These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

94 related articles for article (PubMed ID: 16202589)

  • 1. Structure-based discovery of a new class of Hsp90 inhibitors.
    Barril X; Brough P; Drysdale M; Hubbard RE; Massey A; Surgenor A; Wright L
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5187-91. PubMed ID: 16202589
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel class of Hsp90 inhibitors isolated by structure-based virtual screening.
    Park H; Kim YJ; Hahn JS
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6345-9. PubMed ID: 17869098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors.
    Lauria A; Ippolito M; Almerico AM
    Comput Biol Chem; 2009 Oct; 33(5):386-90. PubMed ID: 19660987
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.
    Vallée F; Carrez C; Pilorge F; Dupuy A; Parent A; Bertin L; Thompson F; Ferrari P; Fassy F; Lamberton A; Thomas A; Arrebola R; Guerif S; Rohaut A; Certal V; Ruxer JM; Gouyon T; Delorme C; Jouanen A; Dumas J; Grépin C; Combeau C; Goulaouic H; Dereu N; Mikol V; Mailliet P; Minoux H
    J Med Chem; 2011 Oct; 54(20):7206-19. PubMed ID: 21972823
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
    He H; Zatorska D; Kim J; Aguirre J; Llauger L; She Y; Wu N; Immormino RM; Gewirth DT; Chiosis G
    J Med Chem; 2006 Jan; 49(1):381-90. PubMed ID: 16392823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
    Kung PP; Funk L; Meng J; Collins M; Zhou JZ; Johnson MC; Ekker A; Wang J; Mehta P; Yin MJ; Rodgers C; Davies JF; Bayman E; Smeal T; Maegley KA; Gehring MR
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6273-8. PubMed ID: 18929486
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inside the Hsp90 inhibitors binding mode through induced fit docking.
    Lauria A; Ippolito M; Almerico AM
    J Mol Graph Model; 2009 Feb; 27(6):712-22. PubMed ID: 19084447
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.
    Li X; Shocron E; Song A; Patel N; Sun CL
    Bioorg Med Chem Lett; 2009 May; 19(10):2860-4. PubMed ID: 19395259
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
    Dymock BW; Barril X; Brough PA; Cansfield JE; Massey A; McDonald E; Hubbard RE; Surgenor A; Roughley SD; Webb P; Workman P; Wright L; Drysdale MJ
    J Med Chem; 2005 Jun; 48(13):4212-5. PubMed ID: 15974572
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
    Barta TE; Veal JM; Rice JW; Partridge JM; Fadden RP; Ma W; Jenks M; Geng L; Hanson GJ; Huang KH; Barabasz AF; Foley BE; Otto J; Hall SE
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3517-21. PubMed ID: 18511277
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
    Huth JR; Park C; Petros AM; Kunzer AR; Wendt MD; Wang X; Lynch CL; Mack JC; Swift KM; Judge RA; Chen J; Richardson PL; Jin S; Tahir SK; Matayoshi ED; Dorwin SA; Ladror US; Severin JM; Walter KA; Bartley DM; Fesik SW; Elmore SW; Hajduk PJ
    Chem Biol Drug Des; 2007 Jul; 70(1):1-12. PubMed ID: 17630989
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of new Hsp90 inhibitors by structure-based virtual screening.
    Hong TJ; Park H; Kim YJ; Jeong JH; Hahn JS
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4839-42. PubMed ID: 19560353
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Derrubone, an inhibitor of the Hsp90 protein folding machinery.
    Hadden MK; Galam L; Gestwicki JE; Matts RL; Blagg BS
    J Nat Prod; 2007 Dec; 70(12):2014-8. PubMed ID: 18020309
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.
    Kung PP; Huang B; Zhang G; Zhou JZ; Wang J; Digits JA; Skaptason J; Yamazaki S; Neul D; Zientek M; Elleraas J; Mehta P; Yin MJ; Hickey MJ; Gajiwala KS; Rodgers C; Davies JF; Gehring MR
    J Med Chem; 2010 Jan; 53(1):499-503. PubMed ID: 19908836
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
    Kasibhatla SR; Hong K; Biamonte MA; Busch DJ; Karjian PL; Sensintaffar JL; Kamal A; Lough RE; Brekken J; Lundgren K; Grecko R; Timony GA; Ran Y; Mansfield R; Fritz LC; Ulm E; Burrows FJ; Boehm MF
    J Med Chem; 2007 Jun; 50(12):2767-78. PubMed ID: 17488003
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hsp90 inhibitors and drugs from fragment and virtual screening.
    Roughley S; Wright L; Brough P; Massey A; Hubbard RE
    Top Curr Chem; 2012; 317():61-82. PubMed ID: 21647838
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
    Cheung KM; Matthews TP; James K; Rowlands MG; Boxall KJ; Sharp SY; Maloney A; Roe SM; Prodromou C; Pearl LH; Aherne GW; McDonald E; Workman P
    Bioorg Med Chem Lett; 2005 Jul; 15(14):3338-43. PubMed ID: 15955698
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
    Murray CW; Carr MG; Callaghan O; Chessari G; Congreve M; Cowan S; Coyle JE; Downham R; Figueroa E; Frederickson M; Graham B; McMenamin R; O'Brien MA; Patel S; Phillips TR; Williams G; Woodhead AJ; Woolford AJ
    J Med Chem; 2010 Aug; 53(16):5942-55. PubMed ID: 20718493
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
    Gopalsamy A; Shi M; Golas J; Vogan E; Jacob J; Johnson M; Lee F; Nilakantan R; Petersen R; Svenson K; Chopra R; Tam MS; Wen Y; Ellingboe J; Arndt K; Boschelli F
    J Med Chem; 2008 Feb; 51(3):373-5. PubMed ID: 18197612
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery.
    Burlison JA; Blagg BS
    Org Lett; 2006 Oct; 8(21):4855-8. PubMed ID: 17020320
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.