These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

357 related articles for article (PubMed ID: 16274252)

  • 1. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
    Madiraju C; Edler MC; Hamel E; Raccor BS; Balachandran R; Zhu G; Giuliano KA; Vogt A; Shin Y; Fournier JH; Fukui Y; Brückner AM; Curran DP; Day BW
    Biochemistry; 2005 Nov; 44(45):15053-63. PubMed ID: 16274252
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
    Kowalski RJ; Giannakakou P; Gunasekera SP; Longley RE; Day BW; Hamel E
    Mol Pharmacol; 1997 Oct; 52(4):613-22. PubMed ID: 9380024
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
    ter Haar E; Kowalski RJ; Hamel E; Lin CM; Longley RE; Gunasekera SP; Rosenkranz HS; Day BW
    Biochemistry; 1996 Jan; 35(1):243-50. PubMed ID: 8555181
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.
    Xia S; Kenesky CS; Rucker PV; Smith AB; Orr GA; Horwitz SB
    Biochemistry; 2006 Oct; 45(39):11762-75. PubMed ID: 17002277
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
    Raccor BS; Vogt A; Sikorski RP; Madiraju C; Balachandran R; Montgomery K; Shin Y; Fukui Y; Jung WH; Curran DP; Day BW
    Mol Pharmacol; 2008 Mar; 73(3):718-26. PubMed ID: 18073274
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
    Paterson I; Gardner NM; Guzmán E; Wright AE
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6268-72. PubMed ID: 18951787
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide.
    Gertsch J; Meier S; Müller M; Altmann KH
    Chembiochem; 2009 Jan; 10(1):166-75. PubMed ID: 19058273
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
    Paterson I; Naylor GJ; Wright AE
    Chem Commun (Camb); 2008 Oct; (38):4628-30. PubMed ID: 18815706
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.
    Honore S; Kamath K; Braguer D; Horwitz SB; Wilson L; Briand C; Jordan MA
    Cancer Res; 2004 Jul; 64(14):4957-64. PubMed ID: 15256469
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.
    Edler MC; Buey RM; Gussio R; Marcus AI; Vanderwal CD; Sorensen EJ; Díaz JF; Giannakakou P; Hamel E
    Biochemistry; 2005 Aug; 44(34):11525-38. PubMed ID: 16114889
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.
    Canales A; Rodríguez-Salarichs J; Trigili C; Nieto L; Coderch C; Andreu JM; Paterson I; Jiménez-Barbero J; Díaz JF
    ACS Chem Biol; 2011 Aug; 6(8):789-99. PubMed ID: 21539341
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel.
    Dabydeen DA; Florence GJ; Paterson I; Hamel E
    Cancer Chemother Pharmacol; 2004 May; 53(5):397-403. PubMed ID: 15060743
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.
    Choy N; Shin Y; Nguyen PQ; Curran DP; Balachandran R; Madiraju C; Day BW
    J Med Chem; 2003 Jul; 46(14):2846-64. PubMed ID: 12825928
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
    Paterson I; Naylor GJ; Fujita T; Guzmán E; Wright AE
    Chem Commun (Camb); 2010 Jan; 46(2):261-3. PubMed ID: 20024345
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
    Florence GJ; Gardner NM; Paterson I
    Nat Prod Rep; 2008 Apr; 25(2):342-75. PubMed ID: 18389141
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.
    Buey RM; Barasoain I; Jackson E; Meyer A; Giannakakou P; Paterson I; Mooberry S; Andreu JM; Díaz JF
    Chem Biol; 2005 Dec; 12(12):1269-79. PubMed ID: 16356844
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.
    Vollmer LL; Jiménez M; Camarco DP; Zhu W; Daghestani HN; Balachandran R; Reese CE; Lazo JS; Hukriede NA; Curran DP; Day BW; Vogt A
    Mol Cancer Ther; 2011 Jun; 10(6):994-1006. PubMed ID: 21490306
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.
    Paterson I; Naylor GJ; Gardner NM; Guzmán E; Wright AE
    Chem Asian J; 2011 Feb; 6(2):459-73. PubMed ID: 21254424
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
    Paterson I; Gardner NM; Poullennec KG; Wright AE
    J Nat Prod; 2008 Mar; 71(3):364-9. PubMed ID: 18081257
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.
    Gapud EJ; Bai R; Ghosh AK; Hamel E
    Mol Pharmacol; 2004 Jul; 66(1):113-21. PubMed ID: 15213302
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.