BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

91 related articles for article (PubMed ID: 16229470)

  • 1. Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides.
    Esh C; Patton L; Kalback W; Kokjohn TA; Lopez J; Brune D; Newell AJ; Beach T; Schenk D; Games D; Paul S; Bales K; Ghetti B; Castaño EM; Roher AE
    Biochemistry; 2005 Oct; 44(42):13807-19. PubMed ID: 16229470
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
    Van Vickle GD; Esh CL; Kalback WM; Patton RL; Luehrs DC; Kokjohn TA; Fifield FG; Fraser PE; Westaway D; McLaurin J; Lopez J; Brune D; Newel AJ; Poston M; Beach TG; Roher AE
    Biochemistry; 2007 Sep; 46(36):10317-27. PubMed ID: 17705508
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J; Williamson NA; Hill AF; Sernee MF; Masters CL; Small DH
    J Neurosci Res; 2003 Nov; 74(3):378-85. PubMed ID: 14598314
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alzheimer's disease.
    De-Paula VJ; Radanovic M; Diniz BS; Forlenza OV
    Subcell Biochem; 2012; 65():329-52. PubMed ID: 23225010
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 6. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
    Kalback W; Watson MD; Kokjohn TA; Kuo YM; Weiss N; Luehrs DC; Lopez J; Brune D; Sisodia SS; Staufenbiel M; Emmerling M; Roher AE
    Biochemistry; 2002 Jan; 41(3):922-8. PubMed ID: 11790115
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
    Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
    Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease.
    Green PS; Bales K; Paul S; Bu G
    Endocrinology; 2005 Jun; 146(6):2774-81. PubMed ID: 15731362
    [TBL] [Abstract][Full Text] [Related]  

  • 10. beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology.
    Vehmas AK; Borchelt DR; Price DL; McCarthy D; Wills-Karp M; Peper MJ; Rudow G; Luyinbazi J; Siew LT; Troncoso JC
    DNA Cell Biol; 2001 Nov; 20(11):713-21. PubMed ID: 11788049
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.
    Tian X; Cecal R; McLaurin J; Manea M; Stefanescu R; Grau S; Harnasch M; Amir S; Ehrmann M; St George-Hyslop P; Kohlmann M; Przybylski M
    Eur J Mass Spectrom (Chichester); 2005; 11(5):547-56. PubMed ID: 16322661
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.
    Cantone JL; Xu-Lin A; Toyn JH; Drexler DM
    J Neurosci Methods; 2009 Jun; 180(2):255-60. PubMed ID: 19464516
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.
    Maia LF; Kaeser SA; Reichwald J; Hruscha M; Martus P; Staufenbiel M; Jucker M
    Sci Transl Med; 2013 Jul; 5(194):194re2. PubMed ID: 23863834
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
    Neumann U; Rueeger H; Machauer R; Veenstra SJ; Lueoend RM; Tintelnot-Blomley M; Laue G; Beltz K; Vogg B; Schmid P; Frieauff W; Shimshek DR; Staufenbiel M; Jacobson LH
    Mol Neurodegener; 2015 Sep; 10():44. PubMed ID: 26336937
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice.
    Chiocco MJ; Lamb BT
    Neurobiol Aging; 2007 Jan; 28(1):75-84. PubMed ID: 16387391
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.
    Galvan V; Zhang J; Gorostiza OF; Banwait S; Huang W; Ataie M; Tang H; Bredesen DE
    Behav Brain Res; 2008 Aug; 191(2):246-55. PubMed ID: 18485495
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.
    Watson DJ; Selkoe DJ; Teplow DB
    Biochem J; 1999 Jun; 340 ( Pt 3)(Pt 3):703-9. PubMed ID: 10359654
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dominance of amyloid precursor protein sequence over host cell secretases in determining beta-amyloid profiles studies of interspecies variation and drug action by internally standardized immunoprecipitation/mass spectrometry.
    Du P; Wood KM; Rosner MH; Cunningham D; Tate B; Geoghegan KF
    J Pharmacol Exp Ther; 2007 Mar; 320(3):1144-52. PubMed ID: 17202404
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.