BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 16250635)

  • 1. First-in-class pan caspase inhibitor developed for the treatment of liver disease.
    Linton SD; Aja T; Armstrong RA; Bai X; Chen LS; Chen N; Ching B; Contreras P; Diaz JL; Fisher CD; Fritz LC; Gladstone P; Groessl T; Gu X; Herrmann J; Hirakawa BP; Hoglen NC; Jahangiri KG; Kalish VJ; Karanewsky DS; Kodandapani L; Krebs J; McQuiston J; Meduna SP; Nalley K; Robinson ED; Sayers RO; Sebring K; Spada AP; Ternansky RJ; Tomaselli KJ; Ullman BR; Valentino KL; Weeks S; Winn D; Wu JC; Yeo P; Zhang CZ
    J Med Chem; 2005 Nov; 48(22):6779-82. PubMed ID: 16250635
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease.
    Ueno H; Kawai M; Shimokawa H; Hirota M; Ohmi M; Sudo R; Ohta A; Arano Y; Hattori K; Ohmi T; Kato N; Kojima M; Ueno Y; Yamamoto M; Moriguchi Y; Eda H; Masubuchi K
    Bioorg Med Chem Lett; 2009 Jan; 19(1):199-202. PubMed ID: 19013793
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor.
    Hoglen NC; Chen LS; Fisher CD; Hirakawa BP; Groessl T; Contreras PC
    J Pharmacol Exp Ther; 2004 May; 309(2):634-40. PubMed ID: 14742742
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Clinical trial: the efficacy and safety of oral PF-03491390, a pancaspase inhibitor - a randomized placebo-controlled study in patients with chronic hepatitis C.
    Shiffman ML; Pockros P; McHutchison JG; Schiff ER; Morris M; Burgess G
    Aliment Pharmacol Ther; 2010 May; 31(9):969-78. PubMed ID: 20163376
    [TBL] [Abstract][Full Text] [Related]  

  • 5. IDN-6556 Idun Pharmaceuticals Inc.
    Poordad FF
    Curr Opin Investig Drugs; 2004 Nov; 5(11):1198-204. PubMed ID: 15573871
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia.
    Hoglen NC; Anselmo DM; Katori M; Kaldas M; Shen XD; Valentino KL; Lassman C; Busuttil RW; Kupiec-Weglinski JW; Farmer DG
    Liver Transpl; 2007 Mar; 13(3):361-6. PubMed ID: 17318854
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C.
    Pockros PJ; Schiff ER; Shiffman ML; McHutchison JG; Gish RG; Afdhal NH; Makhviladze M; Huyghe M; Hecht D; Oltersdorf T; Shapiro DA
    Hepatology; 2007 Aug; 46(2):324-9. PubMed ID: 17654603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential caspase-9-dependent signaling pathway between tumor necrosis factor receptor- and Fas-mediated hepatocyte apoptosis in mice.
    Imao M; Nagaki M; Imose M; Moriwaki H
    Liver Int; 2006 Feb; 26(1):137-46. PubMed ID: 16420519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
    Linton SD; Aja T; Allegrini PR; Deckwerth TL; Diaz JL; Hengerer B; Herrmann J; Jahangiri KG; Kallen J; Karanewsky DS; Meduna SP; Nalley K; Robinson ED; Roggo S; Rovelli G; Sauter A; Sayers RO; Schmitz A; Smidt R; Ternansky RJ; Tomaselli KJ; Ullman BR; Wiessner C; Wu JC
    Bioorg Med Chem Lett; 2004 May; 14(10):2685-91. PubMed ID: 15109679
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs.
    Zhan XA; Wang M; Xu ZR; Li WF; Li JX
    Arch Toxicol; 2006 Feb; 80(2):74-80. PubMed ID: 16136339
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases.
    Li Z; Mizuno S; Nakamura T
    Am J Physiol Gastrointest Liver Physiol; 2007 Feb; 292(2):G639-46. PubMed ID: 17068118
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels.
    Katunuma N; Ohashi A; Sano E; Ishimaru N; Hayashi Y; Murata E
    FEBS Lett; 2006 Feb; 580(3):741-6. PubMed ID: 16413020
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Apoptosis markers in liver biopsy of nonalcoholic steatohepatitis in pediatric patients.
    Valva P; De Matteo E; Galoppo M; Pedreira A; Giacove G; Lezama C; Marco I; Galoppo MC; Preciado MV
    Hum Pathol; 2008 Dec; 39(12):1816-22. PubMed ID: 18715620
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ATP-depleting carbohydrates prevent tumor necrosis factor receptor 1-dependent apoptotic and necrotic liver injury in mice.
    Latta M; Künstle G; Lucas R; Hentze H; Wendel A
    J Pharmacol Exp Ther; 2007 Jun; 321(3):875-83. PubMed ID: 17369282
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency.
    Rudnick DA; Shikapwashya O; Blomenkamp K; Teckman JH
    Hepatology; 2006 Oct; 44(4):976-82. PubMed ID: 17006946
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress.
    Payabvash S; Kiumehr S; Nezami BG; Zandieh A; Anvari P; Tavangar SM; Dehpour AR
    Liver Int; 2007 May; 27(4):538-47. PubMed ID: 17403194
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Improvement of the survival rate after rat massive hepatectomy due to the reduction of apoptosis by caspase inhibitor.
    Yoshida N; Iwata H; Yamada T; Sekino T; Matsuo H; Shirahashi K; Miyahara T; Kiyama S; Takemura H
    J Gastroenterol Hepatol; 2007 Nov; 22(11):2015-21. PubMed ID: 17559362
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sub-lethal concentration of arsenic interferes with the proliferation of hepatocytes and induces in vivo apoptosis in Clarias batrachus L.
    Datta S; Saha DR; Ghosh D; Majumdar T; Bhattacharya S; Mazumder S
    Comp Biochem Physiol C Toxicol Pharmacol; 2007 Apr; 145(3):339-49. PubMed ID: 17336163
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells.
    Sylvester PW; Shah S
    Asia Pac J Clin Nutr; 2005; 14(4):366-73. PubMed ID: 16326643
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats.
    Jiang H; Meng F; Li W; Tong L; Qiao H; Sun X
    Surgery; 2007 Jan; 141(1):32-40. PubMed ID: 17188165
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.