These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

111 related articles for article (PubMed ID: 16204896)

  • 1. Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.
    Jin L; Pandey P; Babine RE; Weaver DT; Abdel-Meguid SS; Strickler JE
    Acta Crystallogr D Biol Crystallogr; 2005 Oct; 61(Pt 10):1418-25. PubMed ID: 16204896
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions.
    Jin L; Pandey P; Babine RE; Gorga JC; Seidl KJ; Gelfand E; Weaver DT; Abdel-Meguid SS; Strickler JE
    J Biol Chem; 2005 Feb; 280(6):4704-12. PubMed ID: 15545266
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
    Navaneetham D; Jin L; Pandey P; Strickler JE; Babine RE; Abdel-Meguid SS; Walsh PN
    J Biol Chem; 2005 Oct; 280(43):36165-75. PubMed ID: 16085935
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.
    Schmidt AE; Sun MF; Ogawa T; Bajaj SP; Gailani D
    Biochemistry; 2008 Feb; 47(5):1326-35. PubMed ID: 18186617
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical Footprinting Reveals Conformational Changes Following Activation of Factor XI.
    Stroo I; Marquart JA; Bakhtiari K; Plug T; Meijer AB; Meijers JCM
    Thromb Haemost; 2018 Feb; 118(2):340-350. PubMed ID: 29378358
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI.
    Schmidt AE; Ogawa T; Gailani D; Bajaj SP
    J Biol Chem; 2004 Jul; 279(28):29485-92. PubMed ID: 15090552
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.
    Fjellström O; Akkaya S; Beisel HG; Eriksson PO; Erixon K; Gustafsson D; Jurva U; Kang D; Karis D; Knecht W; Nerme V; Nilsson I; Olsson T; Redzic A; Roth R; Sandmark J; Tigerström A; Öster L
    PLoS One; 2015; 10(1):e0113705. PubMed ID: 25629509
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.
    Geng Y; Verhamme IM; Sun MF; Bajaj SP; Emsley J; Gailani D
    J Thromb Haemost; 2013 Jul; 11(7):1374-84. PubMed ID: 23617568
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.
    Miller TN; Sinha D; Baird TR; Walsh PN
    Biochemistry; 2007 Dec; 46(50):14450-60. PubMed ID: 18020374
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
    Lin J; Deng H; Jin L; Pandey P; Quinn J; Cantin S; Rynkiewicz MJ; Gorga JC; Bibbins F; Celatka CA; Nagafuji P; Bannister TD; Meyers HV; Babine RE; Hayward NJ; Weaver D; Benjamin H; Stassen F; Abdel-Meguid SS; Strickler JE
    J Med Chem; 2006 Dec; 49(26):7781-91. PubMed ID: 17181160
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
    Fradera X; Kazemier B; Carswell E; Cooke A; Oubrie A; Hamilton W; Dempster M; Krapp S; Nagel S; Jestel A
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2012 Apr; 68(Pt 4):404-8. PubMed ID: 22505407
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa.
    Wu W; Sinha D; Shikov S; Yip CK; Walz T; Billings PC; Lear JD; Walsh PN
    J Biol Chem; 2008 Jul; 283(27):18655-64. PubMed ID: 18441012
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hydrogen-deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa.
    Bar Barroeta A; van Galen J; Stroo I; Marquart JA; Meijer AB; Meijers JCM
    J Thromb Haemost; 2019 Dec; 17(12):2047-2055. PubMed ID: 31519061
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Productive recognition of factor IX by factor XIa exosites requires disulfide linkage between heavy and light chains of factor XIa.
    Marcinkiewicz MM; Sinha D; Walsh PN
    J Biol Chem; 2012 Feb; 287(9):6187-95. PubMed ID: 22207756
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation.
    Smith SB; Verhamme IM; Sun MF; Bock PE; Gailani D
    J Biol Chem; 2008 Mar; 283(11):6696-705. PubMed ID: 18192270
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity.
    Ramesh K; Lama D; Tan KW; Nguyen VS; Chew FT; Verma CS; Mok YK
    Structure; 2018 Sep; 26(9):1178-1186.e3. PubMed ID: 30017565
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity.
    Rezaie AR; Sun MF; Gailani D
    Biochemistry; 2006 Aug; 45(31):9427-33. PubMed ID: 16878977
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.
    Schaefer M; Buchmueller A; Dittmer F; Straßburger J; Wilmen A
    J Mol Biol; 2019 Dec; 431(24):4817-4833. PubMed ID: 31655039
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structures of human factor Xa complexed with potent inhibitors.
    Maignan S; Guilloteau JP; Pouzieux S; Choi-Sledeski YM; Becker MR; Klein SI; Ewing WR; Pauls HW; Spada AP; Mikol V
    J Med Chem; 2000 Aug; 43(17):3226-32. PubMed ID: 10966741
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation.
    Sinha D; Marcinkiewicz M; Navaneetham D; Walsh PN
    Biochemistry; 2007 Aug; 46(34):9830-9. PubMed ID: 17676929
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.