BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

338 related articles for article (PubMed ID: 16249345)

  • 1. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
    Conway JG; McDonald B; Parham J; Keith B; Rusnak DW; Shaw E; Jansen M; Lin P; Payne A; Crosby RM; Johnson JH; Frick L; Lin MH; Depee S; Tadepalli S; Votta B; James I; Fuller K; Chambers TJ; Kull FC; Chamberlain SD; Hutchins JT
    Proc Natl Acad Sci U S A; 2005 Nov; 102(44):16078-83. PubMed ID: 16249345
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats.
    Conway JG; Pink H; Bergquist ML; Han B; Depee S; Tadepalli S; Lin P; Crumrine RC; Binz J; Clark RL; Selph JL; Stimpson SA; Hutchins JT; Chamberlain SD; Brodie TA
    J Pharmacol Exp Ther; 2008 Jul; 326(1):41-50. PubMed ID: 18434589
    [TBL] [Abstract][Full Text] [Related]  

  • 3. c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.
    Paniagua RT; Chang A; Mariano MM; Stein EA; Wang Q; Lindstrom TM; Sharpe O; Roscow C; Ho PP; Lee DM; Robinson WH
    Arthritis Res Ther; 2010; 12(1):R32. PubMed ID: 20181277
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CSF-1R inhibition attenuates ischemia-induced renal injury and fibrosis by reducing Ly6C
    Deng X; Yang Q; Wang Y; Zhou C; Guo Y; Hu Z; Liao W; Xu G; Zeng R
    Int Immunopharmacol; 2020 Nov; 88():106854. PubMed ID: 32771945
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role for cFMS in maintaining alternative macrophage polarization in SIV infection: implications for HIV neuropathogenesis.
    Gerngross L; Lehmicke G; Belkadi A; Fischer T
    J Neuroinflammation; 2015 Mar; 12():58. PubMed ID: 25886134
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.
    Crespo O; Kang SC; Daneman R; Lindstrom TM; Ho PP; Sobel RA; Steinman L; Robinson WH
    J Clin Immunol; 2011 Dec; 31(6):1010-20. PubMed ID: 21847523
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.
    Neal ML; Fleming SM; Budge KM; Boyle AM; Kim C; Alam G; Beier EE; Wu LJ; Richardson JR
    FASEB J; 2020 Jan; 34(1):1679-1694. PubMed ID: 31914683
    [TBL] [Abstract][Full Text] [Related]  

  • 8. M-CSF Receptor Antagonists Inhibit the Initiation and Progression of Hepatocellular Carcinoma in Mice.
    Akazawa Y; Kono H; Hara M; Furuya S; Nakata Y; Wakana H; Fukushima H; Sun C; Fujii H; Ichikawa D
    Anticancer Res; 2019 Sep; 39(9):4787-4794. PubMed ID: 31519580
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selective M2 Macrophage Depletion Leads to Prolonged Inflammation in Surgical Wounds.
    Klinkert K; Whelan D; Clover AJP; Leblond AL; Kumar AHS; Caplice NM
    Eur Surg Res; 2017; 58(3-4):109-120. PubMed ID: 28056458
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species.
    Soto-Diaz K; Vailati-Riboni M; Louie AY; McKim DB; Gaskins HR; Johnson RW; Steelman AJ
    Front Immunol; 2021; 12():734349. PubMed ID: 34899694
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.
    Stafford JH; Hirai T; Deng L; Chernikova SB; Urata K; West BL; Brown JM
    Neuro Oncol; 2016 Jun; 18(6):797-806. PubMed ID: 26538619
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
    Ryder M; Gild M; Hohl TM; Pamer E; Knauf J; Ghossein R; Joyce JA; Fagin JA
    PLoS One; 2013; 8(1):e54302. PubMed ID: 23372702
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.
    Priceman SJ; Sung JL; Shaposhnik Z; Burton JB; Torres-Collado AX; Moughon DL; Johnson M; Lusis AJ; Cohen DA; Iruela-Arispe ML; Wu L
    Blood; 2010 Feb; 115(7):1461-71. PubMed ID: 20008303
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-alpha production.
    Nishiki S; Hato F; Kamata N; Sakamoto E; Hasegawa T; Kimura-Eto A; Hino M; Kitagawa S
    Am J Physiol Cell Physiol; 2004 Jun; 286(6):C1302-11. PubMed ID: 14736711
    [TBL] [Abstract][Full Text] [Related]  

  • 15. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia.
    Manthey CL; Johnson DL; Illig CR; Tuman RW; Zhou Z; Baker JF; Chaikin MA; Donatelli RR; Franks CF; Zeng L; Crysler C; Chen Y; Yurkow EJ; Boczon L; Meegalla SK; Wilson KJ; Wall MJ; Chen J; Ballentine SK; Ott H; Baumann C; Lawrence D; Tomczuk BE; Molloy CJ
    Mol Cancer Ther; 2009 Nov; 8(11):3151-61. PubMed ID: 19887542
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor.
    Swierczak A; Cook AD; Lenzo JC; Restall CM; Doherty JP; Anderson RL; Hamilton JA
    Cancer Immunol Res; 2014 Aug; 2(8):765-76. PubMed ID: 25005824
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.
    Eda H; Zhang J; Keith RH; Michener M; Beidler DR; Monahan JB
    Cytokine; 2010 Dec; 52(3):215-20. PubMed ID: 20829061
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The related adhesion focal tyrosine kinase (RAFTK) is tyrosine phosphorylated and participates in colony-stimulating factor-1/macrophage colony-stimulating factor signaling in monocyte-macrophages.
    Hatch WC; Ganju RK; Hiregowdara D; Avraham S; Groopman JE
    Blood; 1998 May; 91(10):3967-73. PubMed ID: 9573036
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence for cFMS signaling in HIV production by brain macrophages and microglia.
    Gerngross L; Fischer T
    J Neurovirol; 2015 Jun; 21(3):249-56. PubMed ID: 25060299
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
    Ohno H; Kubo K; Murooka H; Kobayashi Y; Nishitoba T; Shibuya M; Yoneda T; Isoe T
    Mol Cancer Ther; 2006 Nov; 5(11):2634-43. PubMed ID: 17121910
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.