These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 1627546)

  • 1. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation.
    Carreras CW; Climie SC; Santi DV
    Biochemistry; 1992 Jul; 31(26):6038-44. PubMed ID: 1627546
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis.
    Chiericatti G; Santi DV
    Biochemistry; 1998 Jun; 37(25):9038-42. PubMed ID: 9636048
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.
    Kealey JT; Eckstein J; Santi DV
    Chem Biol; 1995 Sep; 2(9):609-14. PubMed ID: 9383465
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
    Birdsall DL; Huang W; Santi DV; Stroud RM; Finer-Moore J
    Protein Eng; 1998 Mar; 11(3):171-83. PubMed ID: 9613841
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
    Perry KM; Carreras CW; Chang LC; Santi DV; Stroud RM
    Biochemistry; 1993 Jul; 32(28):7116-25. PubMed ID: 8343503
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Partial restoration of activity to Lactobacillus casei thymidylate synthase following inactivation by domain deletion.
    Schellenberger U; Balaram P; Francis VS; Shoichet BK; Santi DV
    Biochemistry; 1994 May; 33(18):5623-9. PubMed ID: 8180187
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Isolation of a covalent steady-state intermediate in glutamate 60 mutants of thymidylate synthase.
    Huang W; Santi DV
    J Biol Chem; 1994 Dec; 269(50):31327-9. PubMed ID: 7989294
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants.
    Variath P; Liu Y; Lee TT; Stroud RM; Santi DV
    Biochemistry; 2000 Mar; 39(10):2429-35. PubMed ID: 10704192
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
    Finer-Moore JS; Liu L; Birdsall DL; Brem R; Apfeld J; Santi DV; Stroud RM
    J Mol Biol; 1998 Feb; 276(1):113-29. PubMed ID: 9514716
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
    Finer-Moore JS; Fauman EB; Morse RJ; Santi DV; Stroud RM
    Protein Eng; 1996 Jan; 9(1):69-75. PubMed ID: 9053905
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase.
    Liu L; Santi DV
    Biochemistry; 1992 Jun; 31(22):5100-4. PubMed ID: 1606134
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
    Kaiyawet N; Rungrotmongkol T; Hannongbua S
    J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Complete replacement set of amino acids at the C-terminus of thymidylate synthase: quantitative structure-activity relationship of mutants of an enzyme.
    Climie SC; Carreras CW; Santi DV
    Biochemistry; 1992 Jul; 31(26):6032-8. PubMed ID: 1627545
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
    Costi PM; Liu L; Finer-Moore JS; Stroud RM; Santi DV
    Biochemistry; 1996 Apr; 35(13):3944-9. PubMed ID: 8672425
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
    Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
    Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Active site general catalysts are not necessary for some proton transfer reactions of thymidylate synthase.
    Huang W; Santi DV
    Biochemistry; 1997 Feb; 36(7):1869-73. PubMed ID: 9048572
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
    Connick TJ; Reilly RT; Dunlap RB; Ellis PD
    Biochim Biophys Acta; 1994 Sep; 1208(1):118-26. PubMed ID: 8086425
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate.
    Liu Y; Barrett JE; Schultz PG; Santi DV
    Biochemistry; 1999 Jan; 38(2):848-52. PubMed ID: 9888826
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.