BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 16195401)

  • 1. Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action.
    Allan GJ; Tonner E; Szymanowska M; Shand JH; Kelly SM; Phillips K; Clegg RA; Gow IF; Beattie J; Flint DJ
    Endocrinology; 2006 Jan; 147(1):338-49. PubMed ID: 16195401
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Substitution of specific amino acids in insulin-like growth factor (IGF) binding protein 5 alters heparin binding and its change in affinity for IGF-I response to heparin.
    Arai T; Clarke J; Parker A; Busby W; Nam T; Clemmons DR
    J Biol Chem; 1996 Mar; 271(11):6099-106. PubMed ID: 8626396
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.
    Fowlkes JL; Thrailkill KM; George-Nascimento C; Rosenberg CK; Serra DM
    Endocrinology; 1997 Jun; 138(6):2280-5. PubMed ID: 9165012
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I.
    Shand JH; Beattie J; Song H; Phillips K; Kelly SM; Flint DJ; Allan GJ
    J Biol Chem; 2003 May; 278(20):17859-66. PubMed ID: 12626499
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Amino acids within the extracellular matrix (ECM) binding region (201-218) of rat insulin-like growth factor binding protein (IGFBP)-5 are important determinants in binding IGF-I.
    Bramani S; Song H; Beattie J; Tonner E; Flint DJ; Allan GJ
    J Mol Endocrinol; 1999 Aug; 23(1):117-23. PubMed ID: 10425523
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
    Imai Y; Moralez A; Andag U; Clarke JB; Busby WH; Clemmons DR
    J Biol Chem; 2000 Jun; 275(24):18188-94. PubMed ID: 10766744
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.
    Bach LA; Hsieh S; Sakano K; Fujiwara H; Perdue JF; Rechler MM
    J Biol Chem; 1993 May; 268(13):9246-54. PubMed ID: 7683646
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth.
    Nam TJ; Busby WH; Rees C; Clemmons DR
    Endocrinology; 2000 Mar; 141(3):1100-6. PubMed ID: 10698186
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding.
    Firth SM; Clemmons DR; Baxter RC
    Endocrinology; 2001 May; 142(5):2147. PubMed ID: 11316783
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding.
    Headey SJ; Leeding KS; Norton RS; Bach LA
    J Mol Endocrinol; 2004 Oct; 33(2):377-86. PubMed ID: 15525596
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural changes in insulin-like growth factor (IGF) I mutant proteins affecting binding kinetic rates to IGF binding protein 1 and IGF-I receptor.
    Jansson M; Uhlen M; Nilsson B
    Biochemistry; 1997 Apr; 36(14):4108-17. PubMed ID: 9100004
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes.
    Sunic D; McNeil JD; Rayner TE; Andress DL; Belford DA
    Endocrinology; 1998 May; 139(5):2356-62. PubMed ID: 9564845
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions.
    Moralez AM; Maile LA; Clarke J; Busby WH; Clemmons DR
    J Cell Physiol; 2005 May; 203(2):328-34. PubMed ID: 15700281
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors.
    Reeve JG; Morgan J; Schwander J; Bleehen NM
    Cancer Res; 1993 Oct; 53(19):4680-5. PubMed ID: 7691401
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery and characterization of IGFBP-mediated endocytosis in the human retinal pigment epithelial cell line ARPE-19.
    Ainscough SL; Feigl B; Malda J; Harkin DG
    Exp Eye Res; 2009 Nov; 89(5):629-37. PubMed ID: 19540231
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.
    Kalus W; Zweckstetter M; Renner C; Sanchez Y; Georgescu J; Grol M; Demuth D; Schumacher R; Dony C; Lang K; Holak TA
    EMBO J; 1998 Nov; 17(22):6558-72. PubMed ID: 9822601
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-α activation in breast cancer cells in an IGF-independent manner.
    Hermani A; Shukla A; Medunjanin S; Werner H; Mayer D
    Cell Signal; 2013 Jun; 25(6):1395-402. PubMed ID: 23499909
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance.
    Dubaquié Y; Mortensen DL; Intintoli A; Hogue DA; Nakamura G; Rancatore P; Lester P; Sadick MD; Filvaroff E; Fielder PJ; Lowman HB
    Endocrinology; 2001 Jan; 142(1):165-73. PubMed ID: 11145579
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.
    Siwanowicz I; Popowicz GM; Wisniewska M; Huber R; Kuenkele KP; Lang K; Engh RA; Holak TA
    Structure; 2005 Jan; 13(1):155-67. PubMed ID: 15642270
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3.
    Dubaquié Y; Lowman HB
    Biochemistry; 1999 May; 38(20):6386-96. PubMed ID: 10350456
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.