These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 16199156)

  • 1. Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.
    Han S; Zhou V; Pan S; Liu Y; Hornsby M; McMullan D; Klock HE; Haugen J; Lesley SA; Gray N; Caldwell J; Gu XJ
    Bioorg Med Chem Lett; 2005 Dec; 15(24):5467-73. PubMed ID: 16199156
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
    Ohren JF; Chen H; Pavlovsky A; Whitehead C; Zhang E; Kuffa P; Yan C; McConnell P; Spessard C; Banotai C; Mueller WT; Delaney A; Omer C; Sebolt-Leopold J; Dudley DT; Leung IK; Flamme C; Warmus J; Kaufman M; Barrett S; Tecle H; Hasemann CA
    Nat Struct Mol Biol; 2004 Dec; 11(12):1192-7. PubMed ID: 15543157
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enzyme kinetics and binding studies on inhibitors of MEK protein kinase.
    VanScyoc WS; Holdgate GA; Sullivan JE; Ward WH
    Biochemistry; 2008 Apr; 47(17):5017-27. PubMed ID: 18393446
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor.
    Yeh TC; Marsh V; Bernat BA; Ballard J; Colwell H; Evans RJ; Parry J; Smith D; Brandhuber BJ; Gross S; Marlow A; Hurley B; Lyssikatos J; Lee PA; Winkler JD; Koch K; Wallace E
    Clin Cancer Res; 2007 Mar; 13(5):1576-83. PubMed ID: 17332304
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
    Fischmann TO; Smith CK; Mayhood TW; Myers JE; Reichert P; Mannarino A; Carr D; Zhu H; Wong J; Yang RS; Le HV; Madison VS
    Biochemistry; 2009 Mar; 48(12):2661-74. PubMed ID: 19161339
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.
    El Abdellaoui H; Varaprasad CV; Barawkar D; Chakravarty S; Maderna A; Tam R; Chen H; Allan M; Wu JZ; Appleby T; Yan S; Zhang W; Lang S; Yao N; Hamatake R; Hong Z
    Bioorg Med Chem Lett; 2006 Nov; 16(21):5561-6. PubMed ID: 16934458
    [TBL] [Abstract][Full Text] [Related]  

  • 7. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.
    Iverson C; Larson G; Lai C; Yeh LT; Dadson C; Weingarten P; Appleby T; Vo T; Maderna A; Vernier JM; Hamatake R; Miner JN; Quart B
    Cancer Res; 2009 Sep; 69(17):6839-47. PubMed ID: 19706763
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1.
    Kogut MH; Genovese KJ; He H
    Mol Immunol; 2007 Mar; 44(7):1729-36. PubMed ID: 17045653
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNFalpha in human epidermal keratinocytes (HaCaT).
    Onda K; Nagashima M; Kawakubo Y; Inoue S; Hirano T; Oka K
    Biochem Biophys Res Commun; 2006 Dec; 351(1):266-72. PubMed ID: 17054908
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.
    Yang R; Piperdi S; Gorlick R
    Clin Cancer Res; 2008 Oct; 14(20):6396-404. PubMed ID: 18927278
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.
    Marzec M; Kasprzycka M; Liu X; Raghunath PN; Wlodarski P; Wasik MA
    Oncogene; 2007 Feb; 26(6):813-21. PubMed ID: 16909118
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway.
    Zaheer RS; Koetzler R; Holden NS; Wiehler S; Proud D
    J Immunol; 2009 Apr; 182(8):4854-64. PubMed ID: 19342664
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.
    Piao C; Jin M; Kim HB; Lee SM; Amatya PN; Hyun JW; Chang IY; You HJ
    Oncogene; 2009 May; 28(21):2173-84. PubMed ID: 19398949
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
    Yip-Schneider MT; Klein PJ; Wentz SC; Zeni A; Menze A; Schmidt CM
    J Pharmacol Exp Ther; 2009 Jun; 329(3):1063-70. PubMed ID: 19258520
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.
    Hsu TS; Chen C; Lee PT; Chiu SJ; Liu HF; Tsai CC; Chao JI
    Cancer Chemother Pharmacol; 2008 Oct; 62(5):799-808. PubMed ID: 18193228
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
    Mallon R; Feldberg L; Kim S; Collins K; Wojciechowicz D; Kohler C; Kovacs D; Discafani C; Zhang N; Wu B; Floyd B; Powell D; Berger D
    Mol Cancer Ther; 2004 Jun; 3(6):755-62. PubMed ID: 15210862
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
    Matsuura I; Wang G; He D; Liu F
    Biochemistry; 2005 Sep; 44(37):12546-53. PubMed ID: 16156666
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
    Spicer JA; Rewcastle GW; Kaufman MD; Black SL; Plummer MS; Denny WA; Quin J; Shahripour AB; Barrett SD; Whitehead CE; Milbank JB; Ohren JF; Gowan RC; Omer C; Camp HS; Esmaeil N; Moore K; Sebolt-Leopold JS; Pryzbranowski S; Merriman RL; Ortwine DF; Warmus JS; Flamme CM; Pavlovsky AG; Tecle H
    J Med Chem; 2007 Oct; 50(21):5090-102. PubMed ID: 17880056
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.
    Schirmer A; Kennedy J; Murli S; Reid R; Santi DV
    Proc Natl Acad Sci U S A; 2006 Mar; 103(11):4234-9. PubMed ID: 16537514
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the ERK signaling pathway in cancer therapy.
    Kohno M; Pouyssegur J
    Ann Med; 2006; 38(3):200-11. PubMed ID: 16720434
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.