BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 16275080)

  • 1. Substituted indanylacetic acids as PPAR-alpha-gamma activators.
    Lowe DB; Bifulco N; Bullock WH; Claus T; Coish P; Dai M; Dela Cruz FE; Dickson D; Fan D; Hoover-Litty H; Li T; Ma X; Mannelly G; Monahan MK; Muegge I; O'Connor S; Rodriguez M; Shelekhin T; Stolle A; Sweet L; Wang M; Wang Y; Zhang C; Zhang HJ; Zhang M; Zhao K; Zhao Q; Zhu J; Zhu L; Tsutsumi M
    Bioorg Med Chem Lett; 2006 Jan; 16(2):297-301. PubMed ID: 16275080
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists.
    Cantin LD; Liang S; Ogutu H; Iwuagwu CI; Boakye K; Bullock WH; Burns M; Clark R; Claus T; delaCruz FE; Daly M; Ehrgott FJ; Johnson JS; Keiper C; Livingston JN; Schoenleber RW; Shapiro J; Town C; Yang L; Tsutsumi M; Ma X
    Bioorg Med Chem Lett; 2007 Feb; 17(4):1056-61. PubMed ID: 17157013
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.
    Rudolph J; Chen L; Majumdar D; Bullock WH; Burns M; Claus T; Dela Cruz FE; Daly M; Ehrgott FJ; Johnson JS; Livingston JN; Schoenleber RW; Shapiro J; Yang L; Tsutsumi M; Ma X
    J Med Chem; 2007 Mar; 50(5):984-1000. PubMed ID: 17274610
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and evaluation of carbazole derivatives as PPAR alpha/gamma dual agonists and antioxidants.
    Kumar R; Ramachandran U; Srinivasan K; Ramarao P; Raichur S; Chakrabarti R
    Bioorg Med Chem; 2005 Jul; 13(13):4279-90. PubMed ID: 15869880
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
    Zhang H; Ryono DE; Devasthale P; Wang W; O'Malley K; Farrelly D; Gu L; Harrity T; Cap M; Chu C; Locke K; Zhang L; Lippy J; Kunselman L; Morgan N; Flynn N; Moore L; Hosagrahara V; Zhang L; Kadiyala P; Xu C; Doweyko AM; Bell A; Chang C; Muckelbauer J; Zahler R; Hariharan N; Cheng PT
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1451-6. PubMed ID: 19201606
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Pingali H; Jain M; Shah S; Makadia P; Zaware P; Goel A; Patel M; Giri S; Patel H; Patel P
    Bioorg Med Chem; 2008 Aug; 16(15):7117-27. PubMed ID: 18625559
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
    Devasthale PV; Chen S; Jeon Y; Qu F; Shao C; Wang W; Zhang H; Cap M; Farrelly D; Golla R; Grover G; Harrity T; Ma Z; Moore L; Ren J; Seethala R; Cheng L; Sleph P; Sun W; Tieman A; Wetterau JR; Doweyko A; Chandrasena G; Chang SY; Humphreys WG; Sasseville VG; Biller SA; Ryono DE; Selan F; Hariharan N; Cheng PT
    J Med Chem; 2005 Mar; 48(6):2248-50. PubMed ID: 15771468
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG; Kim NJ; Koo BW; Lee KO; Moon SH; Shin DH; Jung JW; Paek SM; Chang DJ; Li F; Kang HJ; Le TV; Chae YN; Shin CY; Kim MK; Lim JI; Ryu JS; Park HJ
    J Med Chem; 2008 Oct; 51(20):6318-33. PubMed ID: 18826205
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.
    Yu J; Tang L; Yang Y; Ji R
    Eur J Med Chem; 2008 Nov; 43(11):2428-35. PubMed ID: 18329751
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS; Almaden JV; Barnum SJ; Carlson TJ; Do QQ; Fraser JD; Hess M; Kim YH; Ogilvie KM; Sun S
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6116-9. PubMed ID: 16979341
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS; Bailey S; Almaden JV; Barnum SJ; Carlson TJ; Christie LC; Do QQ; Fraser JD; Hess M; Kellum J; Kim YH; McClellan GA; Ogilvie KM; Simmons BH; Skalitzky D; Sun S; Wilhite D; Zehnder LR
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6120-3. PubMed ID: 16973358
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of a new class of benzoylpyrrole-based PPARα/γ activators.
    Ushiroda K; Maruta K; Kitoh M; Iwai K; Nagamine J; Tsuchida A; Taiji M; Nagata R
    Bioorg Med Chem Lett; 2011 Jan; 21(1):220-4. PubMed ID: 21130649
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
    Devasthale PV; Chen S; Jeon Y; Qu F; Ryono DE; Wang W; Zhang H; Cheng L; Farrelly D; Golla R; Grover G; Ma Z; Moore L; Seethala R; Sun W; Doweyko AM; Chandrasena G; Sleph P; Hariharan N; Cheng PT
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2312-6. PubMed ID: 17292606
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.
    Oon Han H; Kim SH; Kim KH; Hur GC; Joo Yim H; Chung HK; Ho Woo S; Dong Koo K; Lee CS; Sung Koh J; Kim GT
    Bioorg Med Chem Lett; 2007 Feb; 17(4):937-41. PubMed ID: 17157019
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
    Raval P; Jain M; Goswami A; Basu S; Gite A; Godha A; Pingali H; Raval S; Giri S; Suthar D; Shah M; Patel P
    Bioorg Med Chem Lett; 2011 May; 21(10):3103-9. PubMed ID: 21450468
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
    Kim MK; Chae YN; Son MH; Kim SH; Kim JK; Moon HS; Park CS; Bae MH; Kim E; Han T; Choi HH; Shin YA; Ahn BN; Lee CH; Lim JI; Shin CY
    Eur J Pharmacol; 2008 Oct; 595(1-3):119-25. PubMed ID: 18727927
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.
    Casimiro-Garcia A; Bigge CF; Davis JA; Padalino T; Pulaski J; Ohren JF; McConnell P; Kane CD; Royer LJ; Stevens KA; Auerbach B; Collard W; McGregor C; Song K
    Bioorg Med Chem; 2009 Oct; 17(20):7113-25. PubMed ID: 19783444
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice.
    Hu X; Feng Y; Shen Y; Zhao XF; Yu JH; Yang YS; Leng Y
    Acta Pharmacol Sin; 2006 Oct; 27(10):1346-52. PubMed ID: 17007742
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.
    Li Z; Liao C; Ko BC; Shan S; Tong EH; Yin Z; Pan D; Wong VK; Shi L; Ning ZQ; Hu W; Zhou J; Chung SS; Lu XP
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3507-11. PubMed ID: 15177462
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
    Zhang H; Ding CZ; Lai Z; Chen SS; Devasthale P; Herpin T; Morton G; Qu F; Ryono D; Smirk R; Wang W; Wu S; Ye XX; Li YX; Apedo A; Farrelly D; Wang T; Gu L; Morgan N; Flynn N; Chu C; Kunselman L; Lippy J; Locke K; O'Malley K; Harrity T; Cap M; Zhang L; Hosagrahara V; Kadiyala P; Xu C; Doweyko AM; Zahler R; Hariharan N; Cheng PT
    Bioorg Med Chem Lett; 2015 Mar; 25(6):1196-205. PubMed ID: 25686852
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.