BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 16246548)

  • 21. Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors.
    Nagata T; Nagamochi M; Kobayashi S; Komoriya S; Yoshino T; Kanno H
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4587-92. PubMed ID: 18675545
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
    Ye XY; Li YX; Farrelly D; Flynn N; Gu L; Locke KT; Lippy J; O'Malley K; Twamley C; Zhang L; Ryono DE; Zahler R; Hariharan N; Cheng PT
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3545-50. PubMed ID: 18511276
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.
    Tóth K; Höfner G; Wanner KT
    Bioorg Med Chem; 2018 Jul; 26(12):3668-3687. PubMed ID: 29886082
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids.
    N'goka V; Stenbøl TB; Krogsgaard-Larsen P; Schlewer G
    Eur J Med Chem; 2004 Oct; 39(10):889-95. PubMed ID: 15464623
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
    Andersen KE; Sørensen JL; Lau J; Lundt BF; Petersen H; Huusfeldt PO; Suzdak PD; Swedberg MD
    J Med Chem; 2001 Jun; 44(13):2152-63. PubMed ID: 11405652
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A convergent approach to (R)-Tiagabine by a regio- and stereocontrolled hydroiodination of alkynes.
    Bartoli G; Cipolletti R; Di Antonio G; Giovannini R; Lanari S; Marcolini M; Marcantoni E
    Org Biomol Chem; 2010 Aug; 8(15):3509-17. PubMed ID: 20532411
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.
    Zeng LF; Zhang HS; Wang YH; Sanchez T; Zheng YT; Neamati N; Long YQ
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4521-4. PubMed ID: 18662877
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors.
    Tóth K; Höfner G; Wanner KT
    Bioorg Med Chem; 2018 Dec; 26(22):5944-5961. PubMed ID: 30442505
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.
    Park CM; Kim SY; Park WK; Park NS; Seong CM
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3844-7. PubMed ID: 18602261
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).
    Jurik A; Zdrazil B; Holy M; Stockner T; Sitte HH; Ecker GF
    J Med Chem; 2015 Mar; 58(5):2149-58. PubMed ID: 25679268
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1.
    Xu Y; Cai Y; Gong N; Chen C; Wu Y; Zhang-Nunes S; Wang Z; Xu T; Fei J
    Biochem Biophys Res Commun; 2007 Sep; 361(2):499-504. PubMed ID: 17655829
    [TBL] [Abstract][Full Text] [Related]  

  • 32. The vinylfluoro group as an acetonyl cation equivalent: stereoselective synthesis of 6-substituted 4-hydroxy pipecolic acid derivatives.
    Purkayastha N; Shendage DM; Fröhlich R; Haufe G
    J Org Chem; 2010 Jan; 75(1):222-5. PubMed ID: 19968262
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
    Song DQ; Wang YM; Du NN; He WY; Chen KL; Wang GF; Yang P; Wu LZ; Zhang XB; Jiang JD
    Bioorg Med Chem Lett; 2009 Feb; 19(3):755-8. PubMed ID: 19111465
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis and evaluation of acylguanidine FXa inhibitors.
    O'Connor SP; Atwal K; Li C; Liu EC; Seiler SM; Shi M; Shi Y; Stein PD; Wang Y
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4696-9. PubMed ID: 18644722
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Medicinal chemistry of ρ GABAC receptors.
    Ng CK; Kim HL; Gavande N; Yamamoto I; Kumar RJ; Mewett KN; Johnston GA; Hanrahan JR; Chebib M
    Future Med Chem; 2011 Feb; 3(2):197-209. PubMed ID: 21428815
    [TBL] [Abstract][Full Text] [Related]  

  • 36. New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity.
    Yuan H; Silverman RB
    Bioorg Med Chem; 2006 Mar; 14(5):1331-8. PubMed ID: 16263300
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.
    Sato N; Jitsuoka M; Ishikawa S; Nagai K; Tsuge H; Ando M; Okamoto O; Iwaasa H; Gomori A; Ishihara A; Kanatani A; Fukami T
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1670-4. PubMed ID: 19233647
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4.
    Pabel J; Faust M; Prehn C; Wörlein B; Allmendinger L; Höfner G; Wanner KT
    ChemMedChem; 2012 Jul; 7(7):1245-55. PubMed ID: 22544452
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
    Moriarty KJ; Takahashi H; Pullen SS; Khine HH; Sallati RH; Raymond EL; Woska JR; Jeanfavre DD; Roth GP; Winters MP; Qiao L; Ryan D; DesJarlais R; Robinson D; Wilson M; Bobko M; Cook BN; Lo HY; Nemoto PA; Kashem MA; Wolak JP; White A; Magolda RL; Tomczuk B
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5545-9. PubMed ID: 18819799
    [TBL] [Abstract][Full Text] [Related]  

  • 40. High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study.
    Henjum S; Hassel B
    Neurochem Int; 2007 Jan; 50(2):365-70. PubMed ID: 17069932
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.