476 related articles for article (PubMed ID: 16251255)
41. Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways.
Han X; Szostek B; Yang CH; Cheatham SF; Mingoia RT; Nabb DL; Gannon SA; Himmelstein MW; Jepson GW
Drug Metab Dispos; 2011 Jul; 39(7):1288-93. PubMed ID: 21493824
[TBL] [Abstract][Full Text] [Related]
42. Identification of BVT.2938 metabolites by LC/MS and LC/MS/MS after in vitro incubations with liver microsomes and hepatocytes.
Edlund PO; Baranczewski P
J Pharm Biomed Anal; 2004 Mar; 34(5):1079-90. PubMed ID: 15019042
[TBL] [Abstract][Full Text] [Related]
43. Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys.
Dean B; Chang S; Doss GA; King C; Thomas PE
Arch Biochem Biophys; 2004 Sep; 429(2):244-51. PubMed ID: 15313229
[TBL] [Abstract][Full Text] [Related]
44. Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.
Kochansky CJ; Xia YQ; Wang S; Cato B; Creighton M; Vincent SH; Franklin RB; Reed JR
Drug Metab Dispos; 2005 Dec; 33(12):1894-904. PubMed ID: 16183782
[TBL] [Abstract][Full Text] [Related]
45. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
Singh R; Silva Elipe MV; Pearson PG; Arison BH; Wong BK; White R; Yu X; Burgey CS; Lin JH; Baillie TA
Chem Res Toxicol; 2003 Feb; 16(2):198-207. PubMed ID: 12588191
[TBL] [Abstract][Full Text] [Related]
46. Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
Yu J; Folmer JJ; Hoesch V; Doherty J; Campbell JB; Burdette D
Drug Metab Dispos; 2011 Feb; 39(2):302-11. PubMed ID: 21045198
[TBL] [Abstract][Full Text] [Related]
47. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
Tang W; Abbott FS
Chem Res Toxicol; 1996 Mar; 9(2):517-26. PubMed ID: 8839057
[TBL] [Abstract][Full Text] [Related]
48. N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.
Yin W; Doss GA; Stearns RA; Kumar S
Drug Metab Dispos; 2004 Jan; 32(1):43-8. PubMed ID: 14709619
[TBL] [Abstract][Full Text] [Related]
49. Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes.
Chen W; Caceres-Cortes J; Zhang H; Zhang D; Humphreys WG; Gan J
Chem Res Toxicol; 2011 May; 24(5):663-9. PubMed ID: 21417487
[TBL] [Abstract][Full Text] [Related]
50. Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine.
Yu J; Mathisen DE; Burdette D; Brown DG; Becker C; Aharony D
Drug Metab Dispos; 2010 Jan; 38(1):46-60. PubMed ID: 19812352
[TBL] [Abstract][Full Text] [Related]
51. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition.
Yan Z; Caldwell GW; Maher N
Anal Chem; 2008 Aug; 80(16):6410-22. PubMed ID: 18642850
[TBL] [Abstract][Full Text] [Related]
52. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
[TBL] [Abstract][Full Text] [Related]
53. Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes.
Ma S; Subramanian R; Xu Y; Schrag M; Shou M
Drug Metab Dispos; 2008 Dec; 36(12):2414-8. PubMed ID: 18799804
[TBL] [Abstract][Full Text] [Related]
54. Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
Chen H; Grover S; Yu L; Walker G; Mutlib A
Chem Res Toxicol; 2010 Jan; 23(1):159-70. PubMed ID: 19961160
[TBL] [Abstract][Full Text] [Related]
55. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
Alvarez-Diez TM; Zheng J
Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
[TBL] [Abstract][Full Text] [Related]
56. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
Damsten MC; de Vlieger JS; Niessen WM; Irth H; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2008 Nov; 21(11):2181-7. PubMed ID: 18816075
[TBL] [Abstract][Full Text] [Related]
57. Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Samuel K; Yin W; Stearns RA; Tang YS; Chaudhary AG; Jewell JP; Lanza T; Lin LS; Hagmann WK; Evans DC; Kumar S
J Mass Spectrom; 2003 Feb; 38(2):211-21. PubMed ID: 12577288
[TBL] [Abstract][Full Text] [Related]
58. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Lim HK; Chen J; Cook K; Sensenhauser C; Silva J; Evans DC
Rapid Commun Mass Spectrom; 2008 Apr; 22(8):1295-311. PubMed ID: 18383206
[TBL] [Abstract][Full Text] [Related]
59. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.
Smith KS; Smith PL; Heady TN; Trugman JM; Harman WD; Macdonald TL
Chem Res Toxicol; 2003 Feb; 16(2):123-8. PubMed ID: 12588182
[TBL] [Abstract][Full Text] [Related]
60. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
Lang D; Freudenberger C; Weinz C
Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
