182 related articles for article (PubMed ID: 16246548)
1. Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I).
Zheng J; Wen R; Luo X; Lin G; Zhang J; Xu L; Guo L; Jiang H
Bioorg Med Chem Lett; 2006 Jan; 16(1):225-7. PubMed ID: 16246548
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.
Zhang J; Zhang P; Liu X; Fang K; Lin G
Bioorg Med Chem Lett; 2007 Jul; 17(13):3769-73. PubMed ID: 17517506
[TBL] [Abstract][Full Text] [Related]
3. GABA transporters as drug targets for modulation of GABAergic activity.
Schousboe A; Sarup A; Larsson OM; White HS
Biochem Pharmacol; 2004 Oct; 68(8):1557-63. PubMed ID: 15451399
[TBL] [Abstract][Full Text] [Related]
4. Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.
White HS; Sarup A; Bolvig T; Kristensen AS; Petersen G; Nelson N; Pickering DS; Larsson OM; Frølund B; Krogsgaard-Larsen P; Schousboe A
J Pharmacol Exp Ther; 2002 Aug; 302(2):636-44. PubMed ID: 12130726
[TBL] [Abstract][Full Text] [Related]
5. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Andersen KE; Braestrup C; Grønwald FC; Jørgensen AS; Nielsen EB; Sonnewald U; Sørensen PO; Suzdak PD; Knutsen LJ
J Med Chem; 1993 Jun; 36(12):1716-25. PubMed ID: 8510100
[TBL] [Abstract][Full Text] [Related]
6. Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
Faust MR; Höfner G; Pabel J; Wanner KT
Eur J Med Chem; 2010 Jun; 45(6):2453-66. PubMed ID: 20219271
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Andersen KE; Lau J; Lundt BF; Petersen H; Huusfeldt PO; Suzdak PD; Swedberg MD
Bioorg Med Chem; 2001 Nov; 9(11):2773-85. PubMed ID: 11597457
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.
Quandt G; Höfner G; Wanner KT
Bioorg Med Chem; 2013 Jun; 21(11):3363-78. PubMed ID: 23598250
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors.
Kulig K; Więckowski K; Więckowska A; Gajda J; Pochwat B; Höfner GC; Wanner KT; Malawska B
Eur J Med Chem; 2011 Jan; 46(1):183-90. PubMed ID: 21111516
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Knutsen LJ; Andersen KE; Lau J; Lundt BF; Henry RF; Morton HE; Naerum L; Petersen H; Stephensen H; Suzdak PD; Swedberg MD; Thomsen C; Sørensen PO
J Med Chem; 1999 Sep; 42(18):3447-62. PubMed ID: 10479278
[TBL] [Abstract][Full Text] [Related]
11. Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.
Worm K; Zhou QJ; Stabley GJ; DeHaven RN; Dolle RE
Bioorg Med Chem Lett; 2007 Jul; 17(13):3652-6. PubMed ID: 17507224
[TBL] [Abstract][Full Text] [Related]
12. GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Falch E; Krogsgaard-Larsen P
Drug Des Deliv; 1989 May; 4(3):205-15. PubMed ID: 2535204
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.
Clausen RP; Madsen K; Larsson OM; Frølund B; Krogsgaard-Larsen P; Schousboe A
Adv Pharmacol; 2006; 54():265-84. PubMed ID: 17175818
[No Abstract] [Full Text] [Related]
14. Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.
N'Goka V; Bissantz C; Bisel P; Stenbøl TB; Krogsgaard-Larsen P; Schlewer G
Eur J Med Chem; 2004 Jul; 39(7):633-8. PubMed ID: 15236844
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors.
Zhuang W; Zhao X; Zhao G; Guo L; Lian Y; Zhou J; Fang D
Bioorg Med Chem; 2009 Sep; 17(18):6540-6. PubMed ID: 19703775
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Andersen KE; Sørensen JL; Huusfeldt PO; Knutsen LJ; Lau J; Lundt BF; Petersen H; Suzdak PD; Swedberg MD
J Med Chem; 1999 Oct; 42(21):4281-91. PubMed ID: 10543872
[TBL] [Abstract][Full Text] [Related]
17. Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.
Pizzi DA; Leslie CP; Di Fabio R; Seri C; Bernasconi G; Squaglia M; Carnevale G; Falchi A; Greco E; Mangiarini L; Negri M
Bioorg Med Chem Lett; 2011 Jan; 21(1):602-5. PubMed ID: 21134748
[TBL] [Abstract][Full Text] [Related]
18. N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors.
Barf T; Lehmann F; Hammer K; Haile S; Axen E; Medina C; Uppenberg J; Svensson S; Rondahl L; Lundbäck T
Bioorg Med Chem Lett; 2009 Mar; 19(6):1745-8. PubMed ID: 19217286
[TBL] [Abstract][Full Text] [Related]
19. In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
Li J; Bronk BS; Dirlam JP; Blize AE; Bertinato P; Jaynes BH; Hickman A; Miskell C; Pillai UA; Tibbitts JS; Haven ML; Kolosko NL; Barry CJ; Manion TB
Bioorg Med Chem Lett; 2007 Apr; 17(7):1996-9. PubMed ID: 17276061
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.
Lakshminarayana N; Rajendra Prasad Y; Gharat L; Thomas A; Ravikumar P; Narayanan S; Srinivasan CV; Gopalan B
Eur J Med Chem; 2009 Aug; 44(8):3147-57. PubMed ID: 19349096
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
