BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 16219465)

  • 1. Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.
    Kling A; Lange UE; Mack H; Bakker MH; Drescher KU; Hornberger W; Hutchins CW; Möller A; Müller R; Schmidt M; Unger L; Wicke K; Schellhaas K; Steiner G
    Bioorg Med Chem Lett; 2005 Dec; 15(24):5567-73. PubMed ID: 16219465
    [TBL] [Abstract][Full Text] [Related]  

  • 2. QSAR study on dual 5-HT1A and 5-HT1B antagonists: an insight into the structural requirement for antidepressant activity.
    Dessalew N
    Arch Pharm (Weinheim); 2008 May; 341(5):314-22. PubMed ID: 18389517
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
    Mewshaw RE; Zhou D; Zhou P; Shi X; Hornby G; Spangler T; Scerni R; Smith D; Schechter LE; Andree TH
    J Med Chem; 2004 Jul; 47(15):3823-42. PubMed ID: 15239661
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S; Kołaczkowski M; Maryniak E; Zajdel P; Pawłowski M; Tatarczyńska E; Kłodzińska A; Chojnacka-Wójcik E; Bojarski AJ; Charakchieva-Minol S; Duszyńska B; Nowak G; Maciag D
    J Med Chem; 2004 May; 47(10):2659-66. PubMed ID: 15115407
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.
    de Boer SF; Koolhaas JM
    Eur J Pharmacol; 2005 Dec; 526(1-3):125-39. PubMed ID: 16310183
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.
    Childers WE; Havran LM; Asselin M; Bicksler JJ; Chong DC; Grosu GT; Shen Z; Abou-Gharbia MA; Bach AC; Harrison BL; Kagan N; Kleintop T; Magolda R; Marathias V; Robichaud AJ; Sabb AL; Zhang MY; Andree TH; Aschmies SH; Beyer C; Comery TA; Day M; Grauer SM; Hughes ZA; Rosenzweig-Lipson S; Platt B; Pulicicchio C; Smith DE; Sukoff-Rizzo SJ; Sullivan KM; Adedoyin A; Huselton C; Hirst WD
    J Med Chem; 2010 May; 53(10):4066-84. PubMed ID: 20443629
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
    Zhou D; Zhou P; Evrard DA; Meagher K; Webb M; Harrison BL; Huryn DM; Golembieski J; Hornby GA; Schechter LE; Smith DL; Andree TH; Mewshaw RE
    Bioorg Med Chem; 2008 Jul; 16(14):6707-23. PubMed ID: 18571421
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.
    Ward SE; Eddershaw PJ; Scott CM; Gordon LJ; Lovell PJ; Moore SH; Smith PW; Starr KR; Thewlis KM; Watson JM
    J Med Chem; 2008 May; 51(10):2887-90. PubMed ID: 18433113
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor.
    Moloney GP; Martin GR; Mathews N; Milne A; Hobbs H; Dodsworth S; Sang PY; Knight C; Williams M; Maxwell M; Glen RC
    J Med Chem; 1999 Jul; 42(14):2504-26. PubMed ID: 10411472
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ; Paluchowska MH; Duszyńska B; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
    Bioorg Med Chem; 2005 Mar; 13(6):2293-303. PubMed ID: 15727878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
    Siracusa MA; Salerno L; Modica MN; Pittalà V; Romeo G; Amato ME; Nowak M; Bojarski AJ; Mereghetti I; Cagnotto A; Mennini T
    J Med Chem; 2008 Aug; 51(15):4529-38. PubMed ID: 18598015
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.
    Volk B; Gacsályi I; Pallagi K; Poszávácz L; Gyönös I; Szabó E; Bakó T; Spedding M; Simig G; Szénási G
    J Med Chem; 2011 Oct; 54(19):6657-69. PubMed ID: 21859099
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA; Sallander J; Benhamú B; Porras E; Campillo M; Pardo L; López-Rodríguez ML
    J Med Chem; 2009 Apr; 52(8):2384-92. PubMed ID: 19326916
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats.
    Liu FY; Xing GG; Qu XX; Xu IS; Han JS; Wan Y
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1046-53. PubMed ID: 17329553
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
    Sorbi C; Franchini S; Tait A; Prandi A; Gallesi R; Angeli P; Marucci G; Pirona L; Poggesi E; Brasili L
    ChemMedChem; 2009 Mar; 4(3):393-9. PubMed ID: 19152363
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
    Zajdel P; Subra G; Bojarski AJ; Duszyńska B; Tatarczyńska E; Nikiforuk A; Chojnacka-Wójcik E; Pawłowski M; Martinez J
    Bioorg Med Chem; 2007 Apr; 15(8):2907-19. PubMed ID: 17321139
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.
    Leopoldo M; Lacivita E; Colabufo NA; Niso M; Berardi F; Perrone R
    Bioorg Med Chem; 2007 Aug; 15(15):5316-21. PubMed ID: 17517509
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
    Fiorino F; Perissutti E; Severino B; Santagada V; Cirillo D; Terracciano S; Massarelli P; Bruni G; Collavoli E; Renner C; Caliendo G
    J Med Chem; 2005 Aug; 48(17):5495-503. PubMed ID: 16107148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [N-methyl-3H3]AZ10419369 binding to the 5-HT1B receptor: in vitro characterization and in vivo receptor occupancy.
    Maier DL; Sobotka-Briner C; Ding M; Powell ME; Jiang Q; Hill G; Heys JR; Elmore CS; Pierson ME; Mrzljak L
    J Pharmacol Exp Ther; 2009 Jul; 330(1):342-51. PubMed ID: 19401496
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and 5-HT(1A), 5-HT(2A) receptor activity of new beta-tetralonohydantoins.
    Byrtus H; Pawłowski M; Czopek A; Bojarski AJ; Duszyńska B; Nowak G; Kłodzińska A; Tatarczyńska E; Wesołowska A; Chojnacka-Wójcik E
    Eur J Med Chem; 2005 Aug; 40(8):820-9. PubMed ID: 16122584
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.