BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

104 related articles for article (PubMed ID: 16250842)

  • 21. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Progress in the discovery of BACE inhibitors.
    Thompson LA; Bronson JJ; Zusi FC
    Curr Pharm Des; 2005; 11(26):3383-404. PubMed ID: 16250843
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
    Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
    Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge.
    Citron M
    Trends Pharmacol Sci; 2004 Feb; 25(2):92-7. PubMed ID: 15102495
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization.
    Schenk D; Games D; Seubert P
    J Mol Neurosci; 2001 Oct; 17(2):259-67. PubMed ID: 11816797
    [TBL] [Abstract][Full Text] [Related]  

  • 26. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
    Shearman MS; Beher D; Clarke EE; Lewis HD; Harrison T; Hunt P; Nadin A; Smith AL; Stevenson G; Castro JL
    Biochemistry; 2000 Aug; 39(30):8698-704. PubMed ID: 10913280
    [TBL] [Abstract][Full Text] [Related]  

  • 27. The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors.
    Aisen PS
    CNS Drugs; 2005; 19(12):989-96. PubMed ID: 16332141
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.
    Klaver DW; Wilce MC; Cui H; Hung AC; Gasperini R; Foa L; Small DH
    Biol Chem; 2010 Aug; 391(8):849-59. PubMed ID: 20731541
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
    Moore CL; Leatherwood DD; Diehl TS; Selkoe DJ; Wolfe MS
    J Med Chem; 2000 Sep; 43(18):3434-42. PubMed ID: 10978191
    [TBL] [Abstract][Full Text] [Related]  

  • 30. BACE1 in Alzheimer's disease.
    Sathya M; Premkumar P; Karthick C; Moorthi P; Jayachandran KS; Anusuyadevi M
    Clin Chim Acta; 2012 Dec; 414():171-8. PubMed ID: 22926063
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.
    D'Onofrio G; Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Paroni G; Cascavilla L; Seripa D; Pilotto A
    Expert Opin Drug Discov; 2012 Jan; 7(1):19-37. PubMed ID: 22468891
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Gamma-secretase: a catalyst of Alzheimer disease and signal transduction.
    Li YM
    Mol Interv; 2001 Oct; 1(4):198-207. PubMed ID: 14993342
    [TBL] [Abstract][Full Text] [Related]  

  • 33. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
    Roberds SL; Anderson J; Basi G; Bienkowski MJ; Branstetter DG; Chen KS; Freedman SB; Frigon NL; Games D; Hu K; Johnson-Wood K; Kappenman KE; Kawabe TT; Kola I; Kuehn R; Lee M; Liu W; Motter R; Nichols NF; Power M; Robertson DW; Schenk D; Schoor M; Shopp GM; Shuck ME; Sinha S; Svensson KA; Tatsuno G; Tintrup H; Wijsman J; Wright S; McConlogue L
    Hum Mol Genet; 2001 Jun; 10(12):1317-24. PubMed ID: 11406613
    [TBL] [Abstract][Full Text] [Related]  

  • 34. gamma-Secretase inhibitors as molecular probes of presenilin function.
    Wolfe MS
    J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
    Hook VY; Reisine TD
    J Neurosci Res; 2003 Nov; 74(3):393-405. PubMed ID: 14598316
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
    Beher D; Wrigley JD; Owens AP; Shearman MS
    J Neurochem; 2002 Aug; 82(3):563-75. PubMed ID: 12153480
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
    Hook VY; Toneff T; Aaron W; Yasothornsrikul S; Bundey R; Reisine T
    J Neurochem; 2002 Apr; 81(2):237-56. PubMed ID: 12064471
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
    Campbell WA; Reed ML; Strahle J; Wolfe MS; Xia W
    J Neurochem; 2003 Jun; 85(6):1563-74. PubMed ID: 12787075
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase.
    Middendorp O; Lüthi U; Hausch F; Barberis A
    Biol Chem; 2004 Jun; 385(6):481-5. PubMed ID: 15255179
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.