BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 16243824)

  • 1. Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts.
    Seo Y; Yan T; Schupp JE; Radivoyevitch T; Kinsella TJ
    Clin Cancer Res; 2005 Oct; 11(20):7499-507. PubMed ID: 16243824
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preclinical toxicity and efficacy study of a 14-day schedule of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine radiosensitization in U251 human glioblastoma xenografts.
    Kinsella TJ; Vielhuber KA; Kunugi KA; Schupp J; Davis TW; Sands H
    Clin Cancer Res; 2000 Apr; 6(4):1468-75. PubMed ID: 10778979
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues.
    Kinsella TJ; Kunugi KA; Vielhuber KA; Potter DM; Fitzsimmons ME; Collins JM
    Clin Cancer Res; 1998 Jan; 4(1):99-109. PubMed ID: 9516958
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An in vivo comparison of oral 5-iodo-2'-deoxyuridine and 5-iodo-2-pyrimidinone-2'-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116.
    Kinsella TJ; Kunugi KA; Vielhuber KA; McCulloch W; Liu SH; Cheng YC
    Cancer Res; 1994 May; 54(10):2695-700. PubMed ID: 8168099
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-iodo-2-pyrimidinone-2'-deoxyribose-mediated cytotoxicity and radiosensitization in U87 human glioblastoma xenografts.
    Kinsella TJ; Kinsella MT; Seo Y; Berk G
    Int J Radiat Oncol Biol Phys; 2007 Nov; 69(4):1254-61. PubMed ID: 17967315
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design.
    Kinsella TJ; Schupp JE; Davis TW; Berry SE; Hwang HS; Warren K; Balis F; Barnett J; Sands H
    Clin Cancer Res; 2000 Sep; 6(9):3670-9. PubMed ID: 10999760
    [TBL] [Abstract][Full Text] [Related]  

  • 7. IPdR: a novel oral radiosensitizer.
    Saif MW; Berk G; Cheng YC; Kinsella TJ
    Expert Opin Investig Drugs; 2007 Sep; 16(9):1415-24. PubMed ID: 17714027
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2'-deoxyribose.
    Seo Y; Yan T; Schupp JE; Colussi V; Taylor KL; Kinsella TJ
    Clin Cancer Res; 2004 Nov; 10(22):7520-8. PubMed ID: 15569982
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phase I and Pharmacology Study of Ropidoxuridine (IPdR) as Prodrug for Iododeoxyuridine-Mediated Tumor Radiosensitization in Advanced GI Cancer Undergoing Radiation.
    Kinsella T; Safran H; Wiersma S; DiPetrillo T; Schumacher A; Rosati K; Vatkevich J; Anderson LW; Hill KD; Kunos C; Collins JM
    Clin Cancer Res; 2019 Oct; 25(20):6035-6043. PubMed ID: 31337643
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
    Kinsella TJ; Kinsella MT; Hong S; Johnson JP; Burback B; Tosca PJ
    Cancer Chemother Pharmacol; 2008 Feb; 61(2):323-34. PubMed ID: 17562042
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conversion of 5-iodo-2-pyrimidinone-2'-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design.
    Chang CN; Doong SL; Cheng YC
    Biochem Pharmacol; 1992 May; 43(10):2269-73. PubMed ID: 1599512
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthetic, implantable polymers for IUdR radiosensitization of experimental human malignant glioma.
    Yuan X; Dillehay LE; Williams JR; Williams JA
    Cancer Biother Radiopharm; 1999 Jun; 14(3):187-202. PubMed ID: 10850303
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Implantable biodegradable polymers for IUdR radiosensitization of experimental human malignant glioma.
    Williams JA; Dillehay LE; Tabassi K; Sipos E; Fahlman C; Brem H
    J Neurooncol; 1997 May; 32(3):181-92. PubMed ID: 9049879
    [TBL] [Abstract][Full Text] [Related]  

  • 14. First-in-human phase 0 trial of oral 5-iodo-2-pyrimidinone-2'-deoxyribose in patients with advanced malignancies.
    Kummar S; Anderson L; Hill K; Majerova E; Allen D; Horneffer Y; Ivy SP; Rubinstein L; Harris P; Doroshow JH; Collins JM
    Clin Cancer Res; 2013 Apr; 19(7):1852-7. PubMed ID: 23403637
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthetic, implantable polymers for local delivery of IUdR to experimental human malignant glioma.
    Williams JA; Yuan X; Dillehay LE; Shastri VR; Brem H; Williams JR
    Int J Radiat Oncol Biol Phys; 1998 Oct; 42(3):631-9. PubMed ID: 9806525
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Iododeoxyuridine (IUdR) combined with radiation in the treatment of malignant glioma: a comparison of short versus long intravenous dose schedules (RTOG 86-12).
    Urtasun RC; Cosmatos D; DelRowe J; Kinsella TJ; Lester S; Wasserman T; Fulton DS
    Int J Radiat Oncol Biol Phys; 1993 Sep; 27(2):207-14. PubMed ID: 8407393
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
    Vokes EE; Dolan ME; Krishnasamy S; Mick R; Ratain MJ; Berezin F; Brachman D; Whitman G; Schilsky RL; Charette J
    Ann Oncol; 1993 Aug; 4(7):591-5. PubMed ID: 8395874
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A phase I study of intravenous iododeoxyuridine as a clinical radiosensitizer.
    Kinsella TJ; Russo A; Mitchell JB; Collins JM; Rowland J; Wright D; Glatstein E
    Int J Radiat Oncol Biol Phys; 1985 Nov; 11(11):1941-6. PubMed ID: 2997090
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Unlabelled iododeoxyuridine increases the cytotoxicity and incorporation of [1251]-iododeoxyuridine in two human glioblastoma cell lines.
    Xiao WH; Dupertuis YM; Mermillod B; Sun LQ; de Tribolet N; Buchegger F
    Nucl Med Commun; 2000 Oct; 21(10):947-53. PubMed ID: 11130336
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
    Cao S; McGuire JJ; Rustum YM
    Clin Cancer Res; 1999 Jul; 5(7):1925-34. PubMed ID: 10430100
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.