BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 16188951)

  • 1. Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
    Nelson CP; Nahorski SR; Challiss RA
    J Pharmacol Exp Ther; 2006 Jan; 316(1):279-88. PubMed ID: 16188951
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins.
    Mistry R; Dowling MR; Challiss RA
    Br J Pharmacol; 2005 Feb; 144(4):566-75. PubMed ID: 15655507
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.
    Dowling MR; Willets JM; Budd DC; Charlton SJ; Nahorski SR; Challiss RA
    J Pharmacol Exp Ther; 2006 Jun; 317(3):1134-42. PubMed ID: 16489127
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland.
    Nelson CP; Gupta P; Napier CM; Nahorski SR; Challiss RA
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1255-65. PubMed ID: 15140916
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The constitutive activity of the human muscarinic M3 receptor unmasks differences in the pharmacology of anticholinergics.
    Casarosa P; Kiechle T; Sieger P; Pieper M; Gantner F
    J Pharmacol Exp Ther; 2010 Apr; 333(1):201-9. PubMed ID: 20035022
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible noncompetitive antagonism at G protein-coupled receptors.
    Bodenstein J; Venter DP; Brink CB
    J Pharmacol Exp Ther; 2005 Aug; 314(2):891-905. PubMed ID: 15857948
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells.
    Hornigold DC; Mistry R; Raymond PD; Blank JL; Challiss RA
    Br J Pharmacol; 2003 Apr; 138(7):1340-50. PubMed ID: 12711635
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.
    May LT; Avlani VA; Langmead CJ; Herdon HJ; Wood MD; Sexton PM; Christopoulos A
    Mol Pharmacol; 2007 Aug; 72(2):463-76. PubMed ID: 17525129
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
    Olianas MC; Maullu C; Adem A; Mulugeta E; Karlsson E; Onali P
    Br J Pharmacol; 2000 Oct; 131(3):447-52. PubMed ID: 11015294
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo.
    Schrage R; Holze J; Klöckner J; Balkow A; Klause AS; Schmitz AL; De Amici M; Kostenis E; Tränkle C; Holzgrabe U; Mohr K
    Biochem Pharmacol; 2014 Aug; 90(3):307-19. PubMed ID: 24863257
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
    De Lorme KC; Grant MK; Noetzel MJ; Polson SB; El-Fakahany EE
    J Pharmacol Exp Ther; 2007 Dec; 323(3):868-76. PubMed ID: 17855477
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand specific up-regulation of a Renilla reniformis luciferase-tagged, structurally unstable muscarinic M3 chimeric G protein-coupled receptor.
    Zeng FY; McLean AJ; Milligan G; Lerner M; Chalmers DT; Behan DP
    Mol Pharmacol; 2003 Dec; 64(6):1474-84. PubMed ID: 14645678
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential modulation of agonist potency and receptor coupling by mutations of Ser388Tyr and Thr389Pro at the junction of transmembrane domain VI and the third extracellular loop of human M(1) muscarinic acetylcholine receptors.
    Huang XP; Williams FE; Peseckis SM; Messer WS
    Mol Pharmacol; 1999 Oct; 56(4):775-83. PubMed ID: 10496961
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins.
    Michal P; El-Fakahany EE; Dolezal V
    J Pharmacol Exp Ther; 2007 Feb; 320(2):607-14. PubMed ID: 17065363
    [TBL] [Abstract][Full Text] [Related]  

  • 15. G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists.
    Thomas RL; Mistry R; Langmead CJ; Wood MD; Challiss RA
    J Pharmacol Exp Ther; 2008 Nov; 327(2):365-74. PubMed ID: 18664591
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization.
    Sawyer GW; Ehlert FJ; Shults CA
    J Pharmacol Exp Ther; 2008 Jan; 324(1):196-205. PubMed ID: 17540859
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators.
    May LT; Lin Y; Sexton PM; Christopoulos A
    J Pharmacol Exp Ther; 2005 Jan; 312(1):382-90. PubMed ID: 15333678
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
    Jakubík J; El-Fakahany EE; Dolezal V
    Mol Pharmacol; 2006 Aug; 70(2):656-66. PubMed ID: 16675658
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6.
    Spalding TA; Burstein ES; Wells JW; Brann MR
    Biochemistry; 1997 Aug; 36(33):10109-16. PubMed ID: 9254607
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.
    Olianas MC; Adem A; Karlsson E; Onali P
    Eur J Pharmacol; 2004 Mar; 487(1-3):65-72. PubMed ID: 15033377
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.