These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 16275079)

  • 21. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Overexpression of calsenilin enhances gamma-secretase activity.
    Jo DG; Jang J; Kim BJ; Lundkvist J; Jung YK
    Neurosci Lett; 2005 Apr; 378(1):59-64. PubMed ID: 15763173
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
    Lanz TA; Hosley JD; Adams WJ; Merchant KM
    J Pharmacol Exp Ther; 2004 Apr; 309(1):49-55. PubMed ID: 14718585
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors.
    Wood S; Wen PH; Zhang J; Zhu L; Luo Y; Babu-Khan S; Chen K; Pham R; Esmay J; Dineen TA; Kaller MR; Weiss MM; Hitchcock SA; Citron M; Zhong W; Hickman D; Williamson T
    J Pharmacol Exp Ther; 2012 Nov; 343(2):460-7. PubMed ID: 22911925
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors.
    Chun J; Yin YI; Yang G; Tarassishin L; Li YM
    J Org Chem; 2004 Oct; 69(21):7344-7. PubMed ID: 15471490
    [TBL] [Abstract][Full Text] [Related]  

  • 28. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 29. In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.
    Best JD; Jay MT; Otu F; Churcher I; Reilly M; Morentin-Gutierrez P; Pattison C; Harrison T; Shearman MS; Atack JR
    J Pharmacol Exp Ther; 2006 May; 317(2):786-90. PubMed ID: 16443723
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Hydroxytriamides as potent gamma-secretase inhibitors.
    Prasad CV; Wallace OB; Noonan JW; Sloan CP; Lau W; Vig S; Parker MF; Smith DW; Hansel SB; Polson CT; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2004 Apr; 14(8):1917-21. PubMed ID: 15050627
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.
    Laras Y; Quéléver G; Garino C; Pietrancosta N; Sheha M; Bihel F; Wolfe MS; Kraus JL
    Org Biomol Chem; 2005 Feb; 3(4):612-8. PubMed ID: 15703796
    [TBL] [Abstract][Full Text] [Related]  

  • 32. A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
    Lewis SJ; Smith AL; Neduvelil JG; Stevenson GI; Lindon MJ; Jones AB; Shearman MS; Beher D; Clarke E; Best JD; Peachey JE; Harrison T; Castro JL
    Bioorg Med Chem Lett; 2005 Jan; 15(2):373-8. PubMed ID: 15603957
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
    Abbenante G; Kovacs DM; Leung DL; Craik DJ; Tanzi RE; Fairlie DP
    Biochem Biophys Res Commun; 2000 Feb; 268(1):133-5. PubMed ID: 10652226
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
    Stanton MG; Stauffer SR; Gregro AR; Steinbeiser M; Nantermet P; Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Ellis J; Lai MT; Espeseth AS; Shi XP; Jin L; Colussi D; Pietrak B; Huang Q; Xu M; Simon AJ; Graham SL; Vacca JP; Selnick H
    J Med Chem; 2007 Jul; 50(15):3431-3. PubMed ID: 17583334
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.
    Rueeger H; Lueoend R; Rogel O; Rondeau JM; Möbitz H; Machauer R; Jacobson L; Staufenbiel M; Desrayaud S; Neumann U
    J Med Chem; 2012 Apr; 55(7):3364-86. PubMed ID: 22380629
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.
    Hyde LA; McHugh NA; Chen J; Zhang Q; Manfra D; Nomeir AA; Josien H; Bara T; Clader JW; Zhang L; Parker EM; Higgins GA
    J Pharmacol Exp Ther; 2006 Dec; 319(3):1133-43. PubMed ID: 16946102
    [TBL] [Abstract][Full Text] [Related]  

  • 38. QSAR studies--potent benzodiazepine gamma-secretase inhibitors.
    Ravi Keerti A; Ashok Kumar B; Parthasarathy T; Uma V
    Bioorg Med Chem; 2005 Mar; 13(5):1873-8. PubMed ID: 15698805
    [TBL] [Abstract][Full Text] [Related]  

  • 39. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.
    Yoon SY; Choi JE; Yoon JH; Huh JW; Kim DH
    Neurobiol Dis; 2006 May; 22(2):435-44. PubMed ID: 16480887
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
    Kimura T; Hamada Y; Stochaj M; Ikari H; Nagamine A; Abdel-Rahman H; Igawa N; Hidaka K; Nguyen JT; Saito K; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2006 May; 16(9):2380-6. PubMed ID: 16481167
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.