.
Lu J; Cui J; Li X; Wang X; Zhou Y; Yang W; Chen M; Zhao J; Pei G
PLoS One; 2016; 11(11):e0166415. PubMed ID: 27835671
[TBL] [Abstract][Full Text] [Related]
18. Selenium and Zinc against Aβ
Li GZ; Liu F; Xu C; Li JY; Xu YJ
Biol Trace Elem Res; 2018 Aug; 184(2):442-449. PubMed ID: 29081063
[TBL] [Abstract][Full Text] [Related]
19. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
20. Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.
Zoltowska KM; Berezovska O
Mol Neurobiol; 2018 Mar; 55(3):2275-2284. PubMed ID: 28332150
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
