351 related articles for article (PubMed ID: 16250669)
1. Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Barreca ML; Ferro S; Rao A; De Luca L; Zappalà M; Monforte AM; Debyser Z; Witvrouw M; Chimirri A
J Med Chem; 2005 Nov; 48(22):7084-8. PubMed ID: 16250669
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Vandurm P; Guiguen A; Cauvin C; Georges B; Le Van K; Michaux C; Cardona C; Mbemba G; Mouscadet JF; Hevesi L; Van Lint C; Wouters J
Eur J Med Chem; 2011 May; 46(5):1749-56. PubMed ID: 21385662
[TBL] [Abstract][Full Text] [Related]
3. [Advances in the study of HIV-1 integrase inhibitors of alpha, gamma-diketo compounds].
Yu SH; Tan YM; Zhao GS
Yao Xue Xue Bao; 2010 Feb; 45(2):215-23. PubMed ID: 21351431
[TBL] [Abstract][Full Text] [Related]
4. Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
Walker MA; Johnson T; Ma Z; Banville J; Remillard R; Kim O; Zhang Y; Staab A; Wong H; Torri A; Samanta H; Lin Z; Deminie C; Terry B; Krystal M; Meanwell N
Bioorg Med Chem Lett; 2006 Jun; 16(11):2920-4. PubMed ID: 16546383
[TBL] [Abstract][Full Text] [Related]
5. Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.
Dayam R; Sanchez T; Neamati N
J Med Chem; 2005 Dec; 48(25):8009-15. PubMed ID: 16335925
[TBL] [Abstract][Full Text] [Related]
6. A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores.
Kawasuji T; Yoshinaga T; Sato A; Yodo M; Fujiwara T; Kiyama R
Bioorg Med Chem; 2006 Dec; 14(24):8430-45. PubMed ID: 17010623
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors.
Hu L; Zhang S; He X; Luo Z; Wang X; Liu W; Qin X
Bioorg Med Chem; 2012 Jan; 20(1):177-82. PubMed ID: 22154762
[TBL] [Abstract][Full Text] [Related]
8. New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Ferro S; Barreca ML; De Luca L; Rao A; Monforte AM; Debyser Z; Witvrouw M; Chimirri A
Arch Pharm (Weinheim); 2007 Jun; 340(6):292-8. PubMed ID: 17562561
[TBL] [Abstract][Full Text] [Related]
9. Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors.
Dayam R; Sanchez T; Clement O; Shoemaker R; Sei S; Neamati N
J Med Chem; 2005 Jan; 48(1):111-20. PubMed ID: 15634005
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Sechi M; Derudas M; Dallocchio R; Dessì A; Bacchi A; Sannia L; Carta F; Palomba M; Ragab O; Chan C; Shoemaker R; Sei S; Dayam R; Neamati N
J Med Chem; 2004 Oct; 47(21):5298-310. PubMed ID: 15456274
[TBL] [Abstract][Full Text] [Related]
11. Benzyl amide-ketoacid inhibitors of HIV-integrase.
Walker MA; Johnson T; Naidu BN; Banville J; Remillard R; Plamondon S; Martel A; Li C; Torri A; Samanta H; Lin Z; Dicker I; Krystal M; Meanwell NA
Bioorg Med Chem Lett; 2007 Sep; 17(17):4886-90. PubMed ID: 17604626
[TBL] [Abstract][Full Text] [Related]
12. Conformationally restrained carbazolone-containing alpha,gamma-diketo acids as inhibitors of HIV integrase.
Li X; Vince R
Bioorg Med Chem; 2006 May; 14(9):2942-55. PubMed ID: 16386908
[TBL] [Abstract][Full Text] [Related]
13. Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
Li H; Wang C; Sanchez T; Tan Y; Jiang C; Neamati N; Zhao G
Bioorg Med Chem; 2009 Apr; 17(7):2913-9. PubMed ID: 19269185
[TBL] [Abstract][Full Text] [Related]
14. A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
Kawasuji T; Fuji M; Yoshinaga T; Sato A; Fujiwara T; Kiyama R
Bioorg Med Chem; 2006 Dec; 14(24):8420-9. PubMed ID: 17005407
[TBL] [Abstract][Full Text] [Related]
15. Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.
Czyz A; Stillmock KA; Hazuda DJ; Reznikoff WS
Biochemistry; 2007 Sep; 46(38):10776-89. PubMed ID: 17725323
[TBL] [Abstract][Full Text] [Related]
16. Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.
Deng J; Lee KW; Sanchez T; Cui M; Neamati N; Briggs JM
J Med Chem; 2005 Mar; 48(5):1496-505. PubMed ID: 15743192
[TBL] [Abstract][Full Text] [Related]
17. Pharmacophore modelling and atom-based 3D-QSAR studies on N-methyl pyrimidones as HIV-1 integrase inhibitors.
Reddy KK; Singh SK; Dessalew N; Tripathi SK; Selvaraj C
J Enzyme Inhib Med Chem; 2012 Jun; 27(3):339-47. PubMed ID: 21699459
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, and biological evaluation of novel hybrid dicaffeoyltartaric/diketo acid and tetrazole-substituted L-chicoric acid analogue inhibitors of human immunodeficiency virus type 1 integrase.
Crosby DC; Lei X; Gibbs CG; McDougall BR; Robinson WE; Reinecke MG
J Med Chem; 2010 Nov; 53(22):8161-75. PubMed ID: 20977258
[TBL] [Abstract][Full Text] [Related]
19. Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
Verschueren WG; Dierynck I; Amssoms KI; Hu L; Boonants PM; Pille GM; Daeyaert FF; Hertogs K; Surleraux DL; Wigerinck PB
J Med Chem; 2005 Mar; 48(6):1930-40. PubMed ID: 15771437
[TBL] [Abstract][Full Text] [Related]
20. Pharmacophore and structure-activity relationships of integrase inhibition within a dual inhibitor scaffold of HIV reverse transcriptase and integrase.
Wang Z; Tang J; Salomon CE; Dreis CD; Vince R
Bioorg Med Chem; 2010 Jun; 18(12):4202-11. PubMed ID: 20576573
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
